Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Frederick J Mitchelson"'
Autor:
Frederick J Mitchelson
Publikováno v:
Pharmacology & Therapeutics. 135:216-245
The unusual pharmacology of McN-A-343 was first described by Roszowski in 1961. The agonist appeared to be a selective stimulant of muscarinic receptors in sympathetic ganglia, now known to be the muscarinic M₁ receptor subtype. However, subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ee7c559230bbc6d1d5b26354d00032
https://doi.org/10.1016/j.pharmthera.2012.05.008
https://doi.org/10.1016/j.pharmthera.2012.05.008
Autor:
Frederick J Mitchelson, Elizabeth Burcher, Kate H. Moore, Richard J. Millard, Kylie J Mansfield, Lu Liu
Publikováno v:
British Journal of Pharmacology. 144:1089-1099
1. We investigated muscarinic receptors in the detrusor and mucosa of the human bladder body. Radioligand-binding studies with [(3)H]QNB were conducted using specimens collected from patients (36-77 years) with normal bladder function, undergoing sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f762c4850bf75d8243d09a893b1f0a1
https://doi.org/10.1038/sj.bjp.0706147
https://doi.org/10.1038/sj.bjp.0706147
Publikováno v:
Receptors and Channels. 9:241-260
Signaling pathways for muscarinic acetylcholine receptors (mAChRs) include several enzymes and ion channels. Recent studies have revealed the importance of various isoforms of both α and βγ subunits of G proteins in initiation of signaling as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071d109fbee7d4e6b6e909735101b90a
https://doi.org/10.3109/10606820308263
https://doi.org/10.3109/10606820308263
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 363:133-138
The effects of histamine and the more selective H3 receptor agonist (R)alpha-methylhistamine were investigated on contractile responses produced by electrical stimulation of the longitudinal and circular muscles of the rat ileum and the circular musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0993fd895b512b6b79e52920ef9a65
https://doi.org/10.1007/s002100000345
https://doi.org/10.1007/s002100000345
Publikováno v:
Journal of Autonomic Pharmacology. 20:193-206
1. We review literature demonstrating (a) the presence and (b) the actions of substances that mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma of a number of species including man. 2. In all species studied pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8343634fd56966e78dbcf4b8ff8556c3
https://doi.org/10.1046/j.1365-2680.2000.00195.x
https://doi.org/10.1046/j.1365-2680.2000.00195.x
Publikováno v:
European Journal of Pharmacology. 402:161-169
The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bab323fb15885de6d0bdb1c51bce5aa
https://doi.org/10.1016/s0014-2999(00)00489-1
https://doi.org/10.1016/s0014-2999(00)00489-1
Publikováno v:
British Journal of Pharmacology. 130:1013-1020
1. Functional experiments have been conducted to assess the effects of acetylcholine and carbachol, and the receptors on which they act to facilitate neurotransmission to the stromal smooth muscle of the prostate gland of the guinea-pig. 2. Acetylcho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9a1a826afbceeae68adcfb9911e2be
https://doi.org/10.1038/sj.bjp.0703409
https://doi.org/10.1038/sj.bjp.0703409
Publikováno v:
Neuropeptides. 34:12-17
The aim of this study was to determine whether tachykinin receptors might be involved in the mediation of the atropine- and capsaicin-sensitive third phase of a triphasic contractile response to vagal nerve stimulation of the guinea-pig isolated oeso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2149a2de86c7a99ad7ed92d2ed8a077
https://doi.org/10.1054/npep.1999.0780
https://doi.org/10.1054/npep.1999.0780
Publikováno v:
European Journal of Pharmacology. 387:265-272
The aim of the present study was to identify 5-hydroxytryptamine(7) (5-HT(7)) binding sites in the mouse ileum, where the presence of mRNA for the receptor has been reported. Studies were performed using [3H]mesulergine, an antagonist with high affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c38951e9c8b90fa13687dd87b01bed
https://doi.org/10.1016/s0014-2999(99)00797-9
https://doi.org/10.1016/s0014-2999(99)00797-9
Publikováno v:
British Journal of Pharmacology. 127:1091-1098
Experiments have been conducted to investigate the actions of endothelins on the guinea-pig prostate gland. Saturation experiments with [125I]-endothelin-1 (2–800 pM) in guinea-pig prostatic homogenates indicated the presence of high affinity bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e859140247b6d306ae048db8ed04a47
https://doi.org/10.1038/sj.bjp.0702644
https://doi.org/10.1038/sj.bjp.0702644