Výsledky vyhledávání - "Frederick J. Troendle"

Synthesis, computational docking study, and biological evaluation of a library of heterocyclic curcuminoids with remarkable antitumor activity

Autor: Asher Chanan-Khan, William J. Greves, Sharoon Akhtar, Kenneth K. Laali, Angela T. Zwarycz, Sebastian J. Correa Smits, Frederick J. Troendle, Aneel Paulus, Alak Manna, Manabu Nukaya, Gabriela L. Borosky, Gregory D. Kennedy

In a continuing search for curcuminoid (CUR) compounds with antitumor activity, a novel series of heterocyclic CUR–BF2 adducts and CUR compounds based on indole, benzothiophene, and benzofuran along with their aryl pyrazoles were synthesized. Compu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420260215a66c0772352516b32ed2bb0
Wiley Online Library

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Front Cover: Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity (ChemMedChem 18/2018)

Autor: William J. Greves, Kenneth K. Laali, Asher Chanan-Khan, Gregory D. Kennedy, Alak Manna, Sharoon Akhtar, Sebastian J. Correa Smits, Gabriela L. Borosky, Aneel Paulus, Angela T. Zwarycz, Frederick J. Troendle, Manabu Nukaya

Publikováno v: ChemMedChem. 13:1853-1853

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::657f4781beadec3c70ee81cb369ef854
https://doi.org/10.1002/cmdc.201800584

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Detection of pharmaceutical compounds in tissue by matrix-assisted laser desorption/ionization and laser desorption/chemical ionization tandem mass spectrometry with a quadrupole ion trap

Autor: Frederick J. Troendle, Christopher D. Reddick, Richard A. Yost

Publikováno v: Journal of the American Society for Mass Spectrometry. 10:1315-1321

A novel quadrupole ion trap mass spectrometer laser microprobe instrument with an external ionization source was constructed and used to investigate the matrix-assisted laser desorption/ionization (MALDI) detection of pharmaceutical compounds in inta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6ab2e023f8f5724e70d6288dd1804e
https://doi.org/10.1016/s1044-0305(99)00103-8

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NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to Citiolone

Autor: Frederick J. Troendle, Kunisi S. Venkatasubban, Robert Rothchildb

Publikováno v: Spectroscopy Letters. 30:435-450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8edd4fb40c3bab5a96e3e0db75ba169
https://doi.org/10.1080/00387019708006670

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Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

Autor: Melody Stallings-Mann, Frederick J. Troendle, Andrew Courtenay, Michael W. DeLucia, Wing C. Lee, Chad A. Dickey, Dennis W. Dickson, Christopher B. Eckman

Publikováno v: The FASEB Journal. 19:1549-1551

Globoid cell leukodystrophy (GLD) or Krabbe disease is a devastating, degenerative neurological disorder caused by mutations in the galactosylceramidase (GALC) gene that severely affect enzyme activity. Currently, treatment options for this disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eb123549ada5d53bad5a469befda1e
https://doi.org/10.1096/fj.05-3826fje

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NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to the Analgesic, Famprofazone: 'Anomalous Shifts'

Autor: Kunisi S. Venkatasubban, Patricia Sakon Williams, Robert Rothchild, Frederick J. Troendle

Publikováno v: Spectroscopy Letters. 29:1229-1251

The 200 MHz 1H NMR spectra of the analgesic, famprofazone, 1, have been studied in CDCl3 solution at ambient temperatures with the achiral lanthanide shift reagent (LSR) tris (6, 6, 7, 7, 8, 8, 8-heptaf luoro-2, 2-dimethyl-3, 5-octanedionato) europiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2c35a5e102f78d43ab5d196314a1714
https://doi.org/10.1080/00387019608007118

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Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy

Autor: Yuen K. Tsoi, Frederick J. Troendle, Christopher B. Eckman, Zeshan Ahmed, Chad A. Dicky, Wing C. Lee, Dennis W. Dickson, Michael W. DeLucia

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(10)

Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a devastating, degenerative neurological disorder. It is inherited as an autosomal recessive trait caused by loss-of-function mutations in the galactocerebrosidase (GALC) gene. Previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c53176378b7694f8fb64368a36ca2d
https://pubmed.ncbi.nlm.nih.gov/17403939

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Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

Autor: Frederick J. Troendle, Murad A. Kahn, Abdul H. Fauq, Hong D. Xiao, Christopher B. Eckman, Stephanie K. Adams, Elizabeth A. Eckman, Kenneth E. Bernstein, Becky A. Stodola

Publikováno v: The Journal of biological chemistry. 281(41)

The deposition of beta-amyloid in the brain is a pathological hallmark of Alzheimer disease (AD). Normally, the accumulation of beta-amyloid is prevented in part by the activities of several degradative enzymes, including the endothelin-converting en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4a994a288ef224182dd9f89d4c607e
https://pubmed.ncbi.nlm.nih.gov/16912050

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