Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Frederick M. Stanley"'
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138097 (2015)
Plasminogen activator inhibitor type 1 (PAI-1) is a multifunctional protein that has important roles in inflammation and wound healing. Its aberrant regulation may contribute to many disease processes such as heart disease. The PAI-1 promoter is resp
Externí odkaz:
https://doaj.org/article/90648e96498f45e38ca5e1ab54016c9e
Autor:
Frederick M. Stanley, Anthony I. Vulin
Publikováno v:
Journal of Biological Chemistry. 279:25172-25178
Oxidative stress is one of the characteristics of diabetes and is thought to be responsible for many of the pathophysiological changes caused by the disease. We previously identified an insulin response element in the promoter of plasminogen activato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da65c6199907901ae47fb9b98af8a7fd
https://doi.org/10.1074/jbc.m403184200
https://doi.org/10.1074/jbc.m403184200
Autor:
Frederick M. Stanley, Anthony I. Vulin
Publikováno v:
Journal of Biological Chemistry. 277:20169-20176
Plasminogen activator inhibitor-1 (PAI-1) is an important regulator of fibrinolysis by its inhibition of both tissue-type and urokinase plasminogen activators. PAI-1 levels are elevated in type II diabetes and this elevation correlates with macro- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974c7205f46a2404d797a26d582fc3b4
https://doi.org/10.1074/jbc.m112073200
https://doi.org/10.1074/jbc.m112073200
Publikováno v:
Molecular and Cellular Endocrinology. 186:7-16
Insulin treatment increased prolactin gene expression in GH4 cells, a rat pituitary tumor cell line, through the endogenous insulin receptor. However, insulin regulation of transfected plasmids required the expression of cotransfected insulin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545a2b4918da0783432534c4cbe76cec
https://doi.org/10.1016/s0303-7207(01)00674-8
https://doi.org/10.1016/s0303-7207(01)00674-8
Autor:
Kirsten K. Jacob, Frederick M. Stanley
Publikováno v:
Endocrinology. 140:4542-4550
The sequence −101/−92 of the PRL promoter has been shown to be essential for both basal and hormone-increased PRL gene transcription. It is important to identify transcription factors that bind to this sequence if we are to understand the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c294e18e679c4058891477ca52f3d5
https://doi.org/10.1210/endo.140.10.7076
https://doi.org/10.1210/endo.140.10.7076
Publikováno v:
Molecular and Cellular Endocrinology. 152:137-145
Epidermal growth factor (EGF) increases prolactin gene expression in GH4 cells, but the promoter element(s) required for this response has not been clearly defined. We identified a bipartite element −96/−87, −76/−67 in the rat proximal promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebc61cc79690faf811996c0e3e1f9e4
https://doi.org/10.1016/s0303-7207(99)00043-x
https://doi.org/10.1016/s0303-7207(99)00043-x
Publikováno v:
Journal of Biological Chemistry. 273:4800-4809
A physiologically relevant response to insulin, stimulation of prolactin promoter activity in GH4 pituitary cells, was used as an assay to study the specificity of protein-tyrosine phosphatase function. Receptor-like protein-tyrosine phosphatase alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab4246f9a15a569c024b2a51709bcc9
https://doi.org/10.1074/jbc.273.8.4800
https://doi.org/10.1074/jbc.273.8.4800
Publikováno v:
Molecular and cellular endocrinology. 382(1)
Insulin increases prolactin gene expression in GH4 cells through phosphorylation of Elk-1 (Jacob and Stanley, 2001). We preformed a reverse two-hybrid screen using Elk-1-B42 as bait to identify proteins from GH4 cells that might serve as co-activator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42372596b8aca32877f7ba3e3729d2c9
https://pubmed.ncbi.nlm.nih.gov/24075908
https://pubmed.ncbi.nlm.nih.gov/24075908
Publikováno v:
Journal of Biological Chemistry. 271:10425-10428
The insulin-response element from the prolactin gene is identical to the Ets-binding site, and dominant-negative Ets protein inhibits insulin-increased prolactin gene expression. Immunoblotting identified the Ets-related transcription factor GABP in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f46fe0bed2ea47e0754a169145a268
https://doi.org/10.1074/jbc.271.18.10425
https://doi.org/10.1074/jbc.271.18.10425
Autor:
Frederick M. Stanley, Kirsten K. Jacob
Publikováno v:
Molecular and Cellular Endocrinology. 109:175-181
Insulin and cAMP stimulate prolactin gene transcription and prolactin-CAT expression in rat pituitary tumor GH cells. Expression of prolactin-CAT construct, pPrl(−173/+75)CAT, is stimulated 10- to 30-fold by either insulin or cAMP Addition of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dedd905f1d23c34a1ec80890590e50
https://doi.org/10.1016/0303-7207(95)03500-7
https://doi.org/10.1016/0303-7207(95)03500-7