Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Frederick R Cross"'
Autor:
Kresti Pecani, Kristi Lieberman, Natsumi Tajima-Shirasaki, Masayuki Onishi, Frederick R Cross
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1009997 (2022)
In yeast and animals, cyclin B binds and activates the cyclin-dependent kinase ('CDK') CDK1 to drive entry into mitosis. We show that CYCB1, the sole cyclin B in Chlamydomonas, activates the plant-specific CDKB1 rather than the CDK1 ortholog CDKA1, c
Externí odkaz:
https://doaj.org/article/c75d2ff9b60c4498a146bc4c46ea589a
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009471 (2021)
DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs. Cyclin Dependent Kinase (CDK) regulates both assembly and firing of the pre-replicat
Externí odkaz:
https://doaj.org/article/11ee82d39acd4b1090d3ba6ed737a175
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159166 (2016)
B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during and after mitotic exit, APC/C is dependent on Cdh1. Cd
Externí odkaz:
https://doaj.org/article/85e78fb813594e3aa741f1aabd61a00d
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-13 (2009)
Abstract Cyclin‐dependent kinase (Cdk) both promotes mitotic entry (spindle assembly and anaphase) and inhibits mitotic exit (spindle disassembly and cytokinesis), leading to an elegant quantitative hypothesis that a single cyclin oscillation can f
Externí odkaz:
https://doaj.org/article/fe8f0ff209bd471b84f8579ae027c1a0
Autor:
Nicolas E Buchler, Frederick R Cross
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-7 (2009)
Abstract Ultrasensitive responses are crucial for cellular regulation. Protein sequestration, where an active protein is bound in an inactive complex by an inhibitor, can potentially generate ultrasensitivity. Here, in a synthetic genetic circuit in
Externí odkaz:
https://doaj.org/article/b83a252addc04995938a881cb49d6807
Autor:
Catherine Oikonomou, Frederick R Cross
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20788 (2011)
Diverse mitotic events can be triggered in the correct order and time by a single cyclin-CDK. A single regulator could confer order and timing on multiple events if later events require higher cyclin-CDK than earlier events, so that gradually rising
Externí odkaz:
https://doaj.org/article/0a5d2dae9682486da9cc6778df47b41a
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000284 (2010)
Budding yeast cells irreversibly commit to a new division cycle at a regulatory transition called Start. This essential decision-making step involves the activation of the SBF/MBF transcription factors. SBF/MBF promote expression of the G1 cyclins en
Externí odkaz:
https://doaj.org/article/fec0d3b7d6f247138e084fe2257e878b
Autor:
Stefano Di Talia, Hongyin Wang, Jan M Skotheim, Adam P Rosebrock, Bruce Futcher, Frederick R Cross
Publikováno v:
PLoS Biology, Vol 7, Iss 10, p e1000221 (2009)
In budding yeast, asymmetric cell division yields a larger mother and a smaller daughter cell, which transcribe different genes due to the daughter-specific transcription factors Ace2 and Ash1. Cell size control at the Start checkpoint has long been
Externí odkaz:
https://doaj.org/article/904841478b8d41ecbbdc243417e29610
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1468 (2008)
BACKGROUND:Imaging single cells with fluorescent markers over multiple cell cycles is a powerful tool for unraveling the mechanism and dynamics of the cell cycle. Over the past ten years, microfluidic techniques in cell biology have emerged that allo
Externí odkaz:
https://doaj.org/article/cc857e63d78a44c2af7fa53001e5474a
Autor:
Moshe Kafri, Weronika Patena, Lance Martin, Lianyong Wang, Gillian Gomer, Arthur K Sirkejyan, Audrey Goh, Alexandra T. Wilson, Sophia E Gavrilenko, Michal Breker, Asael Roichman, Claire D. McWhite, Joshua D. Rabinowitz, Frederick R Cross, Martin Wühr, Martin C. Jonikas
SUMMARYPhotosynthesis is central to food production and the Earth’s biogeochemistry, yet the molecular basis for its regulation remains poorly understood. Here, using high-throughput genetics in the model eukaryotic algaChlamydomonas reinhardtii, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e78cc922425ab981fb0a866929793d
https://doi.org/10.1101/2022.11.12.515357
https://doi.org/10.1101/2022.11.12.515357
