Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12

Autor: Jakob V. Olsen, Frederik Diness, Milena E. Roux, Mikael Bols, Morten Meldal, Sanne Schoffelen, Frederik Præstholm Jørgensen, Daniel H. Madsen, Daniel Palmer

Publikováno v: Madsen, D, Jørgensen, F P, Palmer, D, Roux, M E, Olsen, J V, Bols, M, Schoffelen, S, Diness, F & Meldal, M 2020, ' Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12 ', ACS Combinatorial Science, vol. 22, no. 3, pp. 156-164 . https://doi.org/10.1021/acscombsci.9b00197

On the basis of computational design, a focused one-bead one-compound library has been prepared on microparticle-encoded PEGA1900 beads consisting of small tripeptides with a triazole-capped N-terminal. The library was screened towards a double point

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f706aca65a47aa4b7357a2398b15ddb
https://pubmed.ncbi.nlm.nih.gov/32027120

Synthesis of Covalently Linked Oligo(phenyleneethynylene) Wires Incorporating Dithiafulvene Units: Redox-Active 'H-Cruciforms'

Autor: Frederik Præstholm Jørgensen, Martyn Jevric, Anders B. Skov, Mogens Brøndsted Nielsen, Ole Hammerich, Cecilie Lindholm Andersen, Johannes Petersen

Publikováno v: European Journal of Organic Chemistry. 2017:1253-1261

Controlled alignment and self-assembly of molecular wires is one of the challenges in the field of molecular electronics. Here we take an approach by which two oligo(phenyleneethynylene)s (OPEs) are linked together via one vinylogous linker. These mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5541593c7ecdba5897e7d59b2af065b2
https://doi.org/10.1002/ejoc.201601367

Liquid-Crystalline Properties of Thioesters

Autor: Richard J. Mandle, Martin Drøhse Kilde, Anne Ugleholdt Petersen, Mogens Brøndsted Nielsen, Martyn Jevric, John W. Goodby, Frederik Præstholm Jørgensen

Publikováno v: Australian Journal of Chemistry. 71:422

An extension of a new method for forming thioesters with mesomorphic properties has been described, whereby the treatment of aryl tert-butylthioethers with long-chain acid chlorides in the presence of bismuth triflate afforded simple derivatives in g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a319742c156970d2a48bb78fb504119
https://doi.org/10.1071/ch17540