Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Frederick Luk"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 25-32 (2016)
The confinement of multiple myeloma (MM) to the bone marrow microenvironment requires an invasive bone marrow biopsy to monitor the malignant compartment. The existing clinical tools used to determine treatment response and tumor relapse are limited
Externí odkaz:
https://doaj.org/article/3d61214c6dde4504b2b92224cbc437d5
Autor:
Deep Pokharel, Matthew P. Padula, Jamie F. Lu, Jessica L. Tacchi, Frederick Luk, Steven P. Djordjevic, Mary Bebawy
Publikováno v:
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-10 (2014)
Cancer multidrug resistance (MDR) occurs when cancer cells evade the cytotoxic actions of chemotherapeutics through the active efflux of drugs from within the cells. Our group have previously demonstrated that multidrug-resistant breast cancer cells
Externí odkaz:
https://doaj.org/article/a24743d45d1d45a2862ab3acd80acbe8
Autor:
Mary Bebawy, Ariane Roseblade, Frederick Luk, Tristan Rawling, Alison Ung, Georges E. R. Grau
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 16, Iss 2 (2013)
Intercellular communication is essential to maintain vital physiological activities and to regulate the organism’s phenotype. There are a number of ways in which cells communicate with one another. This can occur via autocrine signaling, endocrine
Externí odkaz:
https://doaj.org/article/af455319f48848e7a6877a52bb1af377
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61515 (2013)
Microparticles (MPs) play a vital role in cell communication by facilitating the horizontal transfer of cargo between cells. Recently, we described a novel "non-genetic" mechanism for the acquisition of multidrug resistance (MDR) in cancer cells by i
Externí odkaz:
https://doaj.org/article/8cbb90dedac54f9c83af544e8c26f35d
Publikováno v:
International Journal of Oncology. 49:33-50
Multiple myeloma (MM) is a mature B cell neoplasm that results in multi-organ failure. The median age of onset, diverse clinical manifestations, heterogeneous survival rate, clonal evolution, intrinsic and acquired drug resistance have impact on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83162882be8340a801f3f53ce120469
https://doi.org/10.3892/ijo.2016.3516
https://doi.org/10.3892/ijo.2016.3516
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 25-32 (2016)
The confinement of multiple myeloma (MM) to the bone marrow microenvironment requires an invasive bone marrow biopsy to monitor the malignant compartment. The existing clinical tools used to determine treatment response and tumor relapse are limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8435a2be292c04f468affbfd88d3eda
Publikováno v:
European Journal of Pharmacology. 721:116-125
Expanding on our previous findings demonstrating that microparticles (MPs) spread cancer multidrug resistance, we now show that MPs sequester drugs, reducing the free drug concentration available to cells. MPs were isolated from drug-sensitive and dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87445f4b5866a18d82eee7b74ad49e12
https://doi.org/10.1016/j.ejphar.2013.09.044
https://doi.org/10.1016/j.ejphar.2013.09.044
Publikováno v:
Pharmacological Research. 76:77-83
Multidrug resistance (MDR) is a major impediment to the overall success of chemotherapy in clinical oncology. MDR has been primarily attributed by the ATP-dependent transmembrane proteins, P-glycoprotein (P-gp, ABCB1) and Multidrug Resistance-Associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fd81dd6e565d6a808bddb9b3a1a38a
https://doi.org/10.1016/j.phrs.2013.07.009
https://doi.org/10.1016/j.phrs.2013.07.009
Publikováno v:
Cancer Investigation. 29:521-532
Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eda087cecb0fad5645f46a4acbe6e4a
https://doi.org/10.3109/07357907.2011.606252
https://doi.org/10.3109/07357907.2011.606252
Publikováno v:
Journal of biomedical nanotechnology. 11(6)
Copyright © 2015 American Scientific Publishers. All rights reserved. Although curcumin is effective in killing cancer cells, its low water solubility and inadequate bioavailability remain major limitations to its therapeutic application. Formulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708c0c087c5bf01e933381ac4cea68a0
https://pubmed.ncbi.nlm.nih.gov/26353597
https://pubmed.ncbi.nlm.nih.gov/26353597