Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Frederico Severino Martins"'
1
Akademický článek
Advancing Virtual Bioequivalence for Orally Administered Drug Products: Methodology, Real-World Applications and Future Outlook
Autor: Sivacharan Kollipara, Frederico Severino Martins, Rebeka Jereb, Dejan Krajcar, Tausif Ahmed
Publikováno v: Pharmaceuticals, Vol 17, Iss 7, p 876 (2024)
Bioequivalence studies are pivotal in generic drug development wherein therapeutic equivalence is provided with an innovator product. However, bioequivalence studies represent significant complexities due to the interplay of multiple factors related
Externí odkaz: https://doaj.org/article/8b2b97b7b6c94d8384c6b9e8d5b46e52
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2
Akademický článek
Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy
Autor: Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Josmar Mazucheli, Sheila Alexandra Belini Nishiyama, Floristher Elaine Carrara-Marroni, Frederico Severino Martins, Peijuan Zhu, Mingming Yu, Sherwin Kenneth B. Sy, Maria Cristina Bronharo Tognim
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfo
Externí odkaz: https://doaj.org/article/1982216eca7d4de6a53da43ee6b273c2
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3
Akademický článek
Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters
Autor: Leonardo Luiz Borges, Frederico Severino Martins, João José Franco, Elisa Flávia Luiz Cardoso Bailão, Wilson de Melo Cruvinel, Sérgio Akira Uyemura, Edemilson Cardoso da Conceição
Publikováno v: Brazilian Journal of Biology, Vol 83 (2021)
Abstract Plinia cauliflora (Mart.) Kausel, popularly known as jabuticaba, is rich in polyphenols. Phenolic compounds exhibit several biological properties, which reflect on biomarkers such as biochemical parameters. In the present study, we evaluated
Externí odkaz: https://doaj.org/article/5671249537844737aba49744a931fbdd
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5
Akademický článek
Characterization of rue extract and its potential for controlling rice blast
Autor: Karinna Bannach Reis, Marcio Vinicius de Carvalho Barros Côrtes, Frederico Severino Martins, Marta Cristina Corsi de Filippi, José Realino de Paula, Edemilson Cardoso da Conceição
Publikováno v: Pesquisa Agropecuária Brasileira, Vol 50, Iss 12, Pp 1121-1130 (2015)
Abstract: The objective of this work was to purify and standardize the rue (Ruta graveolens) extract and evaluate its effect on Magnaporthe oryzae as an alternative to the integrated management of rice blast. The drug was characterized, the liquid ex
Externí odkaz: https://doaj.org/article/29b45bbf9f7341ea9eec10282f67c859
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6
Physiologically based pharmacokinetic‐pharmacodynamic evaluation of meropenem plus fosfomycin in paediatrics
Autor: Peijuan Zhu, M. Tobias Heinrichs, Frederico Severino Martins, Sherwin K. B. Sy
Publikováno v: British Journal of Clinical Pharmacology. 87:1012-1023
Aims The objective of the current study was to evaluate paediatric dosing regimens for meropenem plus fosfomycin that generate sufficient coverage against multidrug-resistant bacteria. Methods The physiologically based pharmacokinetic (PBPK) models o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25b46e64d311ec99a69c714cc1a3326
https://doi.org/10.1111/bcp.14456
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7
Melanogenic Effect and Toxicity Assessments of Standardized Extract of Brosimum gaudichaudii
Autor: Maria José Vieira Fonseca, Frederico Severino Martins, Edemilson Cardoso da Conceição, Sherwin K. B. Sy, Osvaldo de Freitas
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brosimum gaudichaudii Trecul, Moraceae, is a Brazilian plant species used in traditional medicine to treat vitiligo or as an additive in natural suntan lotions. Even though it is widely used in Brazil, its safety and efficacy have not been studied. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097cfb7555093026b769b08c03774f8e
https://doi.org/10.1007/s43450-020-00078-6
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8
Akademický článek
Isolation and quantitative HPLC-PDA analysis of lupeol in phytopharmaceutical intermediate products from Vernonanthura ferruginea (Less.) H. Rob.
Autor: Ezequiane Machado Silva Oliveira, Sabrine Lemes Freitas, Frederico Severino Martins, Renê Oliveira Couto, Mariana Viana Pinto, José Realino Paula, Edemilson Cardoso Conceição, Maria Teresa Freitas Bara
Publikováno v: Química Nova, Vol 35, Iss 5, Pp 1041-1045 (2012)
Prior to obtain a standardized dried extract from V. ferruginea, lupeol was first time isolated from leaves and used as chemical maker. An analytical method using HPLC-PDA for lupeol determination in V. ferruginea intermediate products was developed
Externí odkaz: https://doaj.org/article/2df8a2a7a0e94e8080f98b8d7fe7fb68
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9
Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters
Autor: Frederico Severino Martins, Sérgio Akira Uyemura, Elisa Flávia Luiz Cardoso Bailão, João José Franco, Edemilson Cardoso da Conceição, Wilson de Melo Cruvinel, Leonardo Luiz Borges
Publikováno v: Brazilian Journal of Biology, Volume: 83, Article number: e242439, Published: 27 AUG 2021
Brazilian Journal of Biology v.83 2023
Brazilian Journal of Biology
Instituto Internacional de Ecologia (IIE)
instacron:IIE
Brazilian Journal of Biology, Vol 83 (2021)
Plinia cauliflora (Mart.) Kausel, popularly known as jabuticaba, is rich in polyphenols. Phenolic compounds exhibit several biological properties, which reflect on biomarkers such as biochemical parameters. In the present study, we evaluated the plas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41367ba19db27208a2763b44fe0efba1
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100173&lng=en&tlng=en
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10
Evaluation of the drug-drug interaction potential of treosulfan using a physiologically-based pharmacokinetic modelling approach
Autor: Pavel Balazki, Sonja Böhm, Dietrich W. Beelen, Frederico Severino Martins, Stephan Schaller, Joachim Baumgart, Arne Ring, Ralf A. Hilger, Claudia Hemmelmann
Publikováno v: British journal of clinical pharmacology. 88(4)
Aims: The aim of this work is the development of a mechanistic physiologically-based pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation to conduct a drug-drug interaction (DDI) assessment of treosulfan against two cytochrome p450 (C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0d7bd430278c1a4bf5ab2f371ec4e
https://pubmed.ncbi.nlm.nih.gov/34519068
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