Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Frederico Nardi"'
1
Abstract 4024: NAMPT inhibitor decreases NAMPT capture by an antibody directed against the 5-phosphoribosyl-1-pyrophosphate-binding loop: Rationale for an NAMPT occupancy assay
Autor: Thomas Bertrand, Maysoun Shomali, Laurent Debussche, Marianne Duhamel, Sandrine Hilairet, Geraldine Penarier, Frederico Nardi, Monsif Bouaboula
Publikováno v: Cancer Research. 80:4024-4024
Nicotinamide phosphoribosyl transferase (NAMPT) catalyzes the rate-limiting step of nicotinamide adenine dinucleotide (NAD) biosynthesis. As NAMPT inhibitors (NAMPTi) have been shown to be substrates of NAMPT, binding of NAMPTi to NAMPT results in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7aa11f1fbe50f7c5344c84edf61fd65
https://doi.org/10.1158/1538-7445.am2020-4024
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3
Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure–Activity Relationships
Autor: Loreley Calvet, Sabine Haag-Richter, Frederico Nardi, Peer Lukat, Patricia Vrignaud, Jean-Paul Nicolas, Jidong Zhang, Irene Kochems, Silke C. Wenzel, Mark Brönstrup, Tietgen Heiko, Michael Kurz, Laurent Debussche, Dietmar Schummer, Valerie Czepczor, Stefan Pelzer, Rolf Müller, Holger Hoffmann, Agnes Mühlenweg
Publikováno v: Angewandte Chemie International Edition. 54:15560-15564
The bengamides, sponge-derived natural products that have been characterized as inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as anticancer compounds. We embarked on a multidisciplinary project to supply bengam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c9fd59d158210a5e3729cdf4831bbe
https://doi.org/10.1002/anie.201508277
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4
Use of vibrational spectroscopy to study protein and DNA structure, hydration, and binding of biomolecules: A combined theoretical and experimental approach
Autor: Frank Herrmann, Michaela Knapp-Mohammady, V. Würtz Jürgensen, K. Frimand, Risto M. Nieminen, C. Jung, Thomas A. Niehaus, A. Rahim, Sándor Suhai, Anetta Claussen, G. M. Jensen, Frederico Nardi, Karl J. Jalkanen, Ivan Degtyarenko, Rebecca C. Wade
Publikováno v: International Journal of Quantum Chemistry. 106:1160-1198
We report on our work with vibrational absorption, vibrational circular dichroism, Raman scattering, Raman optical activity, and surface-enhanced Raman spectroscopy to study protein and DNA structure, hydration, and the binding of ligands, drugs, pes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cd3fb70eada50931fe144d11850d53c
https://doi.org/10.1002/qua.20863
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5
[Untitled]
Autor: Rebecca C. Wade, Johan Kemmink, Frederico Nardi, Michael Sattler
Publikováno v: Journal of Biomolecular NMR. 17:63-77
Cisproline(i−1)-aromatic(i) interactions have been detected in several short peptides in aqueous solution by analysis of anomalous chemical shifts measured by 1H-NMR spectroscopy. This formation of local structure is of importance for protein foldi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0368717ec9a06dd0320fa4e017baa600
https://doi.org/10.1023/a:1008380807603
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6
L-Alanyl-L-alanine in the zwitterionic state: structures determined in the presence of explicit water molecules and with continuum models using density functional theory
Autor: Frederico Nardi, Michaela Knapp-Mohammady, Karl J. Jalkanen, Sándor Suhai, Rebecca C. Wade
Publikováno v: Scopus-Elsevier
The structures and relative energies for L-alanyl-L-alanine (LALA) in the presence of explicit water molecules have been determined by using the density functional theory (DFT) Becke3–Lee–Yang–Parr functional and the 6-31G* basis set (B3LYP/6-3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e89aec54f8416fe2905035c3f8cdd2
https://doi.org/10.1016/s0301-0104(98)00387-5
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7
Use of Multiple Molecular Dynamics Trajectories To Study Biomolecules in Solution: The YTGP Peptide
Autor: Rebecca C. Wade, Graham A. Worth, Frederico Nardi
Publikováno v: The Journal of Physical Chemistry B. 102:6260-6272
NMR studies of the YTGP tetrapeptide in aqueous solution show a large structural shift on the glycine peptide proton, indicating that the peptide adopts structures in which the aromatic ring lies close to this proton in an aromatic−(i+2) amine inte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::870e030bb19e0f473ff4396b006512f4
https://doi.org/10.1021/jp9808532
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8
Dynamics of sulfonated ionomers in the solid state: inelastic neutron scattering studies
Autor: Barbara J. Gabrys, John Tomkinson, Frederico Nardi, Dong Huang, Dennis G. Peiffer
Publikováno v: Macromolecules. 26:2007-2011
An inelastic neutron scattering study was performed on arctic and isotactic polystyrene (PS) and sodium sulfonated polystyrene. Vibrational modes due to the ring and chain moieties mere identified by the process of selective deuteration. It was found
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d9c6973b2f2ecbfbc1549df7022d53f
https://doi.org/10.1021/ma00060a032
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10
Local interactions of aromatic residues in short peptides in aqueous solution: a combined database and energetic analysis
Autor: Rebecca C. Wade, Graham A. Worth, Frederico Nardi
Publikováno v: Foldingdesign. 2(4)
Although short peptides are usually structurally disordered in aqueous solution, particular peptide sequences display local structure. We performed database and conformational searches, along with molecular dynamics simulations, to study two local in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09152fb055e84f78dfd02702d86fc9e
https://pubmed.ncbi.nlm.nih.gov/9269571
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