Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Frederick J, Suchy"'
Autor:
Antonia Felzen, Daan B.E. van Wessel, Emmanuel Gonzales, Richard J. Thompson, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, Jan B.F. Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Enke Grabhorn, Steffen Hartleif, Wendy J. van der Woerd, Binita M. Kamath, Jian-She Wang, Liting Li, Özlem Durmaz, Nanda Kerkar, Marianne Hørby Jørgensen, Ryan Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Noemie Laverdure, Cristina Targa Ferreira, Felipe Ordoñez Guerrero, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa de Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Aglaia Zellos, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick J. McKiernan, Philip Rosenthal, Yumirle Turmelle, Simon Horslen, Kathleen Schwarz, Jorge A. Bezerra, Kasper Wang, Bettina E. Hansen, Henkjan J. Verkade
Publikováno v:
JHEP Reports, Vol 5, Iss 2, Pp 100626- (2023)
Background & Aims: Bile salt export pump (BSEP) deficiency frequently necessitates liver transplantation in childhood. In contrast to two predicted protein truncating mutations (PPTMs), homozygous p.D482G or p.E297G mutations are associated with rela
Externí odkaz:
https://doaj.org/article/bbb97439dbff47198444dd0e83e7f0cb
Autor:
Natarajan Balasubramaniyan, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol, Frederick J. Suchy
Publikováno v:
Hepatology Communications, Vol 3, Iss 12, Pp 1674-1686 (2019)
Adenosine triphosphate–binding cassette subfamily C member 2 (ABCC2/Abcc2) is critically important to biliary excretion of many endobiotic and xenobiotic compounds, and is a major driving force for bile acid–independent bile flow. Abcc2 expressio
Externí odkaz:
https://doaj.org/article/aebd4adb52da46959b40f92d286b48d8
Autor:
Karim C. El Kasmi, Padade M. Vue, Aimee L. Anderson, Michael W. Devereaux, Swati Ghosh, Natarajan Balasubramaniyan, Sophie A. Fillon, Carola Dahrenmoeller, Ayed Allawzi, Crystal Woods, Sarah McKenna, Clyde J. Wright, Linda Johnson, Angelo D’Alessandro, Julie A. Reisz, Eva Nozik-Grayck, Frederick J. Suchy, Ronald J. Sokol
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on
Externí odkaz:
https://doaj.org/article/2a266070415e43ab8b818dd620dfebf5
Autor:
Francesca Aguilo, SiDe Li, Natarajan Balasubramaniyan, Ana Sancho, Sabina Benko, Fan Zhang, Ajay Vashisht, Madhumitha Rengasamy, Blanca Andino, Chih-hung Chen, Felix Zhou, Chengmin Qian, Ming-Ming Zhou, James A. Wohlschlegel, Weijia Zhang, Frederick J. Suchy, Martin J. Walsh
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 479-492 (2016)
The Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a transcriptional co-activator that plays a central role in adapted metabolic responses. PGC-1α is dynamically methylated and unmethylated at the residue K779 by t
Externí odkaz:
https://doaj.org/article/4ddbc33d3daa49898928b13d47416b8c
Autor:
Michael W. Devereaux, Frederick J. Suchy, Angelo D'Alessandro, Ronald J. Sokol, Swati Ghosh, Colin T. Shearn, Karim C. El Kasmi, David J. Orlicky, Aimee L. Anderson, Natarajan Balasubramaniyan
Publikováno v:
Hepatology. 75:252-265
Parenteral nutrition (PN)-associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1β derived from activated hepatic macrophages to suppress h
Autor:
Shuhua Xu, Carol J Soroka, An-Qiang Sun, Donald S Backos, Albert Mennone, Frederick J Suchy, James L Boyer
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158269 (2016)
The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization
Externí odkaz:
https://doaj.org/article/d50aac9e0e4849489dda2f9e20503fbb
Autor:
David J. Orlicky, Frederick J. Suchy, Aimee L. Anderson, Colin T. Shearn, Michael W. Devereaux, Ronald J. Sokol, Karim C. El Kasmi, Natarajan Balasubramaniyan
Publikováno v:
JPEN. Journal of parenteral and enteral nutritionREFERENCES. 46(5)
BACKGROUND We have recently reported a mouse model of PN-associated cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of canalicular bi
Autor:
Natarajan Balasubramaniyan, Frederick J. Suchy, David J. Orlicky, Ronald J. Sokol, Michael W. Devereaux
Publikováno v:
The Journal of Biological Chemistry
ATP-binding cassette, sub-family B member 11 (ABCB11) is an efflux transporter for bile acids on the liver canalicular membrane. The expression of this transporter is reduced in cholestasis; however, the mechanisms contributing to this reduction are
Autor:
Liting Li, Jian-She Wang, Ozlem Durmaz, Felipe Ordonez, Wikrom Karnsakul, Seema Alam, Cristina Targa Ferreira, Natural Course, Bettina E. Hansen, Kyung Mo Kim, Etienne Sokal, Ryan T. Fischer, Valerie Sency, Estella M. Alonso, Simon Horslen, Elisa de Carvalho, Piotr Czubkowski, Emanuele Nicastro, Nanda Kerkar, Dieter C. Broering, Björn Fischler, Dorothee Krebs-Schmitt, Kathleen M. Loomes, Dominique Debray, Marianne Hørby Jørgensen, Benjamin L. Shneider, Emmanuel Gonzales, Cigdem Arikan, Nathalie Rock, Antal Dezsőfi, Tassos Grammatikopoulos, Steffen Hartleif, Mara Cananzi, Talal Algoufi, Ronald J. Sokol, Jan B F Hulscher, Carolina Jimenez-Rivera, Emmanuel Jacquemin, Anne Spraul, Henkjan J. Verkade, Patryk Lipiński, Daan B E van Wessel, Nejat Mazhar, Maria Rogalidou, Deirdre Kelly, Alexandre Fabre, Daniele Serranti, Pier Luigi Calvo, Yael Mozer-Glassberg, Richard J. Thompson, Cristina Goncalves, Yumirle P. Turmelle, Jesus Quintero Bernabeu, Agustina Kadaristiana, Florence Lacaille, Loreto Hierro, Mohammad Shagrani, Patrick J. McKiernan, Girish S. Rao, Gema Muñoz Bartolo, Huey-Ling Chen, Wendy L. van der Woerd, Irena Jankowska, Amer Azaz, Philip J. Rosenthal, Frederick J. Suchy, Jernej Brecelj, Gabriella Nebbia, Noemie Laverdure, Henrik Arnell, Binita M. Kamath, Heng Wang
Publikováno v:
Hepatology
Hepatology, Wiley-Blackwell, 2021, 74 (2), pp.892-906. ⟨10.1002/hep.31787⟩
Hepatology, 74(2), 892-906. Wiley
Hepatology, Vol. 74, no. 2, p. 892-906 (2021)
Hepatology (Baltimore, Md.)
Hepatology, Wiley-Blackwell, 2021, 74 (2), pp.892-906. ⟨10.1002/hep.31787⟩
Hepatology, 74(2), 892-906. Wiley
Hepatology, Vol. 74, no. 2, p. 892-906 (2021)
Hepatology (Baltimore, Md.)
Mutations in ATP8B1 can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive familial intrahepatic cholestasis type 1 (PFIC1). The rarity of FIC1 deficiency has largely prevented a detailed analysis of its natural histor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecc4ae32d84b425ddef55c91928639e
https://hal-amu.archives-ouvertes.fr/hal-03663238
https://hal-amu.archives-ouvertes.fr/hal-03663238
Autor:
Sandrine Dubrac, Steven R. Lear, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Jaya Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Patricia J. Blanche, Ronald M. Krauss, Ashok K. Batta, Gerald Salen, Frederick J. Suchy, Nobuyo Maeda, Sandra K. Erickson
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 1, Pp 76-85 (2005)
The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendi
Externí odkaz:
https://doaj.org/article/f6777aacfb9c46448d115da3c88a52e5