Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frederick Ray Kinder"'
Autor:
Frederick Ray Kinder, Robert Daeffler, Ernst Kuesters, Weichun Chen, Emil Schmid, Run-Ming Wang, Daniel Niederer, Kapa Prasad, Remo Gamboni, Karl Schaer, Ian Paterson, Isabelle Lyothier, Adnan Osmani, Stuart J. Mickel, Kurt Königsberger, Gordon J. Florence, Loeser Eric M, Oljan Repic, Timothy Michael Ramsey
Publikováno v:
Organic Process Research & Development. 8:122-130
The finale of the large-scale preparation of 60 g of the highly complex marine natural product, (+)-discodermolide (1), using a hybridized Novartis−Smith−Paterson synthetic route is presented. This contribution, which is the concluding part of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38fae1061260aceaea14fa8b5fb7d4a9
https://doi.org/10.1021/op034134j
https://doi.org/10.1021/op034134j
Autor:
Remo Gamboni, Stephen Chen, Jagoe Christopher Turchik, Gottfried Sedelmeier, Yansong Lu, Timothy Michael Ramsey, and Run-Ming Wang, Alfred Hirni, Robert Daeffler, Frederick Ray Kinder, Joseph Mckenna, Guido Koch, Andrew Bach, Hong-Yong Kim, and Karl Schaer, Oljan Repic, Mahavir Prashad, Wen-Chung Shieh, Stuart J. Mickel, Dominique Grimler, Friedrich Schuerch, Adnan Osmani, Liladhar Murlidhar Waykole, Yugang Liu, Bin Hu, Larry Rogers, Daniel Niederer, Weichun Chen, Apurva Chaudhary
Publikováno v:
Organic Process Research & Development. 8:101-106
Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) of (+)-discodermolide from common precursor 3 are described. Improved procedures for each step of both fragments were developed by minimizing or eliminating the formation of byproducts that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d48749d744ab1158633990c308bc966
https://doi.org/10.1021/op0341317
https://doi.org/10.1021/op0341317
Autor:
Stuart J. Mickel, Mauricio Loo, Frederick Ray Kinder, Remo Gamboni, Stephen Chen, Manuela Seeger-Weibel, Weichun Chen, Jagoe Christopher Turchik, Adnan Osmani, Robert Daeffler, Brigitte Berod, Daniel Niederer, Song Xue, Run-Ming Wang, Oljan Repic, Klaus Schreiner, Xu David, Wen-Chung Shieh, Liladhar Murlidhar Waykole, Kapa Prasad, Gottfried Sedelmeier, Karl Schaer
Publikováno v:
Organic Process Research & Development. 8:92-100
The synthetic strategy for producing multigram quantities of (+)-discodermolide (1) using a hybridized Novartis−Smith−Paterson synthetic route via common precursor 3 is described. In the first part of this five-part series, we present a multikilo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6724fb15e2f2f3403c7b2f36e2a0a7
https://doi.org/10.1021/op034130e
https://doi.org/10.1021/op034130e
Autor:
Wen-Chung Shieh, Robert Daeffler, Run-Ming Wang, Remo Gamboni, Song Xue, Friedrich Schuerch, Loeser Eric M, Gordon Florence and, Ian Paterson, Guang-Pei Chen, Daniel Niederer, Adnan Osmani, Frederick Ray Kinder, Kapa Prasad, Joseph Mckenna, Jacques Cercus, Klaus Schreiner, Gottfried Sedelmeier, Manuela Seger, Olivier Loiseleur, Kurt Königsberger, Timothy Michael Ramsey, Larry Rogers, Andrew Bach, Oljan Repic, Weichun Chen, Noela Reel, Dominique Bixel, Peng Geng, and Liladhar Waykole, and Karl Schaer, Stuart J. Mickel, Hans Stettler, George T. Lee
Publikováno v:
Organic Process Research & Development. 8:113-121
Coupling of C9-14 (4) and C15-21 (5a) fragments to produce the cis-trisubstituted olefin was achieved using Suzuki-type coupling conditions employed by Marshall (5a/tert-BuLi/B-OMe-9-BBN added to 4/Cs2CO3/Pd(dppf)2). The terminal (Z)-diene moiety was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636e79cabb468b439dd0390f88424064
https://doi.org/10.1021/op034133r
https://doi.org/10.1021/op034133r
Autor:
Patrick Schindler, Anthony A. Morollo, Richard William Versace, Hans Voshol, Penny E. Phillips, Hyun Kyu Song, Frederick Ray Kinder, Kenneth W. Bair, James A. DeCaprio, Sunkyu Kim, Jeanette Marjorie Wood, Sonya Zabludoff, Michael J. Eck, Harry Towbin, Dieter Mueller, Jan van Oostrum
Publikováno v:
Journal of Biological Chemistry. 278:52964-52971
LAF389 is a synthetic analogue of bengamides, a class of marine natural products that produce inhibitory effects on tumor growth in vitro and in vivo. A proteomics-based approach has been used to identify signaling pathways affected by bengamides. LA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc2177d41b19ffd4f676f4359e5325d9
https://doi.org/10.1074/jbc.m309039200
https://doi.org/10.1074/jbc.m309039200
Autor:
Frederick Ray Kinder
Publikováno v:
Organic Preparations and Procedures International. 34:559-583
(2002). SYNTHETIC APPROACHES TOWARD THE BENGAMIDE FAMILY OF ANTITUMOR MARINE NATURAL PRODUCTS. A REVIEW. Organic Preparations and Procedures International: Vol. 34, No. 6, pp. 559-583.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4977c7f64e3e46d3d6b2ae0d009a42d7
https://doi.org/10.1080/00304940209355783
https://doi.org/10.1080/00304940209355783
Autor:
John Bontempo, Jagoe Christopher Turchik, Yin Mou, Ania M. Czuchta, Penny E. Phillips, Kenneth W. Bair, Frederick Ray Kinder, Long D. Tran, Sonya Zabludoff, Steven Chen, Run-Ming Wang, David Cesarz, Raphael Nemzek, Richard William Versace, Susan Weltchek, Phillip Crews
Publikováno v:
Journal of Medicinal Chemistry. 44:3692-3699
Bengamide B, a novel sponge-derived marine natural product with broad spectrum antitumor activity, was not suitable for further preclinical development because of its difficult synthesis and very poor water solubility. Bengamide B produced a 31% T/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17234048bcbfe0dae8659e5596f5dcde
https://doi.org/10.1021/jm010188c
https://doi.org/10.1021/jm010188c
Autor:
Yansong J. Lu, John Bontempo, Frederick Ray Kinder, Sonya Zabludoff, H. Rao Marepalli, Liladhar Murlidhar Waykole, Run-Ming Wang, and David D. Xu, Sompong Wattanasin, Richard William Versace, Kenneth W. Bair, Penny E. Phillips, Long D. Tran, Didier Roche, Green Michael A
Publikováno v:
The Journal of Organic Chemistry. 66:2118-2122
Total syntheses of the cytotoxic marine natural products bengamides B and E are described. Both bengamides are prepared via amide coupling of a protected polyhydroxylated lactone intermediate 9 with a suitably substituted aminocaprolactam intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fc9ec261da2078cc8e3f74191a7410
https://doi.org/10.1021/jo0017133
https://doi.org/10.1021/jo0017133
Publikováno v:
Synthetic Communications. 28:2541-2548
Isodehydroilludin M was synthesized from carbonyl ylid 1,3-dipolar cycloaddition product that was further elaborated with an unusual PCC-mediated double oxidation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0535778fee766df96ba2800ddbe25cf
https://doi.org/10.1080/00397919808004305
https://doi.org/10.1080/00397919808004305
Autor:
Frederick Ray Kinder
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34e93d9fbcb0ce7ee1a7f20fef9fbcb
https://doi.org/10.1002/chin.200316247
https://doi.org/10.1002/chin.200316247