Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Frederick K. Kamanu"'
Autor:
Julian Späth, Julian Matschinske, Frederick K. Kamanu, Sabina A. Murphy, Olga Zolotareva, Mohammad Bakhtiari, Elliott M. Antman, Joseph Loscalzo, Alissa Brauneck, Louisa Schmalhorst, Gabriele Buchholtz, Jan Baumbach
Publikováno v:
PLOS Digital Health, Vol 1, Iss 9 (2022)
Clinical time-to-event studies are dependent on large sample sizes, often not available at a single institution. However, this is countered by the fact that, particularly in the medical field, individual institutions are often legally unable to share
Externí odkaz:
https://doaj.org/article/3848810023e345f496a17ece06cc1fce
Autor:
Nicholas A Marston, Amanda C Garfinkel, Frederick K Kamanu, Giorgio M Melloni, Carolina Roselli, Petr Jarolim, David D Berg, Deepak L Bhatt, Marc P Bonaca, Christopher P Cannon, Robert P Giugliano, Michelle L O’Donoghue, Itamar Raz, Benjamin M Scirica, Eugene Braunwald, David A Morrow, Patrick T Ellinor, Steven A Lubitz, Marc S Sabatine, Christian T Ruff
Publikováno v:
Eur Heart J
Aims Interest in targeted screening programmes for atrial fibrillation (AF) has increased, yet the role of genetics in identifying patients at highest risk of developing AF is unclear. Methods and results A total of 36,662 subjects without prior AF w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be6641d2ac7ddd34565c574a515d50
https://europepmc.org/articles/PMC10310983/
https://europepmc.org/articles/PMC10310983/
Autor:
Benjamin M. Scirica, Christian T. Ruff, Robert P. Giugliano, Christopher P. Cannon, Peter S. Sever, Eugene Braunwald, Robert F. Storey, Frederick K. Kamanu, Marc S. Sabatine, Yared Gurmu, Steven A. Lubitz, Christopher D. Anderson, Elliott M. Antman, Parth N Patel, Marc P. Bonaca, Philippe Gabriel Steg, Patrick T. Ellinor, Michelle L. O'Donoghue, Lu-Chen Weng, Anthony C Keech, Itamar Raz, Ofri Mosenzon, Marc Cohen, Deepak L. Bhatt, Francesco Nordio, Nicholas A Marston, Carolina Roselli, Giorgio M. Melloni
Publikováno v:
Circulation
Background: Genome-wide association studies have identified single-nucleotide polymorphisms that are associated with an increased risk of stroke. We sought to determine whether a genetic risk score (GRS) could identify subjects at higher risk for isc
Autor:
Ofri Mosenzon, Marc P. Bonaca, Ilaria Cavallari, Anthony C Keech, Itamar Raz, Marc Cohen, Philippe Gabriel Steg, Nicholas A Marston, Yared Gurmu, Marc S. Sabatine, Robert F. Storey, Carolina Roselli, Giorgio E. M. Melloni, Benjamin M. Scirica, Deepak L. Bhatt, Patrick T. Ellinor, Christina J.-Y. Lee, Frederick K. Kamanu, Christian T. Ruff, Robert P. Giugliano, Eugene Braunwald, Steven A. Lubitz
Publikováno v:
Circulation-Genomic and precision medicine, 14(1):e003006, 82-87. LIPPINCOTT WILLIAMS & WILKINS
Circ Genom Precis Med
Circ Genom Precis Med
Background: Venous thromboembolism (VTE) is a major cause of cardiovascular morbidity and mortality and has a known genetic contribution. We tested the performance of a genetic risk score for its ability to predict VTE in 3 cohorts of patients with c
Autor:
Marc S. Sabatine, Huei Wang, Terje R. Pedersen, Frederick K. Kamanu, Anthony C Keech, Yared Gurmu, Francesco Nordio, Nicholas A Marston, Steven A. Lubitz, Carolina Roselli, Christian T. Ruff, Robert P. Giugliano, Patrick T. Ellinor, Peter S. Sever, Armando Lira Pineda
Publikováno v:
Circulation
Circulation, 141(8), 616-623. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 141(8), 616-623. LIPPINCOTT WILLIAMS & WILKINS
Background: The ability of a genetic risk score to predict risk in established cardiovascular disease and identify individuals who derive greater benefit from PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition has not been established.
Autor:
Svati H. Shah, Olle Melander, Neneh Sallah, Quinn S. Wells, Jerome I. Rotter, Faye Zhao, Charlotte Andersson, Guðmundur Thorgeirsson, Ghazaleh Fatemifar, Alex S. F. Doney, Michael E. Dunn, David E. Lanfear, Ian Ford, Eric Boersma, Sonia Shah, Christopher Newton-Cheh, Douglas L. Mann, Niek Verweij, Carolina Roselli, Laura M. Yerges-Armstrong, Jian Yang, Christian Torp-Pedersen, Veikko Salomaa, Mary L. Biggs, Alaa Shalaby, Christoph Nowak, Stefan Gross, Patrick T. Ellinor, Mari Liis Tammesoo, Diane T. Smelser, Peter M. Visscher, Hans L. Hillege, Ruth C. Lovering, Honghuang Lin, Colin N. A. Palmer, Louis Philippe Lemieux Perreault, Jeffrey Brandimarto, Uwe Völker, Perttu Salo, Andrea Koekemoer, Rebecca Gutmann, Åsa K. Hedman, Nilesh J. Samani, Heming Xing, Faiez Zannad, Jaison Jacob, Harry Hemingway, Michael R. Brown, Franco Giulianini, Anubha Mahajan, Xing Chen, Alexander Niessner, Peter Almgren, Daniel I. Swerdlow, Gunnar Engström, Lars Lind, Tõnu Esko, Tomasz Czuba, Anna Helgadottir, Harvey D. White, David J. Stott, Johan Ärnlöv, Lars Køber, Chim C. Lang, Krishna G. Aragam, Kent D. Taylor, Anders Mälarstig, Frederick K. Kamanu, Kenneth B. Margulies, Michelle L. O'Donoghue, Andrew D. Morris, Sahar Ghasemi, J. Wouter Jukema, Jessica van Setten, Abbas Dehghan, Guillaume Paré, Luca A. Lotta, Giorgio E. M. Melloni, Albert Henry, Bruce M. Psaty, Paul M. Ridker, David J. Carey, Marie-Pierre Dubé, John S. Gottdiener, Xiaosong Wang, Per H. Svensson, Xu Chen, Patrik K. E. Magnusson, Claudia Langenberg, Alexander Teumer, Vilmantas Giedraitis, Simon de Denus, Michael W. Nagle, Marcus Dörr, Thomas P. Cappola, André G. Uitterlinden, Michael Morley, Eliana Portilla-Fernandez, J. Gustav Smith, Abirami Veluchamy, Peter Weeke, Ify R. Mordi, Unnur Thorsteinsdottir, Naveed Sattar, Folkert W. Asselbergs, Daniel I. Chasman, Daníel F. Guðbjartsson, Jonathan H. Chung, Marcus E. Kleber, Raul Weiss, Christopher P. Nelson, Spiros Denaxas, Bing Yu, Simon P. R. Romaine, Nicholas A Marston, Anjali T. Owens, Cecilia M. Lindgren, John J.V. McMurray, Joshua D. Backman, Michael V. Holmes, Stella Trompet, Hilma Holm, Kerri L. Wiggins, Jian'an Luan, Stephan B. Felix, Yifan Yang, Jemma B. Wilk, Maryam Kavousi, Markus Perola, Christian T. Ruff, Jean-Claude Tardif, G Sveinbjörnsson, Samuel C. Dudley, Nicholas J. Wareham, Teemu J. Niiranen, Andrew P. Morris, Danny Tuckwell, Maris Teder-Laving, R. Thomas Lumbers, James P. Cook, Géraldine Asselin, William A. Chutkow, Winfried März, Steven A. Lubitz, John G.F. Cleland, Bill Kraus, Ramachandran S. Vasan, Christopher M. Haggerty, Olympe Chazara, Chris Finan, Heather L. Bloom, Hans-Peter Brunner-La Rocca, Francoise Fougerousse, Kenneth Rice, Craig L. Hyde, Graciela E. Delgado, Mark Chaffin, Marc S. Sabatine, Alanna C. Morrison, Kay-Tee Khaw, Kari Stefansson, Felix Vaura, Barry London, Isabella Kardys, Aroon D. Hingorani, Hongsheng Gui, Steen Stender, René Fouodjio, Mohsen Ghanbari, Pim van der Harst, Nicholas L. Smith, Karoline Kuchenbaecker, Adriaan A. Voors, Benoit Tyl
Publikováno v:
ESC Heart Failure
ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩
2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure. WILEY PERIODICALS, INC
ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC
ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology
ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩
Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
Esc heart failure, 8(6). John Wiley & Sons Inc.
Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩
2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure. WILEY PERIODICALS, INC
ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC
ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology
ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩
Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
Esc heart failure, 8(6). John Wiley & Sons Inc.
Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.Methods and results The consortium currently includes 51 studies from 11 countries, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc41b40a62755853d7042fbc1dfd58a0
https://hal.univ-lorraine.fr/hal-03357134
https://hal.univ-lorraine.fr/hal-03357134
Autor:
Fiona R. Saunders, Scott Wilson, Benjamin H. Mullin, Claudiu V. Giuraniuc, Tim D. Spector, Frederick K. Kamanu, Douglas P. Kiel, Claes Ohlsson, Frances M K Williams, Deborah Jenkins, Denis Baird, Rebecca J. Barr, Nancy E Lane, Benjamin G. Faber, J. Brent Richards, Eric S. Orwoll, Elin Grundberg, Daniel Richard, Lavinia Paternoster, David M. Evans, Thomas J. Beck, Ulrika Pettersson-Kymmer, Jonathan H Tobias, Jennifer S. Gregory, David Karasik, Steven R. Cummings, Daniel S. Evans, Richard M. Aspden, Terence D. Capellini, Debbie A Lawlor
Publikováno v:
Journal of Bone and Mineral Research
Baird, D A, Evans, D S, Kamanu, F K, Gregory, J S, Saunders, F R, Giuraniuc, C V, Barr, R J, Aspden, R M, Jenkins, D, Kiel, D P, Orwoll, E S, Cummings, S R, Lane, N E, Mullin, B H, Williams, F M K, Richards, J B, Wilson, S G, Spector, T D, Faber, B G, Lawlor, D A, Grundberg, E, Ohlsson, C, Pettersson-Kymmer, U, Capellini, T D, Richard, D, Beck, T J, Evans, D M, Paternoster, L, Karasik, D & Tobias, J H 2018, ' Identification of Novel Loci Associated With Hip Shape : A Meta-Analysis of Genomewide Association Studies ', Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.3605
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 34, iss 2
Baird, DA; Evans, DS; Kamanu, FK; Gregory, JS; Saunders, FR; Giuraniuc, CV; et al.(2018). Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies. Journal of Bone and Mineral Research. doi: 10.1002/jbmr.3605. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2tj6x8b6
Baird, D A, Evans, D S, Kamanu, F K, Gregory, J S, Saunders, F R, Giuraniuc, C V, Barr, R J, Aspden, R M, Jenkins, D, Kiel, D P, Orwoll, E S, Cummings, S R, Lane, N E, Mullin, B H, Williams, F M K, Richards, J B, Wilson, S G, Spector, T D, Faber, B G, Lawlor, D A, Grundberg, E, Ohlsson, C, Pettersson-Kymmer, U, Capellini, T D, Richard, D, Beck, T J, Evans, D M, Paternoster, L, Karasik, D & Tobias, J H 2018, ' Identification of Novel Loci Associated With Hip Shape : A Meta-Analysis of Genomewide Association Studies ', Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.3605
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 34, iss 2
Baird, DA; Evans, DS; Kamanu, FK; Gregory, JS; Saunders, FR; Giuraniuc, CV; et al.(2018). Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies. Journal of Bone and Mineral Research. doi: 10.1002/jbmr.3605. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2tj6x8b6
© 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc. We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is though
Autor:
Krishna G, Aragam, Tao, Jiang, Anuj, Goel, Stavroula, Kanoni, Brooke N, Wolford, Deepak S, Atri, Elle M, Weeks, Minxian, Wang, George, Hindy, Wei, Zhou, Christopher, Grace, Carolina, Roselli, Nicholas A, Marston, Frederick K, Kamanu, Ida, Surakka, Loreto Muñoz, Venegas, Paul, Sherliker, Satoshi, Koyama, Kazuyoshi, Ishigaki, Bjørn O, Åsvold, Michael R, Brown, Ben, Brumpton, Paul S, de Vries, Olga, Giannakopoulou, Panagiota, Giardoglou, Daniel F, Gudbjartsson, Ulrich, Güldener, Syed M Ijlal, Haider, Anna, Helgadottir, Maysson, Ibrahim, Adnan, Kastrati, Thorsten, Kessler, Theodosios, Kyriakou, Tomasz, Konopka, Ling, Li, Lijiang, Ma, Thomas, Meitinger, Sören, Mucha, Matthias, Munz, Federico, Murgia, Jonas B, Nielsen, Markus M, Nöthen, Shichao, Pang, Tobias, Reinberger, Gavin, Schnitzler, Damian, Smedley, Gudmar, Thorleifsson, Moritz, von Scheidt, Jacob C, Ulirsch, David O, Arnar, Noël P, Burtt, Maria C, Costanzo, Jason, Flannick, Kaoru, Ito, Dong-Keun, Jang, Yoichiro, Kamatani, Amit V, Khera, Issei, Komuro, Iftikhar J, Kullo, Luca A, Lotta, Christopher P, Nelson, Robert, Roberts, Gudmundur, Thorgeirsson, Unnur, Thorsteinsdottir, Thomas R, Webb, Aris, Baras, Johan L M, Björkegren, Eric, Boerwinkle, George, Dedoussis, Hilma, Holm, Kristian, Hveem, Olle, Melander, Alanna C, Morrison, Marju, Orho-Melander, Loukianos S, Rallidis, Arno, Ruusalepp, Marc S, Sabatine, Kari, Stefansson, Pierre, Zalloua, Patrick T, Ellinor, Martin, Farrall, John, Danesh, Christian T, Ruff, Hilary K, Finucane, Jemma C, Hopewell, Robert, Clarke, Rajat M, Gupta, Jeanette, Erdmann, Nilesh J, Samani, Heribert, Schunkert, Hugh, Watkins, Cristen J, Willer, Panos, Deloukas, Sekar, Kathiresan, Adam S, Butterworth
Publikováno v:
Nat. Genet. 54, 1803-1815 (2022)
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases amo
Autor:
Peter S. Sever, Christian T. Ruff, Marc Cohen, Michelle L. O'Donoghue, Robert P. Giugliano, Christopher D. Anderson, Marc P. Bonaca, Deepak L. Bhatt, Eugene Braunwald, Benjamin M. Scirica, Patrick T. Ellinor, Frederick K. Kamanu, Nicholas A Marston, Philippe Gabriel Steg, Robert F. Storey, Marc S. Sabatine, Ofri Mosenzon, Christopher P. Cannon, Parth N Patel, Steven A. Lubitz, Lu-Chen Weng, Anthony C Keech, Itamar Raz
Publikováno v:
Circulation. 142
Introduction: Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that are associated with an increased risk of stroke. We sought to determine whether a genetic risk score (GRS) could identify subjects at hig
Autor:
Nicholas A Marston, Seung Hoan Choi, Marc S. Sabatine, Anthony C Keech, Christian T. Ruff, Huei Wang, Patrick T. Ellinor, Frederick K. Kamanu, Robert P. Giugliano, Giorgio E. M. Melloni, Steven A. Lubitz, James P. Pirruccello, Peter S. Sever, Armando Lira Pineda, Anthony A. Philippakis
Publikováno v:
Circulation. 142
Introduction: Patients with loss of function (LoF) mutations of the LDL receptor gene (LDLR) have lifelong elevations in LDL-C. We investigated their risk of cardiovascular (CV) events compared with patients with intact LDLR function. Methods: We per