Výsledky vyhledávání - "Frederico A.V. Castro"

Synthesis, characterization and biological activity of gallium(III) complexes with non-symmetrical NO-donor Schiff bases

Autor: Diego S. Padilha, Jackson A. L. C. Resende, Alexandre B. Rocha, Marciela Scarpellini, Letícia C. Giacomin, Marcos D. Pereira, Frederico A.V. Castro, Yan F. Santos

Publikováno v: Polyhedron. 123:480-489

Cisplatin and its analogues are some of the most widely used anticancer drugs. However, toxicity and resistance have limited their use, and gallium compounds have emerged as an alternative, due to their remarkable antitumor activity and low toxicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7db2d08530ca9d6224bb89b245b1de2c
https://doi.org/10.1016/j.poly.2016.12.020

Zobrazit plný text záznamu

Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae

Autor: Frederico A.V. Castro, Marcos D. Pereira, Gabriel Marques de Souza

Publikováno v: Folia microbiologica. 65(1)

Over the years, quinones or its derivatives have been extensively studied due to their broad therapeutic spectrum. However, due to the significant structural differences between the individual naturally occurring quinones, investigation of the precis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669de8c95c1cff18e78f581f6685ba24
https://pubmed.ncbi.nlm.nih.gov/31183610

Zobrazit plný text záznamu

Azido- and chlorido-cobalt complex as carrier-prototypes for antitumoral prodrugs

Autor: Roberto B. Faria, Frederico A.V. Castro, Amanda dos S. Cavalcanti, Marcos D. Pereira, Marciela Scarpellini, Letícia C. Giacomin, Bianca M. Pires, Adailton J. Bortoluzzi

Publikováno v: Journal of Inorganic Biochemistry. 157:104-113

Cobalt(III) complexes are well-suited systems for cytotoxic drug release under hypoxic conditions. Here, we investigate the effect of cytotoxic azide release by cobalt-containing carrier-prototypes for antitumoral prodrugs. In addition, we study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e584469994ab123570fa94d24abdf95
https://doi.org/10.1016/j.jinorgbio.2016.01.024

Zobrazit plný text záznamu

Protection against cisplatin in calorie-restrictedSaccharomyces cerevisiaeis mediated by the nutrient-sensor proteins Ras2, Tor1, or Sch9 through its target Glutathione

Autor: Marcos D. Pereira, Frederico A.V. Castro, Fernanda L. Fonseca, Luciana G. Almeida, Diana Mariani

Publikováno v: FEMS Yeast Research. 14:1147-1159

There is substantial interest in developing alternative strategies for cancer chemotherapy aiming to increase drug specificity and prevent tumor resistance. Calorie restriction (CR) has been shown to render human cancer cells more susceptible to drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6a358c8094749ce9742508d33f73e6
https://doi.org/10.1111/1567-1364.12214

Zobrazit plný text záznamu

Brazilian propolis protects Saccharomyces cerevisiae cells against oxidative stress

Autor: Elis C. A. Eleutherio, Joaquim F. M. da Silva, Frederico A.V. Castro, Marcos D. Pereira, Raquel Maria Baptista Souza de Souza, Rafael A. de Sá

Publikováno v: Brazilian Journal of Microbiology, Vol 44, Iss 3, Pp 993-1000 (2013)
Brazilian Journal of Microbiology
Brazilian Journal of Microbiology, Volume: 44, Issue: 3, Pages: 1000-993, Published: 17 DEC 2013
Brazilian Journal of Microbiology v.44 n.3 2013
Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM

Propolis is a natural product widely used for humans. Due to its complex composition, a number of applications (antimicrobial, antiinflammatory, anesthetic, cytostatic and antioxidant) have been attributed to this substance. Using Saccharomyces cerev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c94556890a10b61d48fb07822130d12
https://doi.org/10.1590/s1517-83822013005000062

Zobrazit plný text záznamu

Protective effects of flavonoids and extract from Vellozia kolbekii Alves against oxidative stress induced by hydrogen peroxide in yeast

Autor: Lidilhone Hamerski, Camilla Dayane F. Carvalho, Elis C. A. Eleutherio, Ruy José Válka Alves, Carmelita Gomes da Silva, Claudia M. Rezende, Carlos R. Kaiser, Frederico A.V. Castro

Publikováno v: Journal of Natural Medicines. 66:367-372

Two flavonoids 3,5,7,3',4'-pentahydroxy-6-prenylflavonol (1) and 3,5,7,3',4'-pentahydroxy-8-methyl-6-prenylflavonol (2) were isolated from the ethyl acetate extract of sheaths of Vellozia kolbekii Alves (Velloziaceae). This is the first time that com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779b30c6b1715fead1417a0d0a3f7226
https://doi.org/10.1007/s11418-011-0585-z

Zobrazit plný text záznamu

Synthesis, characterization and biological activities of mononuclear Co(III) complexes as potential bioreductively activated prodrugs

Autor: Sergio Machado, Carlos B. Pinheiro, Lorenzo do Canto Visentin, Marcos D. Pereira, Marciela Scarpellini, Elizabeth T. Souza, Lidiane Cavalcante Castro, Frederico A.V. Castro

Publikováno v: Journal of Inorganic Biochemistry. 103:1355-1365

Aiming to investigate the use of tridentate ligands to develop new bireductively activated prodrugs, two N 2 O-donor ligands ( HL1 : [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine; and HL2 : [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e84d97ce12034384fa2428483a86a49
https://doi.org/10.1016/j.jinorgbio.2009.07.008

Zobrazit plný text záznamu

Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases

Autor: Elis C. A. Eleutherio, Frederico A.V. Castro, Anita D. Panek, Marcos D. Pereira, R.S. Herdeiro

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1770:213-220

Using S. cerevisiae as a eukaryotic cell model we have analyzed the involvement of both glutathione transferase isoforms, Gtt1 and Gtt2, in constitutive resistance and adaptive response to menadione, a quinone which can exert its toxicity as redox cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b30317544e8d23e2c4e6968f0cf468
https://doi.org/10.1016/j.bbagen.2006.10.013

Zobrazit plný text záznamu

A study on the properties and reactivity of naphthoquinone-cobalt(III) prototypes for bioreductive prodrugs

Autor: Fabio S. Miranda, Frederico A.V. Castro, Francisco L. S. Bustamante, Mauricio Lanznaster, Marcos D. Pereira, Jackson A. L. C. Resende

Publikováno v: Journal of inorganic biochemistry. 132

Our group has recently initiated a study on the development of new prototypes for bioreductive prodrugs, based on Co(III) complexes with the ligand 2,2'-bis(3-hydroxy-1,4-naphthoquinone), H2bhnq. The focus of this work is to investigate the dissociat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760879e25891921aea1555ab968f87e
https://pubmed.ncbi.nlm.nih.gov/24326134

Zobrazit plný text záznamu

Lawsone dimerization in cobalt(III) complexes toward the design of new prototypes of bioreductive prodrugs

Autor: Frederico A.V. Castro, Francisco L. S. Bustamante, Mauricio Lanznaster, Julia M. Metello, Carlos B. Pinheiro, Marcos D. Pereira

Publikováno v: Inorganic chemistry. 52(3)

Dimerization of lawsone occurs upon reaction with Co(BF(4))(2)·6H(2)O and N,N'-bis(pyridin-2-ylmethyl)ethylenediamine (py(2)en) to produce the mononuclear complex [Co(III)(bhnq)(py(2)en)]BF(4)·H(2)O (1). This complex has been investigated as a prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9326cc4c4e1e4fcca196d1a9dc1a3cb0
https://pubmed.ncbi.nlm.nih.gov/23343393

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání