Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Frederick J. Monsma"'
Autor:
Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Aleksandra Gladych-Macioszek, Agnieszka Klupczynska-Gabryszak, Teagan Polotaye, Michael Greenberg, Douglas Kung, Emily Hyde, Sarah Alshehri, Tonja Pavlovic, William Sullivan, Szymon Plewa, Helin Vakifahmetoglu-Norberg, Frederick J. Monsma, Patricia A. J. Muller, Jan Matysiak, Mikołaj Piotr Zaborowski, Analisa DiFeo, Erik Norberg, Laura A. Martin, Marcin Iwanicki
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1816 (2024)
Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovar
Externí odkaz:
https://doaj.org/article/a222c33366d1413daf27361dcf8f4bc2
Autor:
Lauren Schiff, Bianca Migliori, Ye Chen, Deidre Carter, Caitlyn Bonilla, Jenna Hall, Minjie Fan, Edmund Tam, Sara Ahadi, Brodie Fischbacher, Anton Geraschenko, Christopher J. Hunter, Subhashini Venugopalan, Sean DesMarteau, Arunachalam Narayanaswamy, Selwyn Jacob, Zan Armstrong, Peter Ferrarotto, Brian Williams, Geoff Buckley-Herd, Jon Hazard, Jordan Goldberg, Marc Coram, Reid Otto, Edward A. Baltz, Laura Andres-Martin, Orion Pritchard, Alyssa Duren-Lubanski, Ameya Daigavane, Kathryn Reggio, NYSCF Global Stem Cell Array® Team, Phillip C. Nelson, Michael Frumkin, Susan L. Solomon, Lauren Bauer, Raeka S. Aiyar, Elizabeth Schwarzbach, Scott A. Noggle, Frederick J. Monsma, Daniel Paull, Marc Berndl, Samuel J. Yang, Bjarki Johannesson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Externí odkaz:
https://doaj.org/article/9d8265097577462f83aa83bf77ad2240
Autor:
Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Agnieszka Klupczynska-Gabryszak, Douglas Kung, Teagan Polotaye, Emily Hyde, Tonja Pavlovic, Sarah Alshehri, William Sullivan, Szymon Plewa, Frederick J Monsma, Jan Matysiak, Mikolaj Zaborowski, Analisa Difeo, Laura A. Martin, Erik Norberg, Marcin Iwanicki
Publikováno v:
bioRxiv
Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d242cb144ceeb857a6f58f2b4420813
https://europepmc.org/articles/PMC10002676/
https://europepmc.org/articles/PMC10002676/
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Autor:
Lauren, Schiff, Bianca, Migliori, Ye, Chen, Deidre, Carter, Caitlyn, Bonilla, Jenna, Hall, Minjie, Fan, Edmund, Tam, Sara, Ahadi, Brodie, Fischbacher, Anton, Geraschenko, Christopher J, Hunter, Subhashini, Venugopalan, Sean, DesMarteau, Arunachalam, Narayanaswamy, Selwyn, Jacob, Zan, Armstrong, Peter, Ferrarotto, Brian, Williams, Geoff, Buckley-Herd, Jon, Hazard, Jordan, Goldberg, Marc, Coram, Reid, Otto, Edward A, Baltz, Laura, Andres-Martin, Orion, Pritchard, Alyssa, Duren-Lubanski, Ameya, Daigavane, Kathryn, Reggio, Phillip C, Nelson, Michael, Frumkin, Susan L, Solomon, Lauren, Bauer, Raeka S, Aiyar, Elizabeth, Schwarzbach, Scott A, Noggle, Frederick J, Monsma, Daniel, Paull, Marc, Berndl, Samuel J, Yang, Bjarki, Johannesson
Publikováno v:
Nature communications. 13(1)
Drug discovery for diseases such as Parkinson’s disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and d
Autor:
Minjie Fan, Samuel Yang, Orion Pritchard, Sean DesMarteau, Zan Armstrong, Selwyn Jacob, Marc Coram, Peter Ferrarotto, Edward A. Baltz, Lauren Schiff, Edmund Tam, Alyssa Duren-Lubanski, Ameya Daigavane, Geoff Buckley-Herd, Brian Williams, Elizabeth Schwarzbach, Raeka S. Aiyar, Jordan Goldberg, Jenna Hall, Daniel Paull, Deidre Carter, Marc Berndl, Scott Noggle, Reid Otto, Jon Hazard, Frederick J. Monsma, Lauren Bauer, Caitlyn Bonilla, Brodie Fischbacher, Bianca Migliori, Ye Chen, Sara Ahadi, Bjarki Johannesson, Subhashini Venugopalan, Christopher J. Hunter, Arunachalam Narayanaswamy, Anton Geraschenko, Kathryn Reggio, Laura Andres-Martin
Drug discovery for diseases such as Parkinson’s disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0736c9ee7dda2c99486a56f923ee84dc
https://doi.org/10.1101/2020.11.13.380576
https://doi.org/10.1101/2020.11.13.380576
Autor:
Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola
Publikováno v:
Journal of medicinal chemistry. 63(5)
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Publikováno v:
Analytical chemistry. 88(3)
The process of bringing a drug to market involves many steps, including the preclinical stage, where various properties of the drug candidate molecule are determined. These properties, which include drug absorption, distribution, metabolism, and excr
Autor:
Frederick J. Monsma, Rumin Zhang
Publikováno v:
Expert Opinion on Drug Discovery. 5:1023-1029
Binding kinetics (BK), an often overlooked key aspect of the broader concept of drug mechanism of action (MOA), is increasingly recognized as a springboard from pharmacokinetics (PK) to pharmacodynamics, and as a critical differentiator and predictor
Autor:
Asra Malikzay, Lynn Miesel, Dayna L. Daubaras, Rumin Zhang, Cynthia Kravec, Frederick J. Monsma, Charles A. Lunn, William A. LaMarr, Richard F. Hart, Can C. Ozbal, Todd A. Black, Erik F. Langsdorf
Publikováno v:
SLAS Discovery. 15:52-61
A high-throughput mass spectrometry assay to measure the catalytic activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, LpxC, is described. This reaction is essential in the biosynthesis of lipopolysaccharide (LPS) of gram-nega