Esophageal Hypervigilance and Visceral Anxiety Are Contributors to Symptom Severity Among Patients Evaluated With High-Resolution Esophageal Manometry

Autor: Peter J. Kahrilas, François Mion, Laurie Keefer, Michael D. Crowell, Dustin A. Carlson, John E. Pandolfino, Jacqueline Prescott, Joseph Triggs, Farhan Quader, Dario Biasutto, C. Prakash Gyawali, Frederick T.J. Lin, Marcelo F. Vela, Tiffany H. Taft, Karthik Ravi, Sabine Roman

Publikováno v: Am J Gastroenterol

OBJECTIVES Symptoms are inconsistently associated with esophageal motor findings on high-resolution manometry (HRM). We aimed to evaluate predictors of dysphagia severity, including esophageal hypervigilance and visceral anxiety, among patients evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c117c151db06a8c41e3b68c758b1f75
https://doi.org/10.14309/ajg.0000000000000536

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Autor: Maria Carolina Borges, M. Geoffrey Hayes, Ke Hao, Carol A. Wang, Marjo-Riitta Järvelin, Niina Pitkänen, Ilkka Kalliala, Mariona Bustamante, Olli T. Raitakari, Bridget A. Knight, Robin N Beaumont, Matthew T. Weirauch, Line Skotte, Matthias Wielscher, Mark I. McCarthy, Klaus Bønnelykke, Vincent W. V. Jaddoe, Elina Hyppönen, Ole Mors, Tarunveer S. Ahluwalia, Thomas Werge, Frank Geller, Jonathan P. Bradfield, Vivek Appadurai, Kristin Skogstrand, Merete Nordentoft, Suzanne Vogelezang, Preben Bo Mortensen, Xueping Liu, Daniel Miller, Hakon Hakonarson, João Fadista, Pål R. Njølstad, Leah C. Kottyan, Wesley K. Thompson, Bruce Bedell, Katja Pahkala, Stefan Johansson, Dorte Helenius, Louis J. Muglia, Janine F. Felix, Rachel M. Freathy, Heather A. Boyd, Bjarke Feenstra, Ge Zhang, Anubha Mahajan, Alfonso Buil, Bo Jacobsson, Martine Vrijheid, Frederick T.J. Lin, William L. Lowe, Mads Melbye, Ron Nudel, Denise M. Scholtens, Julius Juodakis, Shouneng Peng, Christine Power, Andrew J. Schork, Jeffrey C. Murray, David M. Hougaard, Craig E. Pennell, Øyvind Helgeland, Struan F.A. Grant, Kelli K. Ryckman, Mary L. Marazita, Xiaoting Chen, Jonas Bacelis, Anders D. Børglum, Debbie A Lawlor, Hans Bisgaard, Robert M. Rossi, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Rebecca K. Vinding

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Miller, D E, Chen, X, Weirauch, M T, Mortensen, P B, Børglum, A D, Nordentoft, M, Mors, O, Hao, K, Ryckman, K K, Hougaard, D M, Kottyan, L C, Pennell, C E, Lyytikainen, L-P, Bønnelykke, K, Vrijheid, M, Felix, J F, Lowe, W L, Grant, S F A, Hyppönen, E, Jacobsson, B, Jarvelin, M-R, Muglia, L J, Murray, J C, Freathy, R M, Werge, T M, Melbye, M, Buil, A & Feenstra, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, no. 1, 3927 . https://doi.org/10.1038/s41467-019-11881-8
Nature communications, vol 10, iss 1
Nature Communications
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Miller, D E, Chen, X, Weirauch, M T, Mortensen, P B, Børglum, A D, Nordentoft, M, Mors, O, Hao, K, Ryckman, K K, Hougaard, D M, Kottyan, L C, Pennell, C E, Lyytikainen, L-P, Bønnelykke, K, Vrijheid, M, Felix, J F, Lowe, W L, Grant, S F A, Hyppönen, E, Jacobsson, B, Jarvelin, M-R, Muglia, L J, Murray, J C, Freathy, R M, Werge, T M, Melbye, M, Buil, A & Feenstra, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, 3927 (2019) . https://doi.org/10.1038/s41467-019-11881-8
Nature Communications, 10:3927. Nature Publishing Group
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Mortensen, P B, Børglum, A D, Mors, O & Jacobsson, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, no. 1, 3927, pp. 1-13 . https://doi.org/10.1038/s41467-019-11881-8

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdce669ac365fdce646e8f4934aa82cb
https://doaj.org/article/0663e700e52e44dd96778ff7a9670192

Multi-ancestry Genome- and Phenome-wide Association Studies of Diverticular Disease in Electronic Health Records with Natural Language Processing enriched phenotype algorithm

Autor: Omri Gottesman, Frederick T.J. Lin, James G. Linneman, Mariza de Andrade, Luke V. Rasmussen, Rex L. Chisholm, Joshua C. Denny, Annapoorani Veerappan, Gerard Tromp, Laura J. Rasmussen-Torvik, Kenneth M. Borthwick, Andrew Cagan, Peggy L. Peissig, Jyotishman Pathak, M. Geoffrey Hayes, Ning Shang Shang, Erwin P. Bottinger, William K. Thompson, Jennifer A. Pacheco, Stephen B. Ellis, Andrew J. Gawron, Maureen E. Smith, Yoonjung Yoonie Joo, David Carrell, Abel N. Kho

Background and aimsDiverticular disease is among the most prevalent conditions encountered by gastroenterologists, affecting ∼50% of Americans before the age of 60. Our aim was to identify genetic risk variants and clinical phenotypes associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e08c4c98f1159a3e13441ba2cf0f8b08
https://doi.org/10.1101/2020.06.08.138735

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis

Autor: Frederick T.J. Lin, Ryan Sisk, Richard S. Legro, Matthew Dapas, Margrit Urbanek, Girish N. Nadkarni, Andrea Dunaif, M. Geoffrey Hayes

Publikováno v: PLoS Medicine
PLoS Medicine, Vol 17, Iss 6, p e1003132 (2020)

Background Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic criteria applied. These diagnostic criteria are based on expert opinion and have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d5806d2a8e79aa43f227cf2077f446
https://doi.org/10.1371/journal.pmed.1003132

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

Autor: Bjarke Feenstra, Preben Bo Mortensen, Hakon Hakonarson, Carol A. Wang, Alfonso Buil, Ole Mors, Ron Nudel, Vincent W. V. Jaddoe, Matthew T. Weirauch, Ilkka Kalliala, Katja Pahkala, Elina Hyppönen, Frederick T.J. Lin, Jonathan P. Bradfield, Maria Carolina Borges, Frank Geller, Christine Power, Craig E. Pennell, Matthias Wielscher, Janine F. Felix, Denise M. Scholtens, Ge Zhang, Marjo-Riitta Järvelin, Andrew J. Schork, Wesley K. Thompson, David M. Hougaard, Daniel Miller, Line Skotte, Rachel M. Freathy, Mads Melbye, Shouneng Peng, Heather A. Boyd, Suzanne Vogelezang, João Fadista, Pål R. Njølstad, Bo Jacobsson, Merete Nordentoft, Xueping Liu, Leo-Pekka Lyytikäinen, Robert M. Rossi, Fernando Rivadeneira, Rebecca K. Vinding, Mary L. Marazita, M. Geoffrey Hayes, Ke Hao, Mariona Bustamante, Dorte Helenius, Tarunveer S. Ahluwalia, Jeffrey C. Murray, Kristin Skogstrand, Vivek Appadurai, Øyvind Helgeland, Bridget A. Knight, Robin N Beaumont, Thomas Werge, Klaus Bønnelykke, Mark I. McCarthy, Struan F.A. Grant, William L. Lowe, Hans Bisgaard, Bruce Bedell, Louis J. Muglia, Martine Vrijheid, Leah C. Kottyan, Stefan Johansson, Anders D. Børglum, Niina Pitkänen, Kelli K. Ryckman, Olli T. Raitakari, Xiaoting Chen, Jonas Bacelis, Debbie A Lawlor, Anubha Mahajan, Julius Juodakis

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. We conducted a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee2cbddc11f6783ea16f3cdeddfd756