Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Frederik, Stevenaert"'
Autor:
Sara Turcinov, Erik af Klint, Bertrand Van Schoubroeck, Arlette Kouwenhoven, Sohel Mia, Karine Chemin, Hans Wils, Carl Van Hove, An De Bondt, Ken Keustermans, Jeroen Van Houdt, Joke Reumers, Nathan Felix, Navin L. Rao, Pieter Peeters, Frederik Stevenaert, Lars Klareskog, Murray McKinnon, Daniel Baker, Anish Suri, Vivianne Malmström
Publikováno v:
Arthritis & Rheumatology. 75:673-684
Autor:
Theresa Schmid, Miray Cetin, Veronica Pinamonti, Ana Mellado Fuentes, Kristina Kromer, Taga Lerner, Jing Zhang, Tamara Boschert, Yonatan Herzig, Christopher Ehlert, Laura Fisch, Valeriia Dragan, Arlette Kouwenhoven, Bertrand Van Schoubroeck, Hans Wils, Carl Van Hove, Michael Platten, Edward Green, Frederik Stevenaert, Nathan J. Felix, John M. Lindner
Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA-presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applications, yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82919b45ad4a89bdeb0ca5cb007d52b9
https://doi.org/10.1101/2023.05.16.540992
https://doi.org/10.1101/2023.05.16.540992
Autor:
Sara, Turcinov, Erik, Af Klint, Bertrand, Van Schoubroeck, Arlette, Kouwenhoven, Sohel, Mia, Karine, Chemin, Hans, Wils, Carl, Van Hove, An, De Bondt, Ken, Keustermans, Jeroen, Van Houdt, Joke, Reumers, Nathan, Felix, Navin L, Rao, Pieter, Peeters, Frederik, Stevenaert, Lars, Klareskog, Murray, McKinnon, Daniel, Baker, Anish, Suri, Vivianne, Malmström
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
CD4+ T cells are implicated in rheumatoid arthritis (RA) pathology from the strong association between RA and certain HLA-class II gene variants. Here, we studied the synovial T cell receptor (TCR) repertoire, T cell phenotypes and T cell specificiti
Autor:
Murray McKinnon, Nathan J. Felix, Nicole L. La Gruta, Claerwen M. Jones, Vivianne Malmström, Jia Jia Lim, Anthony W. Purcell, Jamie Rossjohn, Tiing Jen Loh, Yi Tian Ting, Daniel Baker, Pirooz Zareie, Lars Klareskog, Khai Lee Loh, Frederik Stevenaert, Anish Suri, Ravi Sharma, Hugh H. Reid
Publikováno v:
Science Immunology. 6
Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens tha
Autor:
Christopher Chiu, Hugo Ceulemans, Torben Plesner, Greet Vanhoof, Jordan M. Schecter, Nizar J. Bahlis, Saad Z. Usmani, Tina Smets, Homer Adams, Andrew C. Lysaght, Yann Abraham, Hervé Avet-Loiseau, Jaime Bald, Frederik Stevenaert, Joshua Rusbuldt, Karl C. Nielsen, Amy Axel, Tuna Mutis, Tineke Casneuf, Inger S. Nijhof, Koen Van der Borght, Brad Foulk, Niels W.C.J. van de Donk
Publikováno v:
Casneuf, T, Adams, H C, van de Donk, N W C J, Abraham, Y, Bald, J, Vanhoof, G, Van der Borght, K, Smets, T, Foulk, B, Nielsen, K C, Rusbuldt, J, Axel, A, Lysaght, A, Ceulemans, H, Stevenaert, F, Usmani, S Z, Plesner, T, Avet-Loiseau, H, Nijhof, I, Mutis, T, Schecter, J M, Chiu, C & Bahlis, N J 2021, ' Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab ', Leukemia, vol. 35, no. 2, pp. 573-584 . https://doi.org/10.1038/s41375-020-0855-4
Leukemia
Leukemia, 35(2), 573-584. Nature Publishing Group
Casneuf, T, Adams, H C, van de Donk, N W C J, Abraham, Y, Bald, J, Vanhoof, G, Van der Borght, K, Smets, T, Foulk, B, Nielsen, K C, Rusbuldt, J, Axel, A, Lysaght, A, Ceulemans, H, Stevenaert, F, Usmani, S Z, Plesner, T, Avet-Loiseau, H, Nijhof, I, Mutis, T, Schecter, J M, Chiu, C & Bahlis, N J 2021, ' Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab ', Leukemia, vol. 35, pp. 573-584 . https://doi.org/10.1038/s41375-020-0855-4
Leukemia
Leukemia, 35(2), 573-584. Nature Publishing Group
Casneuf, T, Adams, H C, van de Donk, N W C J, Abraham, Y, Bald, J, Vanhoof, G, Van der Borght, K, Smets, T, Foulk, B, Nielsen, K C, Rusbuldt, J, Axel, A, Lysaght, A, Ceulemans, H, Stevenaert, F, Usmani, S Z, Plesner, T, Avet-Loiseau, H, Nijhof, I, Mutis, T, Schecter, J M, Chiu, C & Bahlis, N J 2021, ' Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab ', Leukemia, vol. 35, pp. 573-584 . https://doi.org/10.1038/s41375-020-0855-4
CD38-targeted antibody, daratumumab, is approved for the treatment of multiple myeloma (MM). Phase 1/2 studies GEN501/SIRIUS revealed a novel immunomodulatory mechanism of action (MOA) of daratumumab that enhanced the immune response, reducing natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6476f20835a97bd61e5db396f8b77608
https://research.vumc.nl/en/publications/534ff20f-4ef5-47f0-a75d-98f650c178d0
https://research.vumc.nl/en/publications/534ff20f-4ef5-47f0-a75d-98f650c178d0
Autor:
Torben Plesner, Saad Z. Usmani, Koen Van der Borght, Homer Adams, Greet Vanhoof, Amy Sasser, Henk M. Lokhorst, Tineke Casneuf, Jakub Krejcik, Inger S. Nijhof, Tina Smets, Christopher Chiu, Hugo Ceulemans, Sagar Lonial, Niels W.C.J. van de Donk, Tuna Mutis, Frederik Stevenaert, Yann Abraham, Jaime Bald
Publikováno v:
Adams, H C, Stevenaert, F, Krejcik, J, Van der Borght, K, Smets, T, Bald, J, Abraham, Y, Ceulemans, H, Chiu, C, Vanhoof, G, Usmani, S Z, Plesner, T, Lonial, S, Nijhof, I, Lokhorst, H M, Mutis, T, van de Donk, N W C J, Sasser, A K & Casneuf, T 2019, ' High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action ', Cytometry. Part A, vol. 95, no. 3, pp. 279-289 . https://doi.org/10.1002/cyto.a.23693
Cytometry Part A, 95(3), 279-289
Adams, H C, Stevenaert, F, Krejcik, J, Van der Borght, K, Smets, T, Bald, J, Abraham, Y, Ceulemans, H, Chiu, C, Vanhoof, G, Usmani, S Z, Plesner, T, Lonial, S, Nijhof, I, Lokhorst, H M, Mutis, T, van de Donk, N W C J, Sasser, A K & Casneuf, T 2019, ' High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action ', Cytometry Part A, vol. 95, no. 3, pp. 279-289 . https://doi.org/10.1002/cyto.a.23693
Cytometry Part A, 95(3), 279-289
Adams, H C, Stevenaert, F, Krejcik, J, Van der Borght, K, Smets, T, Bald, J, Abraham, Y, Ceulemans, H, Chiu, C, Vanhoof, G, Usmani, S Z, Plesner, T, Lonial, S, Nijhof, I, Lokhorst, H M, Mutis, T, van de Donk, N W C J, Sasser, A K & Casneuf, T 2019, ' High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action ', Cytometry Part A, vol. 95, no. 3, pp. 279-289 . https://doi.org/10.1002/cyto.a.23693
Daratumumab is a CD38-targeted human monoclonal antibody with direct anti-myeloma cell mechanisms of action. Flow cytometry in relapsed and/or refractory multiple myeloma (RRMM) patients treated with daratumumab revealed cytotoxic T-cell expansion an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b1d8fa08423cee70f92f2f3a32022b
https://findresearcher.sdu.dk:8443/ws/files/149065141/High_Parameter_Mass_Cytometry_Evaluation_of_....pdf
https://findresearcher.sdu.dk:8443/ws/files/149065141/High_Parameter_Mass_Cytometry_Evaluation_of_....pdf
Autor:
Kurt R. Brunden, Bryan Zoll, Diederik Moechars, Alex Crowe, Virginia M.-Y. Lee, Joshua P. Daniels, Frederik Stevenaert, Alberto M. Soares, Kathleen Callaerts, Sara Calafate, Jing L. Guo, Arjan Buist
Publikováno v:
Journal of Biological Chemistry. 291:13175-13193
Filamentous tau aggregates, the hallmark lesions of Alzheimer disease (AD), play key roles in neurodegeneration. Activation of protein degradation systems has been proposed to be a potential strategy for removing pathological tau, but it remains uncl
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1792
Mass cytometry has emerged as a new state-of-the-art technology that enables in-depth characterization of cellular populations and functions at a single cell resolution. We describe the application of this technology to deeply phenotype the blood and
Publikováno v:
Methods in Molecular Biology ISBN: 9781493978649
Mass cytometry has emerged as a new state-of-the-art technology that enables in-depth characterization of cellular populations and functions at a single cell resolution. We describe the application of this technology to deeply phenotype the blood and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff2f52d0621fbb357ddc1f979294df0
https://doi.org/10.1007/978-1-4939-7865-6_4
https://doi.org/10.1007/978-1-4939-7865-6_4
Autor:
Jing L, Guo, Arjan, Buist, Alberto, Soares, Kathleen, Callaerts, Sara, Calafate, Frederik, Stevenaert, Joshua P, Daniels, Bryan E, Zoll, Alex, Crowe, Kurt R, Brunden, Diederik, Moechars, Virginia M Y, Lee
Publikováno v:
The Journal of biological chemistry. 291(25)
Filamentous tau aggregates, the hallmark lesions of Alzheimer disease (AD), play key roles in neurodegeneration. Activation of protein degradation systems has been proposed to be a potential strategy for removing pathological tau, but it remains uncl