Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Frederick S. Varn"'
Autor:
Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F. Bruns, Khaja Syed, James A. Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S. Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A. Care, Luisa Cutillo, David R. Westhead, Susan C. Short, Michael D. Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G. W. Verhaak, Lucy F. Stead
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing da
Externí odkaz:
https://doaj.org/article/190c474079fc465a883fccd59c89b7b7
Autor:
Yona Kim, Frederick S. Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G. W. Verhaak, Sun Ha Paek
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of 12–16 months. The complexity of GBM treatment mainly lies in the inter- and intr
Externí odkaz:
https://doaj.org/article/f9d5a299ebbd44bc8b99d034e1b64aff
Autor:
Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel Verhaak, Anand Shankar, Santhoshi N. Krishnan, Frederick S. Varn, Víctor A. Arrieta, Pravesh Gupta, Sherise D. Ferguson, Jason T. Huse, Gregory N. Fuller, James P. Long, Daniel E. Winkowski, Ben A. Freiberg, Charles David James, Leonidas C. Platanias, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
BACKGROUND Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.METHODS En bloc resections of gliomas (n = 10) and lung metastases (n = 10) w
Externí odkaz:
https://doaj.org/article/ee2104f14ae1491f89501b1b618cfbda
Autor:
Matthias Gromeier, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E. Herndon, Frederick S. Varn, Roel G. Verhaak, Junfei Zhao, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, Frances McSherry, Andrea M. Muscat, Eric S. Lipp, Smita K. Nair, Mustafa Khasraw, Katherine B. Peters, Dina Randazzo, John H. Sampson, Roger E. McLendon, Darell D. Bigner, David M. Ashley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Recurrent glioblastomas (rGBM) have dismal outcomes, but long-term survival has been observed in subsets of patients after immunotherapy. Here the authors report a positive association between low tumor mutation burden, inflammatory gene signatures,
Externí odkaz:
https://doaj.org/article/9b4f7304b8f54613b5f0b6626698e589
Autor:
Yanding Zhao, Robert Carter, Sivaraman Natarajan, Frederick S. Varn, Duane A. Compton, Charles Gawad, Chao Cheng, Kristina M. Godek
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal c
Externí odkaz:
https://doaj.org/article/97ce881b83ec43f092d71709a1835645
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular mechanisms that underli
Externí odkaz:
https://doaj.org/article/7f87b7e060444d77a614679b0738ced6
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Immune checkpoint inhibitors have shown great potential in treating solid tumors, inducing durable remission and prolonged survival time in responders. Despite their promise, a large fraction of patients remains unresponsive to these treatments highl
Externí odkaz:
https://doaj.org/article/438e03523e7841cbb8d8022767fcc659
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Tumour samples are heterogeneous and are comprised of multiple cell types in addition to cancer cells. Here, the authors devised a method to estimate the relative levels of haematopoietic cells in breast cancer samples and demonstrate that this corre
Externí odkaz:
https://doaj.org/article/12d103b3d080434da061c3d03435a48e
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
Non-small cell lung cancer is one of the leading causes of cancer-related death in the world. Lung adenocarcinoma, the most common type of non-small cell lung cancer, has been well characterized as having a dense lymphocytic infiltrate, suggesting th
Externí odkaz:
https://doaj.org/article/e6e3f5e8676d41aeaf0c57677238a50b
Autor:
Al Charest, Vassiliki A. Boussiotis, Roel G.W. Verhaak, Steven P. Gygi, Hemant Varma, Joon Yoon, Vicky A. Appleman, Frederick S. Varn, Christopher M. Rose, Shruti Rawal, Piyan Zhang, Tuoye Xu, Rinku Pal, Konstantinos Aliazis, Rushil Shah, Alan T. Yeo
supplementary figures & legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70022129900a397dd403b1e4e220bf3a
https://doi.org/10.1158/2326-6066.22736977.v1
https://doi.org/10.1158/2326-6066.22736977.v1