Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Frederick Lo"'
Autor:
Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activi
Externí odkaz:
https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d669558
Autor:
Minhua Qiu, Bin Zhou, Frederick Lo, Steven Cook, Jason Chyba, Doug Quackenbush, Jason Matzen, Zhizhong Li, Puiying Annie Mak, Kaisheng Chen, Yingyao Zhou
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Image-based high throughput (HT) screening provides a rich source of information on dynamic cellular response to external perturbations. The large quantity of data generated necessitates computer-aided quality control (QC) methodo
Externí odkaz:
https://doaj.org/article/23f6918ff2e14f61ab120eae3ff4ee2e
Autor:
Sarah E Vidal Yucha, Doug Quackenbush, Tiffany Chu, Frederick Lo, Jeffrey J Sutherland, Guray Kuzu, Christopher Roberts, Fabio Luna, S Whitney Barnes, John Walker, Pia Kuss
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277937 (2022)
The importance of human cell-based in vitro tools to drug development that are robust, accurate, and predictive cannot be understated. There has been significant effort in recent years to develop such platforms, with increased interest in 3D models t
Externí odkaz:
https://doaj.org/article/609099d49d8d43539c3c59ac1f5da6fc
Autor:
Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/810912beabae49e5ae801ee19704df74
Autor:
Yingyao Zhou, Frederick Lo, Steven C. Cook, Zhizhong Li, Bin Zhou, Kaisheng Chen, Jason Chyba, Puiying Annie Mak, Doug Quackenbush, Minhua Qiu, Jason T. Matzen
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)
BMC Bioinformatics
BMC Bioinformatics
Background Image-based high throughput (HT) screening provides a rich source of information on dynamic cellular response to external perturbations. The large quantity of data generated necessitates computer-aided quality control (QC) methodologies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b719885a47b0f5e47317e25ccb2dd91
http://link.springer.com/article/10.1186/s12859-020-03603-5
http://link.springer.com/article/10.1186/s12859-020-03603-5
Autor:
Emily Rowell, Jeremy To, Lilin Li, Frederick Lo, Shane R. Horman, Doug Quackenbush, Connor Reed
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Communications Biology
Communications Biology
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. However, exploratory assays involving immune components ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ce229509fd6fc8417a68fdb83e1d9
https://doi.org/10.1038/s42003-021-02569-1
https://doi.org/10.1038/s42003-021-02569-1
Publikováno v:
Materials Research, Vol 27 (2024)
Metal forming processes present many changes in the strain path necessary to obtain the dimensions and shape of a metal part. The loading mode, the amount of prestrain, the initial state of a material and its respective substructural arrangements aff
Externí odkaz:
https://doaj.org/article/c02d894699b04c5bb1b49cb15a19d9a4
Autor:
Emily Rowell, Frederick Lo, Shane R. Horman, Jeremy To, Doug Quackenbush, Connor Reed, Lilin Li
Publikováno v:
Communications Biology. 4
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. However, exploratory assays involving immune components ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580878d6c8b203dc4beb36f14e94d6df
https://doi.org/10.1038/s42003-020-01565-1
https://doi.org/10.1038/s42003-020-01565-1
Publikováno v:
Future Medicinal Chemistry. 7:513-525
Increasingly, organotypic cellular platforms are being recognized as useful tools in drug discovery. This review offers an industry-centric perspective on the benefits of emerging complex cell models over conventional 2D systems, as well as the chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7526d8b3e7ef38ecee64435e765c8af
https://doi.org/10.4155/fmc.14.163
https://doi.org/10.4155/fmc.14.163
Autor:
Surbhi Sidana, Lauren C. Peres, Hamza Hashmi, Hitomi Hosoya, Christopher Ferreri, Jack Khouri, Danai Dima, Shebli Atrash, Peter Voorhees, Gary Simmons, Douglas W. Sborov, Nilesh Kalariya, Vanna Hovanky, Sushma Bharadwaj, David Miklos, Charlotte Wagner, Mehmet H. Kocoglu, Gurbakhash Kaur, James A. Davis, Shonali Midha, Murali Janakiram, Ciara Freeman, Melissa Alsina, Frederick Locke, Rebecca Gonzalez, Yi Lin, Joseph McGuirk, Aimaz Afrough, Leyla Shune, Krina K. Patel, Doris K. Hansen
Publikováno v:
Haematologica, Vol 109, Iss 3 (2023)
We evaluated patients with relapsed multiple myeloma with renal impairment (RI) treated with standard of care idecabtagene vicleucel (ide-cel), as outcomes with chimeric antigen receptor (CAR) T-cell therapy are unknown in this population. RI was def
Externí odkaz:
https://doaj.org/article/e20fe1cc56fe454eae49245689ffabf6