Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Frederik Otzen"'
Autor:
Dylan Scott Lykke Harwood, Vilde Pedersen, Nicolai Schou Bager, Ane Yde Schmidt, Tobias Overlund Stannius, Aušrinė Areškevičiūtė, Knud Josefsen, Dorte Schou Nørøxe, David Scheie, Hannah Rostalski, Maya Jeje Schuang Lü, Alessio Locallo, Ulrik Lassen, Frederik Otzen Bagger, Joachim Weischenfeldt, Dieter Henrik Heiland, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Bjarne Winther Kristensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy. Malignant cells escape surgical resection by migrating into the surr
Externí odkaz:
https://doaj.org/article/c9a8d9f57fc34c07b292a1cad2634555
Autor:
Christina Bligaard Pedersen, Benito Campos, Lasse Rene, Helene Scheel Wegener, Neeraja M. Krishnan, Binay Panda, Kristoffer Vitting‐Seerup, Maria Rossing, Frederik Otzen Bagger, Lars Rønn Olsen
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 606-619 (2024)
Molecular subtyping is essential to infer tumor aggressiveness and predict prognosis. In practice, tumor profiling requires in‐depth knowledge of bioinformatics tools involved in the processing and analysis of the generated data. Additionally, data
Externí odkaz:
https://doaj.org/article/91af8075ca0347618bf363e33adca13d
Autor:
Frederik Otzen Bagger, Line Borgwardt, Andreas Sand Jespersen, Anna Reimer Hansen, Birgitte Bertelsen, Miyako Kodama, Finn Cilius Nielsen
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers. Compared to other molecular genetic methods, WGS captures most g
Externí odkaz:
https://doaj.org/article/bdac98f0449e44859e7474c9ecbed628
Autor:
Annie Borch, Ibel Carri, Birkir Reynisson, Heli M. Garcia Alvarez, Kamilla K. Munk, Alessandro Montemurro, Nikolaj Pagh Kristensen, Siri A. Tvingsholm, Jeppe Sejerø Holm, Christina Heeke, Keith Henry Moss, Ulla Kring Hansen, Anna-Lisa Schaap-Johansen, Frederik Otzen Bagger, Vinicius Araujo Barbosa de Lima, Kristoffer S. Rohrberg, Samuel A. Funt, Marco Donia, Inge Marie Svane, Ulrik Lassen, Carolina Barra, Morten Nielsen, Sine Reker Hadrup
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMutation-derived neoantigens are critical targets for tumor rejection in cancer immunotherapy, and better tools for neoepitope identification and prediction are needed to improve neoepitope targeting strategies. Computational tools have ena
Externí odkaz:
https://doaj.org/article/0bbbca7628154c30a577b6a43214db8d
Autor:
Victoria Probst, Arman Simonyan, Felix Pacheco, Yuliu Guo, Finn Cilius Nielsen, Frederik Otzen Bagger
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Single cell mRNA sequencing technologies have transformed our understanding of cellular heterogeneity and identity. For sensitive discovery or clinical marker estimation where high transcript capture per cell is needed only plate-
Externí odkaz:
https://doaj.org/article/3fc2aef8910241feb171873744691636
Autor:
Andrea Maier, Lorenzo Perino, Signe Regner Michaelsen, Tobias Overlund Stannius, Jeppe Haslund-Vinding, Nicolai Schou Bager, David Scheie, Ane Yde Schmidt, Ausrine Areškevičiūtė, Knud Elnegaard Josefsen, Frederik Otzen Bagger, Bjarne Winther Kristensen, Tiit Mathiesen
Publikováno v:
Brain and Spine, Vol 3, Iss , Pp 102134- (2023)
Externí odkaz:
https://doaj.org/article/ecaf8d0ef4f540a7991d723a03cd47b7
Autor:
Marek Prachar, Sune Justesen, Daniel Bisgaard Steen-Jensen, Stephan Thorgrimsen, Erik Jurgons, Ole Winther, Frederik Otzen Bagger
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and efficacious vaccine development. Stimulation of a proper immune response that leads to protection is highly dependent on presentation of epitopes to circulati
Externí odkaz:
https://doaj.org/article/2e4f85ebafd44c1a9adb239a6bb78181
Autor:
Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.
Externí odkaz:
https://doaj.org/article/23f6a9ca034c46419734966b67ed3c71
Autor:
Hugues-Etienne Châtel-Soulet, Sabine Juge, Ana Luisa Pereira, Frederik Otzen Bagger, Alexandar Tzankov, Mineo Kurokawa, Athimed El Taher, Jonathan Seguin, César Nombela Arrieta, Juerg Schwaller
Publikováno v:
HemaSphere, Vol 6, Pp 17-18 (2022)
Externí odkaz:
https://doaj.org/article/5447b9dc9a0f4978903020c6b2640e97
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Unsupervised machine learning methods (deep learning) have shown their usefulness with noisy single cell mRNA-sequencing data (scRNA-seq), where the models generalize well, despite the zero-inflation of the data. A class of neural
Externí odkaz:
https://doaj.org/article/3e19d3420d44410db46d089f55470b1e