Humoral and cellular immune response from first to fourth SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients—a longitudinal cohort study

Autor: Frederik Novak, Anna Christine Nilsson, Emil Birch Christensen, Caroline Louise Stougaard, Mike Bogetofte Barnkob, Dorte K. Holm, Agnes Hauschultz Witt, Keld-Erik Byg, Isik S. Johansen, Christian Nielsen, Tobias Sejbaek

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundThis study examines the humoral and cellular response in multiple sclerosis (MS) patients on anti-CD20 therapy before and after the 1st to 4th BNT162b2 mRNA SARS-CoV-2 vaccination and the relationship with breakthrough infection.MethodsPart

Externí odkaz: https://doaj.org/article/4bf15d137f534304ac83518451328cd4

Low protection from breakthrough SARS-CoV-2 infection and mild disease course in ocrelizumab-treated patients with multiple sclerosis after three mRNA vaccine doses

Autor: Frederik Novak, Hamza Mahmood Bajwa, John Eugenio Coia, Anna Christine Nilsson, Christian Nielsen, Dorte K Holm, Kamilla Østergaard, Mathilde Vilhelmine Miller Hvidt, Keld-Erik Byg, Isik S Johansen, Kristen Mittl, William Rowles, Scott S Zamvil, Riley Bove, Joseph J Sabatino, Tobias Sejbaek

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. :jnnp-2022

BackgroundOur study investigated the rate of breakthrough SARS-CoV-2 infection and clinical outcomes in a cohort of multiple sclerosis (MS) patients who were treated with the anti-CD20 monoclonal antibody (Ab), ocrelizumab, before first, second and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8334c8848e07994d199f2eb2f5896b26
https://doi.org/10.1136/jnnp-2022-330757

Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients

Autor: Hamza Mahmood Bajwa, Frederik Novak, Anna Christine Nilsson, Christian Nielsen, Dorte K. Holm, Kamilla Østergaard, Agnes Hauschultz Witt, Keld-Erik Byg, Isik S. Johansen, Kristen Mittl, William Rowles, Scott S. Zamvil, Riley Bove, Joseph J. Sabatino, Tobias Sejbaek

Publikováno v: Bajwa, H M, Novak, F, Nilsson, A C, Nielsen, C, Holm, D K, Østergaard, K, Witt, A H, Byg, K E, Johansen, I S, Mittl, K, Rowles, W, Zamvil, S S, Bove, R, Sabatino, J J & Sejbaek, T 2022, ' Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients ', Multiple Sclerosis and Related Disorders, vol. 60, 103729 . https://doi.org/10.1016/j.msard.2022.103729

ObjectiveTo examine humoral and cellular response in multiple sclerosis patients on anti-CD20 therapy after third BNT162b2 mRNA SARS-CoV-2 vaccination.MethodsA prospective longitudinal study design from first throughout third vaccination in Danish an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21f67fc3fe8b6804b9c4202dd93763a
https://doi.org/10.1016/j.msard.2022.103729

Extended dosage interval of B-cell therapy in multiple sclerosis

Autor: Frederik Novak, Ostergaard, K., Munksgaard Berg, J., Hilt Kristensen, C., Zsolt Illes, Sellebjerg, F., Tobias Sejbaek

Publikováno v: University of Southern Denmark
Novak, F, Ostergaard, K, Berg, J M, Kristensen, C H, Illes, Z, Sellebjerg, F & Sejbaek, T 2021, ' Extended dosage interval of B-cell therapy in multiple sclerosis ', Multiple Sclerosis Journal, vol. 27, no. Suppl. 2, pp. 767 . < https://doi.org/10.1177/13524585211047080 >
Novak, F, Østergaard, K, Berg, J M, Kristensen, C H, Illes, Z, Sellebjerg, F & Sejbaek, T 2021, ' Extended dosage interval of B-cell therapy in multiple sclerosis ', Multiple Sclerosis Journal, vol. 27, no. Suppl. 2, P941, pp. 767 . https://doi.org/10.1177/13524585211047080

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::86c1d22b9f7ba0b9068c18a2ecfe5758
https://portal.findresearcher.sdu.dk/en/publications/f0219333-aa58-4bcb-bb9d-2a2d4154e39f