Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Frederik Rostrup"'
Autor:
David E. Gloriam, Rebekka Löffler, Frederik Rostrup, Petrine Wellendorph, Bente Frølund, Christina Birkedahl Falk-Petersen, Kasper Harpsøe, Stine Buchleithner
Publikováno v:
Molecular Pharmacology. 100:46-56
Delta selective compound 2 (DS2; 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide) is one of the most widely used tools to study selective actions mediated by δ-subunit-containing GABAA receptors. DS2 was discovered over 10 years ago, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61e1339ce2ac4e170729ea407919188
https://doi.org/10.1124/molpharm.121.000266
https://doi.org/10.1124/molpharm.121.000266
Autor:
Tanja Schirmeister, David E. Gloriam, Stine Buchleithner, Christina Birkedahl Falk-Petersen, Sascha Jung, Frederik Rostrup, Petrine Wellendorph, Kasper Harpso E, Irene Conforti, Bente Fro Lund
Publikováno v:
Journal of Medicinal Chemistry. 64:4730-4743
Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02308ec1ce21233bb0652767e5b2c0c
https://doi.org/10.1021/acs.jmedchem.0c02163
https://doi.org/10.1021/acs.jmedchem.0c02163
Autor:
Francesco Bavo, Heleen de-Jong, Jonas Petersen, Christina Birkedahl Falk-Petersen, Rebekka Löffler, Emma Sparrow, Frederik Rostrup, Jannik Nicklas Eliasen, Kristine S. Wilhelmsen, Kasper Barslund, Christoffer Bundgaard, Birgitte Nielsen, Uffe Kristiansen, Petrine Wellendorph, Yury Bogdanov, Bente Frølund
The 3,9-diazaspiro[5.5]undecane-based compounds 2027 and 018 have previously been reported to be potent competitive γ-aminobutyric acid type A receptor (GABAAR) antagonists showing low cellular membrane permeability. Given the emerging peripheral ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1b8597a5aeec1385cffce2213ce18f
https://eprints.soton.ac.uk/454543/
https://eprints.soton.ac.uk/454543/
Autor:
Christina B, Falk-Petersen, Frederik, Rostrup, Rebekka, Löffler, Stine, Buchleithner, Kasper, Harpsøe, David E, Gloriam, Bente, Frølund, Petrine, Wellendorph
Publikováno v:
Molecular pharmacology. 100(1)
Delta selective compound 2 (DS2; 4-chloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c837e23849f8f58d6be669f190f31e85
https://pubmed.ncbi.nlm.nih.gov/33990405
https://pubmed.ncbi.nlm.nih.gov/33990405
Autor:
Kasper Harpsøe, Christina Birkedahl Falk-Petersen, Rebekka Löffler, David E. Gloriam, Petrine Wellendorph, Frederik Rostrup, Stine Buchleithner, Bente Frølund
Delta selective compound 2 (DS2) is one of the most widely used tools to study selective actions mediated by δ subunit-containing GABAA receptors. DS2 was discovered over 10 years ago, but despite great efforts, the precise molecular site of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acdb2ee1ddc3df8b270b203444a0df85
https://doi.org/10.1101/2021.01.21.427670
https://doi.org/10.1101/2021.01.21.427670
Autor:
David E. Gloriam, Tanja Schirmeister, Christina Birkedahl Falk-Petersen, Stine Buchleithner, Kasper Harpsøe, Frederik Rostrup, Petrine Wellendorph, Sascha Jung, Bente Frølund, Irene Conforti
A SAR study of the delta-selective positive modulators DS2 was performed to assist the quest for the binding site. The modulatory effect was measured using a fluorometric inaging plate reader (FLIPR) membrane potential (FMP) functional assay. Specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf5e25f7f3f2a9f11633076a277c398
https://doi.org/10.26434/chemrxiv.13395416.v1
https://doi.org/10.26434/chemrxiv.13395416.v1
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