Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Frederick Meece"'
Publikováno v:
Organic Letters. 20:5886-5888
The synthesis of densely functionalized trisubstituted and tetrasubstituted furans via a novel Ru(II)-catalyzed intramolecular cyclization of vinyl diazoesters is reported. The synthetic utility of these furans is further demonstrated through a simpl
Autor:
John C. Widen, Jordan W. Baur, Jacob T. Edwards, Dennis A. Brown, Hannah M. Skopec, Daniel A. Harki, Aaron M. Kempema, Tenley J. Brown, Frederick Meece
Helenalin is a pseudoguaianolide natural product that targets Cys38 within the DNA binding domain of NF-κB transcription factor p65 (RelA). Helenalin contains two Michael acceptors that covalently modify cysteines: a α-methylene-γ-butyrolactone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75ca3cfe819b88fa263e2655fbad5c5
https://europepmc.org/articles/PMC5894512/
https://europepmc.org/articles/PMC5894512/
Autor:
Timothy E. Andrews, Susan K. Rathe, Joseph K. Hexum, Aaron M. Kempema, John C. Widen, Klara E. Noble, Dan Wang, Frederick Meece, Zohar Sachs, Daniel A. Harki, David A. Largaespada
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4737-4745
Parthenolide (PTL) is a sesquiterpene lactone natural product with anti-proliferative activity to cancer cells. Selective eradication of leukemic stem cells (LSCs) over healthy hematopoietic stem cells (HSCs) by PTL has been demonstrated in previous
Autor:
Birgitt Schneider, Klaus Nickisch, Hareesh B. Nair, Wyrwa Ralf, Walter Elger, Gulzar Ahmed, Frederick Meece
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
A series of estradiol-17-β esters of N-(p-sulfomylbenzamide)-amino acids were prepared and evaluated for systemic and hepatic estrogenic activity after oral administration in ovariectomized rats. The alkyl substitution at nitrogen of amino acids suc
Autor:
Daniel A. Harki, Frederick Meece, Aaron M. Kempema, Jacob T. Edwards, John C. Widen, Hannah M. Skopec, Dennis A. Brown, Jordan W. Baur, Tenley J. Brown
Publikováno v:
ChemMedChem. 13:288-288