Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.

Autor: Therese Andersson, Sabhi Rahman, Stephen N Sansom, Jessica M Alsiö, Masahiro Kaneda, James Smith, Donal O'Carroll, Alexander Tarakhovsky, Frederick J Livesey

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13453 (2010)

To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all mi

Externí odkaz: https://doaj.org/article/3a56cd386e65468bb48c5eae610ec0ef

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

Autor: Stephen N Sansom, Dean S Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L Rubenstein, Frederick J Livesey

Publikováno v: PLoS Genetics, Vol 5, Iss 6, p e1000511 (2009)

Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell prolifera

Externí odkaz: https://doaj.org/article/7065e74b9a8841d39c3ee6300bb777b0

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

Autor: Christy Hung, Eleanor Tuck, Victoria Stubbs, Sven J. van der Lee, Cora Aalfs, Resie van Spaendonk, Philip Scheltens, John Hardy, Henne Holstege, Frederick J. Livesey

Publikováno v: Cell Reports, Vol 35, Iss 11, Pp 109259- (2021)

Summary: Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer’s disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer’s disease, and SORL1 varia

Externí odkaz: https://doaj.org/article/2806293dc8bf440ca1a2cd951d19946a

Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry

Autor: Ioakeim Ampartzidis, Christoforos Efstathiou, Francesco Paonessa, Elliott M Thompson, Tyler Wilson, Conor J McCann, Nicholas DE Greene, Andrew Copp, Frederick J Livesey, Nicola Elvassore, Giovanni Giuseppe Giobbe, Paolo De Coppi, Eirini Maniou, Gabriel L Galea

Publikováno v: Developmental biology.

Neuroepithelial cells balance tissue growth requirement with the morphogenetic imperative of closing the neural tube. They apically constrict to generate mechanical forces which elevate the neural folds, but are thought to apically dilate during mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67494b7335124d1202d3303c853afd98
https://pubmed.ncbi.nlm.nih.gov/36509125

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

Autor: John Hardy, Sven J. van der Lee, Henne Holstege, Resie M. L. van Spaendonk, Frederick J. Livesey, Victoria Stubbs, Eleanor Tuck, Christy Hung, Cora Aalfs, Philip Scheltens

Publikováno v: Hung, C, Tuck, E, Stubbs, V, van der Lee, S J, Aalfs, C, van Spaendonk, R, Scheltens, P, Hardy, J, Holstege, H & Livesey, F J 2021, ' SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network ', Cell Reports, vol. 35, no. 11, 109259 . https://doi.org/10.1016/j.celrep.2021.109259
Cell Reports
Cell Reports, 35(11):109259. Cell Press
Cell Reports, 35(11)
Cell Reports, Vol 35, Iss 11, Pp 109259-(2021)

Summary Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer’s disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer’s disease, and SORL1 varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58a569b76287149c22ec09d4a21d3cf
https://research.vumc.nl/en/publications/64053ab8-a8c5-4e83-b861-2630dac3aab8