Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Frederick P. Schwarz"'
Publikováno v:
Biology, Vol 12, Iss 10, p 1277 (2023)
Bacteriophage endolysins degrade the bacterial peptidoglycan and are considered enzymatic alternatives to small-molecule antibiotics. In particular, the multimeric streptococcal endolysin PlyC has appealing antibacterial properties. However, a compre
Externí odkaz:
https://doaj.org/article/2cbd8116aed54495b8fe11f3f24006a5
Bacteriophage endolysins degrade the bacterial peptidoglycan and are considered enzymatic alternatives to small molecule antibiotics. In particular, the multimeric streptococcal endolysin PlyC has appealing antibacterial properties. However, a compre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031df307dcba7b491f7436108ddfbd4b
https://doi.org/10.1101/2022.01.06.475266
https://doi.org/10.1101/2022.01.06.475266
Autor:
Duilio Cascio, Ganesaratnam K. Balendiran, Frederick P. Schwarz, Richard Cuckovich, Michael R. Sawaya, Gomathinayagam Ponniah, Malkhey Verma
Publikováno v:
Journal of Biological Chemistry. 286:6336-6344
Diabetic tissues are enriched in an "activated" form of human aldose reductase (hAR), a NADPH-dependent oxidoreductase involved in sugar metabolism. Activated hAR has reduced sensitivity to potential anti-diabetes drugs. The C298S mutant of hAR repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacbc272253c305886baed0d6c40eb7c
https://doi.org/10.1074/jbc.m110.154195
https://doi.org/10.1074/jbc.m110.154195
Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase
Autor:
Frederick P. Schwarz, Niya A. Todorova
Publikováno v:
Archives of Biochemistry and Biophysics. 480:122-131
The thermodynamics of the drug-inhibitors acyclovir, ganciclovir, and 9-benzylguanine binding to human purine nucleoside phosphorylase (hsPNP) were determined from isothermal titration calorimetry as a function of the substrate phosphate ion (Pi) con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0253bf6c73e5da11f8746e4882e30d
https://doi.org/10.1016/j.abb.2008.10.008
https://doi.org/10.1016/j.abb.2008.10.008
Autor:
Barry A. Fields, Xavier Ysern, Frederick P. Schwarz, Ana Cauerhff, William Dall'Acqua, Roy A. Mariuzza, Fernando A. Goldbaum, Emilio L. Malchiodi, Talapady N. Bhat, Bradford C. Braden, Roberto J. Poljak
Publikováno v:
Annals of the New York Academy of Sciences. 764:315-327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53559346e657d42770de38b7681085e7
https://doi.org/10.1111/j.1749-6632.1995.tb55843.x
https://doi.org/10.1111/j.1749-6632.1995.tb55843.x
Publikováno v:
Pure and Applied Chemistry. 80:2025-2040
Isothermal titration calorimetry (ITC) is widely used to determine the thermodynamics of biological interactions including protein-protein, small molecule-protein, protein-DNA, small molecule-DNA, and antigen-antibody interactions. An ITC measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635a081ec450f1954d4bb23abf5e2da5
https://doi.org/10.1351/pac200880092025
https://doi.org/10.1351/pac200880092025
Autor:
Eugene Melamud, Zvi Kelman, Rajesh Kasiviswanathan, Frederick P. Schwarz, Mimi Han, Nozomi Sakakibara
Publikováno v:
Nucleic Acids Research
Minichromosome maintenance (MCM) helicases are the presumptive replicative helicases, thought to separate the two strands of chromosomal DNA during replication. In archaea, the catalytic activity resides within the C-terminal region of the MCM protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f0165c53011fdea34685c9f86f42b7
http://europepmc.org/articles/PMC2275104
http://europepmc.org/articles/PMC2275104
Autor:
Niya A. Todorova, Frederick P. Schwarz
Publikováno v:
The Journal of Chemical Thermodynamics. 39:1038-1048
The thermodynamic parameters, Δ B G ∘ , Δ B H ∘ , Δ B S ∘ , and Δ B C p , of the drugs flurbiprofen (FLP), nabumetone (NAB), and naproxen (NPX) binding to β-cyclodextrin (βCD) and to γ-cyclodextrin (γCD) in 0.10 M sodium phosphate buffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f6d2f97ca5ef2a66abbd45a79fa9ac
https://doi.org/10.1016/j.jct.2006.12.019
https://doi.org/10.1016/j.jct.2006.12.019
Publikováno v:
Biopolymers. 81:235-248
A comprehensive study of the thermal stabilization of defatted human albumin monomer by n-alkyl fatty acid anions (FAAs), formate through n-decanoate, was carried out by differential scanning calorimetry (DSC). The concentration of each ligand afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a0bdd36c9a000ced506d873fc4fda
https://doi.org/10.1002/bip.20406
https://doi.org/10.1002/bip.20406
Publikováno v:
Archives of Biochemistry and Biophysics. 438:162-173
The energetics of LRP binding to a 104 bp lac promoter determined from ITC measurements were compared to the energetics of binding to a shorter 40 bp DNA duplex with the 21 bp promoter binding site sequence. The promoter binding affinity of 2.47 +/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc8b1ee49161d0f9ad9fb571ff0aba7
https://doi.org/10.1016/j.abb.2005.04.017
https://doi.org/10.1016/j.abb.2005.04.017