Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Frederick J. Miller"'
Autor:
Renaud Vincent, Premkumari Kumarathasan, Patrick Goegan, Stephen G. Bjarnason, Josée Guénette, Subramanian Karthikeyan, Errol M. Thomson, Ian Y. Adamson, William P. Watkinson, Bruno Battistini, Frederick J. Miller
Publikováno v:
Chemosphere. 296
Short-term increases in particulate matter (PM) are associated with heightened morbidity and mortality from cardiovascular causes. Inhalation of PM is known to increase endothelin (ET)-1 levels. Yet, less is known about particle composition-related c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d7535fa1e3efce9004415de500aa3
https://pubmed.ncbi.nlm.nih.gov/35157883
https://pubmed.ncbi.nlm.nih.gov/35157883
Autor:
Bahman Asgharian, Frederick J. Miller, Timothy B. Bentley, Owen T. Price, Jeffry D. Schroeter, Daniel R. Einstein, Richard A. Corley
Publikováno v:
Journal of Aerosol Science. 99:107-124
Despite increasing use of pigs as surrogates for humans in inhalation studies, measurements of particle deposition in the lungs of pigs are lacking. No comprehensive models are available for deposition of inhaled particles in the lungs of pigs to bri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1845a428e21c56e7aaae66e5a2bb8f70
https://doi.org/10.1016/j.jaerosci.2016.01.016
https://doi.org/10.1016/j.jaerosci.2016.01.016
Publikováno v:
Journal of Aerosol Science. 99:14-26
A little over a decade ago, the first UC Irvine dosimetry conference was held entitled “Frontiers in Aerosol Dosimetry Research”. At that time, mechanistic dosimetry models, such as the multiple path particle dosimetry (MPPD) model, primarily foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8304d7f463c57ebb0ebe006632a3c042
https://doi.org/10.1016/j.jaerosci.2016.01.018
https://doi.org/10.1016/j.jaerosci.2016.01.018
Publikováno v:
Inhalation toxicology. 29(12-14)
Study of the mode of action (MOA) relating exposure to a given chemical with an associated adverse outcome is an iterative process with each iteration driven by new understandings of the relevant biology. Here, we revisit a previously described, MOA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e309c9198ac6c7dd4d1c27773222c5
https://pubmed.ncbi.nlm.nih.gov/29405084
https://pubmed.ncbi.nlm.nih.gov/29405084
Autor:
Frederick J. Miller, Judith A. Graham
Publikováno v:
Indoor Air and Human Health ISBN: 9781351073479
Indoor Air and Human Health
Indoor Air and Human Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ff6b6fad8b6e68f8d288b9743f43e4
https://doi.org/10.1201/9781351073479-26
https://doi.org/10.1201/9781351073479-26
Publikováno v:
Inhalation Toxicology. 17:317-334
Direct calculation of delivered dose in the species of interest potentially affects the magnitude of an uncertainty factor needed to address extrapolation of laboratory animal data to equivalent human exposure scenarios, thereby improving the accurac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853e3acff80538ff04b06c9117b0230e
https://doi.org/10.1080/08958370590929394
https://doi.org/10.1080/08958370590929394
Autor:
Frederick J. Miller, Daniel L. Costa, Margaret G. Menache, Ling-Yi Chang, Judith A. Graham, B. L. Stockstill, Ying Huang, Elaine C. Grose, James D. Crapo
Publikováno v:
Toxicology and Applied Pharmacology
Electron microscopic morphometry was used to study the development of lung injury during and after chronic (78 weeks) exposure to a pattern of ozone (O3) designed to simulate high urban ambient concentrations that occur in some environments. The dail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3333f525ed2b35521f477d52a147fe44
http://europepmc.org/articles/PMC7130134
http://europepmc.org/articles/PMC7130134
Autor:
Rory B. Conolly, Paul M. Schlosser, Frederick J. Miller, Julia S. Kimbell, Darin Kalisak, Julian Preston, Derek B. Janszen
Publikováno v:
Toxicological Sciences. 82:279-296
Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are of interest, since epidemiological studies have provided only equivocal evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a137f18ff49a58ab4d2201ce331a2b8
https://doi.org/10.1093/toxsci/kfh223
https://doi.org/10.1093/toxsci/kfh223
Autor:
Senthil Kabilan, Richard A. Corley, Jeffry D. Schroeter, Bahman Asgharian, Owen T. Price, Timothy C. Cox, Daniel R. Einstein, Richard E. Jacob, Frederick J. Miller, Timothy B. Bentley
Publikováno v:
Inhalation toxicology. 26(9)
While inhalation toxicological studies of various compounds have been conducted using a number of different strains of rats, mechanistic dosimetry models have only had tracheobronchial (TB) structural data for Long-Evans rats, detailed morphometric d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efb3e74643507eb623cd648fa82abc2
https://pubmed.ncbi.nlm.nih.gov/25055841
https://pubmed.ncbi.nlm.nih.gov/25055841
Autor:
Frederick J. Miller, J. H. Overton, Julia S. Kimbell, Ravi P. Subramaniam, Paul M. Schlosser, K. T. Morgan, Rory B. Conolly
Publikováno v:
Toxicological Sciences. 64:111-121
Interspecies extrapolations of tissue dose and tumor response have been a significant source of uncertainty in formaldehyde cancer risk assessment. The ability to account for species-specific variation of dose within the nasal passages would reduce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c11f00a83c5097b3758981f99cbed9a
https://doi.org/10.1093/toxsci/64.1.111
https://doi.org/10.1093/toxsci/64.1.111