Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Frederick J. Seidl"'
Publikováno v:
Molecules, Vol 26, Iss 13, p 3829 (2021)
We show that 1M aqueous HCl/THF or NaBH4/DMF allows for demercurative ring-opening of cyclic organomercurial synthons into secondary silanol products bearing terminal alkenes. We had previously demonstrated that primary allylic silanols are readily t
Externí odkaz:
https://doaj.org/article/09db03848a814237949510fba3045cfa
Autor:
Frederick J. Seidl, Noah Z. Burns
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1361-1365 (2016)
The scope of a recently reported method for the catalytic enantioselective bromochlorination of allylic alcohols is expanded to include a specific homoallylic alcohol. Critical factors for optimization of this reaction are highlighted. The utility of
Externí odkaz:
https://doaj.org/article/a0838d2da08f42618abdb170591dd492
Publikováno v:
Tetrahedron. 137:133390
Publikováno v:
J Org Chem
We present the first examples of tethered silanoxyiodination reactions of allylic alcohols. The products are usefulsilanediol organoiodide synthons and are formed with high regioselectivity and diastereocontrol. The reaction is scalable greater than
Autor:
Ranjeet A. Dhokale, Joel T. Mague, Shyam Sathyamoorthi, Someshwar Nagamalla, Frederick J. Seidl
Publikováno v:
Org Chem Front
We present the first examples of rearrangement reactions of allylic silanol substrates into linear ketone and 5-membered cyclic silanediol organomercurial products. Both reactions are mediated by Hg(OTf)(2) but differ in the use of base, solvent, and
Autor:
Frederick J. Seidl, Ranjeet A. Dhokale, Someshwar Nagamalla, Shyam Sathyamoorthi, Joel T. Mague
We present the first examples of rearrangement reactions of allylic silanol substrates into linear ketone and 5-membered cyclic silanediol organomercurial products. Both reactions are mediated by Hg(OTf)2 but differ in the use of base, solvent, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c67472390c1789f9dc4dffa944cbade
https://doi.org/10.33774/chemrxiv-2021-mw89q
https://doi.org/10.33774/chemrxiv-2021-mw89q
Publikováno v:
Molecules
Volume 26
Issue 13
Molecules, Vol 26, Iss 3829, p 3829 (2021)
Volume 26
Issue 13
Molecules, Vol 26, Iss 3829, p 3829 (2021)
We show that 1M aqueous HCl/THF or NaBH4/DMF allows for demercurative ring-opening of cyclic organomercurial synthons into secondary silanol products bearing terminal alkenes. We had previously demonstrated that primary allylic silanols are readily t
Autor:
Tzu-Tang Wei, Mark Chandy, Masataka Nishiga, Angela Zhang, Kaavya Krishna Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne Marie Justesen, Ian Y. Chen, Hung-Ta Wo, Saereh Khanamiri, Johnson Y. Yang, Frederick J. Seidl, Noah Z. Burns, Chun Liu, Nazish Sayed, Jiun-Jie Shie, Chih-Fan Yeh, Kai-Chien Yang, Edward Lau, Kara L. Lynch, Manuel Rivas, Brian K. Kobilka, Joseph C. Wu
Publikováno v:
Cell, vol 185, iss 10
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, binds to cannabinoid receptor
We show that 1M aq. HCl/THF or NaBH4/DMF allows for demercurative ring-opening of cyclic organomercurial synthons into secondary silanol products bearing terminal alkenes. We had previously demonstrated that primary allylic silanols are readily trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121d2b1b687b431f79249c6073011f8b
https://doi.org/10.26434/chemrxiv.13679083.v1
https://doi.org/10.26434/chemrxiv.13679083.v1
Publikováno v:
Journal of the American Chemical Society. 139:13562-13569
Herein we report that under mild solvolytic conditions, enantioenriched bromochlorides can be ionized, stereospecifically cyclized to an array of complex bromocyclic scaffolds, or intermolecularly trapped by exogenous nucleophiles. Mechanistic invest