Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Frederick J. Bex"'
Autor:
Weiguang Zhao, Raymond Unwalla, Frederick J. Bex, Richard J. Murrills, John A. Robinson, Nippa Alon, Usha Varadarajan, Paul J. Yaworsky, Adam M. Gilbert, Valerie E. Coleburn, Virginia Gironda, Diane B. Hauze, Matthew Kirisits, Michael C. Sharp, Paula Green, Yao-Bin Liu, Yogendra P. Kharode, Girija Krishnamurthy, Matthew Gregory Bursavich, Bheem M. Bhat, Michael Cain, Sabrina Lombardi, Jeanne J. Matteo, Sally Selim, Ho-Sun Lam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:366-370
A series of (hetero)arylpyrimidines agonists of the Wnt-beta-catenin cellular messaging system have been prepared. These compounds show activity in U2OS cells transfected with Wnt-3a, TCF-luciferase, Dkk-1 and tk-Renilla. Selected compounds show mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf51cfbc58bde75044a12e24b5e0086f
https://doi.org/10.1016/j.bmcl.2009.10.093
https://doi.org/10.1016/j.bmcl.2009.10.093
Autor:
Diane B. Hauze, Michael C. Sharp, Bheem M. Bhat, Paula Green, Colleen Milligan, Daniel M. Green, Jennifer Pirrello, Peter V.N. Bodine, Ronald L. Magolda, Adam M. Gilbert, Matthew D. Vera, Yogendra P. Kharode, Valerie E. Coleburn, Luciana De Araujo Felix, Mattew G. Bursavich, Nipa Alon, Jeanne J. Matteo, Jay Wrobel, Frederick J. Bex, Jeffrey C. Pelletier, Susan Lockhead, Joseph T. Lundquist, Richard J. Murrills, Ray Unwalla, Paul J. Yaworsky, Sally Selim, John F. Mehlmann, Ho-Sun Lam
Publikováno v:
Journal of Medicinal Chemistry. 52:6962-6965
A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt beta-catenin cellular messaging system. Hit-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eacb52fff02ace8eb134ea084fe282
https://doi.org/10.1021/jm9014197
https://doi.org/10.1021/jm9014197
Autor:
Ramesh A. Bhat, Rachelle L. Samuel, Jennifer L. Andrews, Peter V.N. Bodine, Frederick J. Bex, Valerie E. Coleburn, Richard J. Murrills, Bheem M. Bhat
Publikováno v:
Journal of Cellular Biochemistry. 106:887-895
Parathyroid hormone (PTH) activates multiple signaling pathways following binding to the PTH1 receptor in osteoblasts. Previous work revealed a discrepancy between cAMP stimulation and CRE reporter activation of truncated PTH peptides, suggesting tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbd8ae7072806e8e44d9f5e416325cb
https://doi.org/10.1002/jcb.22057
https://doi.org/10.1002/jcb.22057
Autor:
Anthony Anisowicz, Catherine McCauley, Valerie E. Coleburn, Art Morales, Frederick J. Bex, Paul J. Yaworsky, Bheem M. Bhat, James R. Graham, Eric Fortier, Wei Liu, Kristina Allen, Ramesh A. Bhat, Michael Cain, Ho-Sun Lam
Publikováno v:
Gene. 391:103-112
A single point mutation (G to T) in the low-density lipoprotein receptor related protein 5 (LRP5) gene results in a glycine to valine amino acid change (G171V) and is responsible for an autosomal dominant high bone mass trait (HBM) in two independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1c5e29df928065d39b01251db93d1f
https://doi.org/10.1016/j.gene.2006.12.014
https://doi.org/10.1016/j.gene.2006.12.014
Autor:
Linda Sauter, Robert R. Recker, Mark L. Johnson, Barry S. Komm, Moitreyee Chatterjee-Kishore, Frederick J. Bex, Yogendra P. Kharode, Paul J. Yaworsky, Weiguang Zhao, Philip Babij, Mohammed P. Akhter, Andrew A. Hill, Eugene L. Brown, Christine Li, Diane M. Cullen, John A. Robinson
Publikováno v:
Journal of Biological Chemistry. 281:31720-31728
A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the high bone mass LRP5 G171V transgenic mice demonstrated increased expression of canonical Wnt pathway and Wnt/beta-catenin target genes compared with non-tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f1c0d8555f2048d7e2ee96371d9238
https://doi.org/10.1074/jbc.m602308200
https://doi.org/10.1074/jbc.m602308200
Autor:
Peter V.N. Bodine, Yogendra P. Kharode, Barry S. Komm, Laura M. Seestaller-Wehr, Frederick J. Bex
Publikováno v:
Journal of Cellular Physiology. 210:352-357
Secreted frizzled-related protein (sFRP)-1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41a02599e006cfbea793cff3a134897
https://doi.org/10.1002/jcp.20834
https://doi.org/10.1002/jcp.20834
Autor:
Peter V.N. Bodine, Ramesh A. Bhat, Frederick J. Bex, John A. Robinson, Julia Billiard, Barry S. Komm
Publikováno v:
Clinical Reviews in Bone and Mineral Metabolism. 4:73-96
Regulation of canonical Wnt signaling in osteoblasts has been shown to play an important role in bone formation. Loss-of-function mutations in the Wnt co-receptor, low-density lipoprotein receptor-related protein (LRP)5, cause osteoporosis pseudoglio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405f5aa1622b4fdb83b925050c980ad9
https://doi.org/10.1385/bmm:4:2:73
https://doi.org/10.1385/bmm:4:2:73
Autor:
Kees Kenneth L, Valerie E. Coleburn, Frederick J. Bex, Horace Fletcher, Bheem M. Bhat, Jeanne J. Matteo, Richard J. Murrills, Charles William Mann, Diane B. Hauze
Publikováno v:
Letters in Drug Design & Discovery. 2:201-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa51cedc0eef3cefda7e99a59354d7cd
https://doi.org/10.2174/1570180053765110
https://doi.org/10.2174/1570180053765110
Autor:
Jeanne J. Matteo, Valerie E. Coleburn, Bheem M. Bhat, Rachelle L. Samuel, Richard J. Murrills, Yogendra P. Kharode, Jennifer L. Andrews, Frederick J. Bex
Publikováno v:
Bone. 35:1263-1272
There is considerable evidence implicating the cAMP-signaling pathway in the anabolic action of PTH; and to date, all PTH and PTHrp peptides that stimulate cyclic AMP are active in animal models of osteogenesis. We have tested two C-terminally trunca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f891e82c05796a3a4a7dfc0bf268918a
https://doi.org/10.1016/j.bone.2004.08.015
https://doi.org/10.1016/j.bone.2004.08.015
Autor:
Barry S. Komm, Gadi Turgeman, Peter V.N. Bodine, Luis E. Borella, Shuanhu Zhou, Yogendra P. Kharode, Yoram Zilberman, Dan Gazit, Frederick J. Bex, Ioannis Moutsatsos, Pam Kelly
Publikováno v:
Journal of Cellular Biochemistry. 86:461-474
Osteoporosis is a disease manifested in drastic bone loss resulting in osteopenia and high risk for fractures. This disease is generally divided into two subtypes. The first, post-menopausal (type I) osteoporosis, is primarily related to estrogen def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a906d0a4fe41159581edfaab3fe91605
https://doi.org/10.1002/jcb.10231
https://doi.org/10.1002/jcb.10231