Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Frederick W. HOLTSBERG"'
Autor:
Kevin E. Ramos, Nisreen M. A. Okba, Jessica Tan, Pooja Bandawane, Philip S. Meade, Madhumathi Loganathan, Benjamin Francis, Sergey Shulenin, Frederick W. Holtsberg, M. Javad Aman, Meagan McMahon, Florian Krammer, Jonathan R. Lai
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and treatment of influenza virus infection. There are two major glycoproteins on the influenza virion surface: hemagglutinin (HA), which is responsible fo
Externí odkaz:
https://doaj.org/article/e51458b0b781478a9593e39a21359443
Autor:
Krista Meserve, Abraham J. Qavi, M. Javad Aman, Hong Vu, Larry Zeitlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Lan Yang, Frederick W. Holtsberg, Gaya K. Amarasinghe, Ryan C. Bailey
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101719- (2022)
Summary: This protocol describes the use of silicon photonic microring resonator sensors for detection of Ebola virus (EBOV) and Sudan virus (SUDV) soluble glycoprotein (sGP). This protocol encompasses biosensor functionalization of silicon microring
Externí odkaz:
https://doaj.org/article/e9bbcc7f59114f908957058b53e324a5
Autor:
Jennifer M. Brannan, Shihua He, Katie A. Howell, Laura I. Prugar, Wenjun Zhu, Hong Vu, Sergey Shulenin, Shweta Kailasan, Henna Raina, Gary Wong, Md Niaz Rahim, Logan Banadyga, Kevin Tierney, Xuelian Zhao, Yuxing Li, Frederick W. Holtsberg, John M. Dye, Xiangguo Qiu, M. Javad Aman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV). Here, authors develop cocktails of mAbs that protect nonhuman primates against EBOV, SU
Externí odkaz:
https://doaj.org/article/b99aa7a0e5ce4018ab41eac4e31287f3
Autor:
Hatice Karauzum, Arundhathi Venkatasubramaniam, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Ipsita Mukherjee, Mark Mednikov, Roger Ortines, Nhu T. Q. Nguyen, Thien M. N. Doan, Binh An Diep, Jean C. Lee, M. Javad Aman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Staphylococcus aureus causes a wide range of diseases from skin infections to life threatening invasive diseases such as bacteremia, endocarditis, pneumonia, surgical site infections, and osteomyelitis. Skin infections such as furuncles, carbuncles,
Externí odkaz:
https://doaj.org/article/5acc92f49b3f477d92f2e62b58561d28
Autor:
Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Staphylococcus aureus is a leading cause of significant morbidity and mortality and an enormous economic burden to public health worldwide. Infections caused by methicillin-resistant S. aureus (MRSA) pose a major threat as MRSA strains are becoming i
Externí odkaz:
https://doaj.org/article/c83a2f964899456781ac389d4bee43fb
Autor:
J. Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J. Stafford, Celine Cheng, Grant C. Liao, Frederick W. Holtsberg, M. Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J. Doranz, Aaron C. Brault
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11 (2020)
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Externí odkaz:
https://doaj.org/article/7d64e40551354cef9533f66669faea1e
Autor:
Amanda L. Phelps, Lyn M. O’Brien, David O. Ulaeto, Frederick W. Holtsberg, Grant C. Liao, Robin Douglas, M. Javad Aman, Pamela J. Glass, Crystal L. Moyer, Jane Ennis, Larry Zeitlin, Les P. Nagata, Wei-Gang Hu
Publikováno v:
Viruses, Vol 13, Iss 11, p 2231 (2021)
The three encephalitic alphaviruses, namely, the Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, and WEEV), are classified by the Centers for Disease Control and Prevention (CDC) as biothreat agents. Currently, no licensed m
Externí odkaz:
https://doaj.org/article/6ec4ebe7d4ff40a28edf02bb0e3756d7
Autor:
Katie A. Howell, Jennifer M. Brannan, Christopher Bryan, Andrew McNeal, Edgar Davidson, Hannah L. Turner, Hong Vu, Sergey Shulenin, Shihua He, Ana Kuehne, Andrew S. Herbert, Xiangguo Qiu, Benjamin J. Doranz, Frederick W. Holtsberg, Andrew B. Ward, John M. Dye, M. Javad Aman
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 413-424 (2017)
Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neut
Externí odkaz:
https://doaj.org/article/7ca7c530eb354ec98eeecc1dafcd0526
Autor:
Katie A. Howell, Xiangguo Qiu, Jennifer M. Brannan, Christopher Bryan, Edgar Davidson, Frederick W. Holtsberg, Anna Z. Wec, Sergey Shulenin, Julia E. Biggins, Robin Douglas, Sven G. Enterlein, Hannah L. Turner, Jesper Pallesen, Charles D. Murin, Shihua He, Andrea Kroeker, Hong Vu, Andrew S. Herbert, Marnie L. Fusco, Elisabeth K. Nyakatura, Jonathan R. Lai, Zhen-Yong Keck, Steven K.H. Foung, Erica Ollmann Saphire, Larry Zeitlin, Andrew B. Ward, Kartik Chandran, Benjamin J. Doranz, Gary P. Kobinger, John M. Dye, M. Javad Aman
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1514-1526 (2016)
Summary: Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM0
Externí odkaz:
https://doaj.org/article/8cb2b4542b0546a695db88b408e10d26
Autor:
Shweta Kailasan, Thomas Kort, Ipsita Mukherjee, Grant C. Liao, Tulasikumari Kanipakala, Nils Williston, Nader Ganjbaksh, Arundhathi Venkatasubramaniam, Frederick W. Holtsberg, Hatice Karauzum, Rajan P. Adhikari, M. Javad Aman
Publikováno v:
Toxins, Vol 11, Iss 6, p 339 (2019)
Staphylococcus aureus (SA) infections cause high mortality and morbidity in humans. Being central to its pathogenesis, S. aureus thwarts the host defense by secreting a myriad of virulence factors, including bicomponent, pore-forming leukotoxins. Whi
Externí odkaz:
https://doaj.org/article/c6f398503f794613afe09b6beeb975f9