Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Frederico Aires da Silva"'
Autor:
Maria Cristina Barroso, Andreia Grilo, Sandra Aguiar, Frederico Aires da Silva, Berta São Braz
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The impact of drug transporters in veterinary medicine has been recognized in recent years. One of the most well-characterized is the product of the MDR1 gene, P-gp. A 4-bp deletion in the MDR1 gene known since 2001 has been described to affect herdi
Externí odkaz:
https://doaj.org/article/3fd3f64bb9ac4bfaa70cf5594c0e63f8
Autor:
Rita Calado, Joana Duarte, Pedro Borrego, José Maria Marcelino, Inês Bártolo, Francisco Martin, Inês Figueiredo, Silvia Almeida, Luís Graça, Jorge Vítor, Frederico Aires da Silva, Inês Dias, Belmira Carrapiço, Nuno Taveira
Publikováno v:
Vaccines, Vol 8, Iss 2, p 171 (2020)
Development of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced V
Externí odkaz:
https://doaj.org/article/5418695cb88a43149c66c422719e0bad
Autor:
Magda Ferreira, Margarida Pinto, Frederico Aires-da-Silva, Ana Bettencourt, Maria Manuela Gaspar, Sandra Isabel Aguiar
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Staphylococcus aureus poses a significant threat as an opportunistic pathogen in humans, and animal medicine, particularly in the context of hospital-acquired infections (HAIs). Effective treatment is a significant challenge, contributing substantial
Externí odkaz:
https://doaj.org/article/13c993ac406441868bf5a22703301920
Autor:
Ana S. André, Joana N. R. Dias, Sandra Aguiar, Sara Nogueira, Pedro Bule, Joana Inês Carvalho, João P. M. António, Marco Cavaco, Vera Neves, Soraia Oliveira, Gonçalo Vicente, Belmira Carrapiço, Berta São Braz, Barbara Rütgen, Lurdes Gano, João D. G. Correia, Miguel Castanho, Joao Goncalves, Pedro M. P. Gois, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop mor
Externí odkaz:
https://doaj.org/article/f9c1a085d74e4cbdaf2217e2c95385f7
Autor:
Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Ana Leonardo, Sara Nogueira, Joana D. Amaral, Célia Fernandes, Lurdes Gano, João D. G. Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionCancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparati
Externí odkaz:
https://doaj.org/article/e1ae62f371ba4be582f085b5e995f720
Autor:
Joana N. R. Dias, André Almeida, Ana S. André, Sandra I. Aguiar, Pedro Bule, Sara Nogueira, Soraia S. Oliveira, Belmira Carrapiço, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Anti-CD20 therapies have revolutionized the treatment of B-cell malignancies. Despite these advances, relapsed and refractory disease remains a major treatment challenge. The optimization of CD20-targeted immunotherapies is considered a prom
Externí odkaz:
https://doaj.org/article/ccec3d367937465e89f52aafc3853533
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The discovery of hybridoma technology, described by Kohler and Milstein in 1975, and the resulting ability to generate monoclonal antibodies (mAbs) initiated a new era in antibody research and clinical development. However, limitations of the hybrido
Externí odkaz:
https://doaj.org/article/123a998e52ef41de80fa85bbf91ca29a
Autor:
Joana N. R. Dias, Ana S. André, Sandra I. Aguiar, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
The new era of immune-oncology has brought complexities and challenges that emphasize the need to identify new strategies and models to develop successful and cost-effective therapies. The inclusion of a canine model in the drug development of cancer
Externí odkaz:
https://doaj.org/article/b91f2964e9dd42668c690e937047549a
Autor:
Claudia Istrate, Jéssica Marques, Pedro Bule, Sílvia Correia, Frederico Aires-da-Silva, Marlene Duarte, Ana Luísa Reis, Miguel Machuqueiro, Alexandre Leitão, Bruno L. Victor
Publikováno v:
Viruses, Vol 14, Iss 11, p 2348 (2022)
African swine fever virus (ASFV) is the etiological agent of a highly contagious, hemorrhagic infectious swine disease, with a tremendous sanitary and economic impact on a global scale. Currently, there are no globally available vaccines or treatment
Externí odkaz:
https://doaj.org/article/f3252d7cafb54d978fbf47db433d8349
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9804 (2021)
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the tumor, thereby shaping the tumor microenvironment immune prof
Externí odkaz:
https://doaj.org/article/2e50dcd6ccda4c568e5c2bf07aec6335