Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frederick Valeriote"'
Publikováno v:
Molecular Cancer Therapeutics. 22:381-392
FDA-approved enzalutamide is commonly prescribed to reduce the growth of advanced prostate cancer by blocking androgen receptor function. However, enzalutamide-resistant prostate cancer (ERPC) invariably develops and progresses to metastatic, lethal
Supplementary Figures 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f36080e898856202202ea1946d09740
https://doi.org/10.1158/1535-7163.22523851
https://doi.org/10.1158/1535-7163.22523851
Autor:
Yiguan Zhang, Yongxin Tang, Ben Chen, Frederick Valeriote, Subhash Gautam, Xiaohua Gao, Jiajiu Shaw
Publikováno v:
American Journal of Biomedical Sciences. :228-236
UTL-5g is a small-molecule TNF-α modulator that is anti-inflammatory in a carrageenan-induced edema animal model and chemoprotective against anticancer drug-induced side effects. Recently, it was shown that UTL-5g is a prodrug and its active metabol
Autor:
Yiguan, Zhang, Frederick, Valeriote, Kenneth, Swartz, Ben, Chen, Mark T, Hamann, Douglas L, Rodenburg, James D, McChesney, Jiajiu, Shaw
Publikováno v:
Natural product communications. 10(8)
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious pathogen that is resistant to current antibiotic therapy. Thus, there is an urgent need for novel antimicrobial agents that can effectively combat these new strains of drug-resistant "su
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity
Autor:
Subhash C. Sinha, Halina Pietraszkiewicz, Matthew Edelstein, Frederick Valeriote, Zheng Zheng Huang, Zhiyong Chen, Eiko Nakamaru-Ogiso
Publikováno v:
Journal of medicinal chemistry. 51(22)
A systematic analysis using ten synthetic asimicin stereoisomers revealed that the stereochemistry of the bis-tetrahydrofuran core, including the tetrahydrofuran rings and the adjacent hydroxy functions, had significant effect on its cytotoxicity. Ou
Publikováno v:
The Journal of organic chemistry. 68(5)
A synthesis of four Annonaceous acetogenins, asiminocin, asimicin, asimin, and bullanin, by a modular approach from seven fundamental subunits, A-G, is described. The approach employs a central core aldehyde segment, C, to which are appended an aliph
Publikováno v:
The Journal of organic chemistry. 68(5)
A synthesis of the bistetrahydrofuran Annonaceous acetogenins 30(S)-hydroxybullatacin, uvarigrandin A, and 5(R)-uvarigrandin A through application of a previously disclosed four-component modular approach is described in which extended core segments
Autor:
Balanehru, Subramanian, Alexander, Nakeff, Joseph, Media, Mark, Wentland, Frederick, Valeriote
Publikováno v:
Journal of experimental therapeuticsoncology. 2(5)
The cellular paradigm presented here defines the cellular action profile of new anticancer agents that complements our discovery and development paradigm. The main elements of this profile include a concentration clonogenicity response relationship o
Publikováno v:
American Journal of Biomedical Sciences; Apr2012, Vol. 4 Issue 2, p123-131, 9p
Publikováno v:
Biochimica et biophysica acta. 221(2)
Structural studies were performed on hepatic tyrosine aminotransferase isolated from rats injected with triamcinolone. The enzyme, treated with guanidine · HCl, was partially dissociated into a species of mol. wt. 32 000. The number of peptides sepa