Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Autor: Eva K. Oernbo, Annette B. Steffensen, Pooya Razzaghi Khamesi, Trine L. Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja H. Simonsen, Sara D. Lolansen, Søren N. Andreassen, Steen G. Hasselbalch, Thomas Zeuthen, Christine R. Rose, Vartan Kurtcuoglu, Nanna MacAulay

Publikováno v: Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-25 (2022)

Abstract Background Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular mechanisms governing

Externí odkaz: https://doaj.org/article/5f05e5d9134e47b3a3b4351767140f5a

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

Autor: Troels Rahbek-Clemmensen, Matthew D. Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N. Jørgensen, Freja H. Hansen, Ulrik Gether

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic

Externí odkaz: https://doaj.org/article/94adb06557e442279abc6255c4796f9c

Novel and Converging Ways of NOX2 and SOD3 in Trafficking and Redox Signaling in Macrophages

Autor: Steen Vang Petersen, Nanna Bach Poulsen, Cecilie Linneberg Matthiesen, Frederik Vilhardt

Publikováno v: Antioxidants, Vol 10, Iss 2, p 172 (2021)

Macrophages and related tissue macrophage populations use the classical NADPH oxidase (NOX2) for the regulated production of superoxide and derived oxidants for pathogen combat and redox signaling. With an emphasis on macrophages, we discuss how sort

Externí odkaz: https://doaj.org/article/e3d425d931d6482db028c0287dc59349

A34 NADPH oxidases putative roles in Huntington’s disease

Autor: Luisana Duque, Izabela Rasmussen, Anne Nørremølle, Frederik Vilhardt, Kristine Freude

Publikováno v: A: Pathogenic mechanisms.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c553419f9fa0bad61dbfbf51ebc5a602
https://doi.org/10.1136/jnnp-2022-ehdn.34

α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

Autor: Helena Borland, Izabela Rasmussen, Kaare Bjerregaard-Andersen, Michel Rasmussen, Anders Olsen, Frederik Vilhardt

Publikováno v: Borland, H, Rasmussen, I, Bjerregaard-Andersen, K, Rasmussen, M, Olsen, A & Vilhardt, F 2022, ' α-synuclein build-up is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α ', Journal of Biological Chemistry, vol. 298, no. 11, 102531 . https://doi.org/10.1016/j.jbc.2022.102531
Borland, H, Rasmussen, I, Bjerregaard-Andersen, K, Rasmussen, M, Olsen, A & Vilhardt, F 2022, ' α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α ', The Journal of Biological Chemistry, vol. 298, no. 11, 102531 . https://doi.org/10.1016/j.jbc.2022.102531

α-synucleinopathy is driven by an imbalance of synthesis and degradation of α-synuclein (αSyn), causing a build up of αSyn aggregates and post-translationally modified species, which not only interfere with normal cellular metabolism but also by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91377a8e5e36a8f4dae8987519206b4f
https://pubmed.ncbi.nlm.nih.gov/36162505