Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Frederick H. Leibach"'
Publikováno v:
Textbook of Gastroenterology
Publikováno v:
Journal of Neurochemistry. 70:922-931
We have cloned a sigma receptor from rat brain and established its functional identity using a heterologous expression system. The cloned cDNA (1,582 bp long) codes for a protein of 223 amino acids that possesses a single putative transmembrane domai
Autor:
Puttur D. Prasad, Mitsuru Sugawara, Frederick H. Leibach, Takuya Fujita, Christy C. Bridges, Vadivel Ganapathy, Ruan Ling
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1512:15-21
We investigated the molecular mechanism involved in the adaptive regulation of the amino acid transport system A, a process in which amino acid starvation induces the transport activity. These studies were done with rat C6 glioma cells. System A acti
Autor:
Frederick H. Leibach, Malliga E. Ganapathy, Takahiro Hatanaka, Wei Huang, Takeo Nakanishi, Vadivel Ganapathy, Puttur D. Prasad
Publikováno v:
Journal of Clinical Investigation. 107:1035-1043
Nitric oxide synthase (NOS) inhibitors have therapeutic potential in the management of numerous conditions in which NO overproduction plays a critical role. Identification of transport systems in the intestine that can mediate the uptake of NOS inhib
Autor:
Vadivel Ganapathy, Frederick H. Leibach, Wei Huang, Puttur D. Prasad, Takahiro Hatanaka, Takeo Nakanishi, Malliga E. Ganapathy
Publikováno v:
The Journal of Physiology. 532:297-304
Carnitine (β-hydroxy-γ-trimethylaminobutyrate) is an obligate requirement for β-oxidation of long-chain fatty acids. It is synthesized endogenously in humans in the liver and kidney (Carter et al. 1995). It is also absorbed in the intestinal tract
Autor:
Frederick H. Leibach, Takeo Nakanishi, You Jun Fei, Robert G. Martindale, Malliga E. Ganapathy, Mitsuru Sugawara, Vadivel Ganapathy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1509(1-2):7-13
To date, two different transporters that are capable of transporting α-(methylamino)isobutyric acid, the specific substrate for amino acid transport system A, have been cloned. These two transporters are known as ATA1 and ATA2. We have cloned a thir
Autor:
You-Jun Fei, Vadivel Ganapathy, Frederick H. Leibach, Wei Huang, Mitsuru Sugawara, Malliga E. Ganapathy
Publikováno v:
Journal of Pharmaceutical Sciences. 89:781-789
In clinical trials, valganciclovir, the valyl ester of ganciclovir, has been shown to enhance the bioavailability of ganciclovir when taken orally by patients with cytomegalovirus infection. We investigated the role of the intestinal peptide transpor
Autor:
Ronald L. George, Xiang Wu, Simon J. Conway, Wei Huang, Haiping Wang, Vadivel Ganapathy, Frederick H. Leibach
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1466(1-2):315-327
This report describes the structure, function, and tissue distribution pattern of rat OCTN1 (novel organic cation transporter 1). The rat OCTN1 cDNA was isolated from a rat placental cDNA library. The cDNA is 2258 bp long and codes for a protein of 5
Autor:
Frederick H. Leibach, Haiping Wang, Teresa L. Yang-Feng, Vadivel Ganapathy, You Jun Fei, Ramesh Kekuda, Puttur D. Prasad, Lawrence D. Devoe
Publikováno v:
American Journal of Physiology-Cell Physiology. 278:C1019-C1030
We have cloned and functionally characterized the human Na+-dependent high-affinity dicarboxylate transporter (hNaDC3) from placenta. The hNaDC3 cDNA codes for a protein of 602 amino acids with 12 transmembrane domains. When expressed in mammalian ce
Autor:
Haiping Wang, Frederick H. Leibach, Vadivel Ganapathy, Lawrence D. Devoe, Puttur D. Prasad, Sonne R. Srinivas
Publikováno v:
Biochemical and Biophysical Research Communications. 270:836-840
We report on the electrogenic nature of the transport process mediated by the rat sodium-dependent multivitamin transporter. In Cos-7 cells, the relationship of Na+ concentration versus biotin and pantothenate uptake rate was sigmoidal with a Na+:sub