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The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays key roles in diverse cellular activities and promotes cell growth and survival. It is therefore unsurprising that most viruses modify this pathway in order to facilitate their repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7893942f2cc7cc71cb1ff738fb40c6a
https://europepmc.org/articles/PMC4054420/
https://europepmc.org/articles/PMC4054420/
Publikováno v:
Journal of virology. 87(20)
Previous studies have shown that the abundant herpes simplex virus 1 (HSV-1) tegument protein VP11/12, encoded by gene UL46, stimulates phosphatidylinositol 3-kinase (PI3-kinase)/Akt signaling: it binds the Src family kinase (SFK) Lck, is tyrosine ph