Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Frederick F. Lang"'
Autor:
Chibawanye I. Ene, Christina Abi Faraj, Thomas H. Beckham, Jeffrey S. Weinberg, Clark R. Andersen, Ali S. Haider, Ganesh Rao, Sherise D. Ferguson, Christopher A. Alvarez-Brenkenridge, Betty Y. S. Kim, Amy B. Heimberger, Ian E. McCutcheon, Sujit S. Prabhu, Chenyang Michael Wang, Amol J. Ghia, Susan L. McGovern, Caroline Chung, Mary Frances McAleer, Martin C. Tom, Subha Perni, Todd A. Swanson, Debra N. Yeboa, Tina M. Briere, Jason T. Huse, Gregory N. Fuller, Frederick F. Lang, Jing Li, Dima Suki, Raymond E. Sawaya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radi
Externí odkaz:
https://doaj.org/article/e8e236bc0bdc4fe488f94bae47c605e4
Autor:
Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 54, Iss , Pp 101008- (2024)
Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs)
Externí odkaz:
https://doaj.org/article/97980fdf54b14666a16e35b8b917352e
Autor:
Daniel H. Wang, Yoko Fujita, Antonio Dono, Ana G. Rodriguez Armendariz, Mauli Shah, Nagireddy Putluri, Pavel S. Pichardo-Rojas, Chirag B. Patel, Jay-Jiguang Zhu, Jason T. Huse, Brittany C. Parker Kerrigan, Frederick F. Lang, Yoshua Esquenazi, Leomar Y. Ballester
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility of CSF biomarkers. While some studies show the utility of CSF cell-free DNA analysis,
Externí odkaz:
https://doaj.org/article/f82f5120ed804f83a99b54df035f690c
Autor:
Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients. Epigenetic alterations have been well documented in
Externí odkaz:
https://doaj.org/article/8cf1141c8fd94cffbd85efb1ee005dde
Autor:
Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William F. Flynn, Ruli Gao, David S. Baskin, Kumar Pichumani, Omkar B. Ijare, Stephanie L. Wood, Suzanne Z. Powell, David L. Haviland, Brittany C. Parker Kerrigan, Frederick F. Lang, Sujit S. Prabhu, Kristin M. Huntoon, Wen Jiang, Betty Y. S. Kim, Joshy George, Kyuson Yun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Glioblastoma (GBM) is an immune cold tumour that is refractory to immunotherapy. Here, the authors identify molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and propose S100A4 as a regu
Externí odkaz:
https://doaj.org/article/8729e15cfe464e098e0bc6e28aafb086
Autor:
Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. L. Bhat, Thanh-Thuy T. Le, Floris P. Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G. W. Verhaak, Kenneth D. Aldape, Erik P. Sulman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood. We demonstrate that podoplanin (PDPN) expression is an indepe
Externí odkaz:
https://doaj.org/article/17361cb6986142ceaa84f9b6ee8f62af
Autor:
Filipa Godoy-Vitorino, Hong Jiang, W Jim Zheng, Frederick F Lang, Joy Gumin, Lisha Zhu, Candelaria Gomez-Manzano, Juan Fueyo, Derek A Wainwright, Dong Ho Shin, Teresa T Nguyen, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Xuejun Fan, Christopher Alvarez-Breckenridge, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Oncolytic viruses are considered part of immunotherapy and have shown promise in preclinical experiments and clinical trials. Results from these studies have suggested that tumor microenvironment remodeling is required to achieve an effect
Externí odkaz:
https://doaj.org/article/1f2db7df16d848f1a1f3ecf672c1450b
Autor:
Vinodh A. Kumar, Islam M. Heiba, Sujit S. Prabhu, Melissa M. Chen, Rivka R. Colen, Angela L. Young, Jason M. Johnson, Ping Hou, Kyle Noll, Sherise D. Ferguson, Ganesh Rao, Frederick F. Lang, Donald F. Schomer, Ho-Ling Liu
Publikováno v:
Cancer Imaging, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Task-based functional MRI (tb-fMRI) is a well-established technique used to identify eloquent cortex, but has limitations, particularly in cognitively impaired patients who cannot perform language paradigms. Resting-state function
Externí odkaz:
https://doaj.org/article/90d997b0e1894cda9622f4d9ec07233d
Autor:
Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for explor
Externí odkaz:
https://doaj.org/article/379bf84492484b43b2eac920159ae273
Autor:
Martina Ott, Karl-Heinz Tomaszowski, Anantha Marisetty, Ling-Yuan Kong, Jun Wei, Maya Duna, Katia Blumberg, Xiaorong Ji, Carmen Jacobs, Gregory N. Fuller, Lauren A. Langford, Jason T. Huse, James P. Long, Jian Hu, Shulin Li, Jeffrey S. Weinberg, Sujit S. Prabhu, Raymond Sawaya, Sherise Ferguson, Ganesh Rao, Frederick F. Lang, Michael A. Curran, Amy B. Heimberger
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
In order to prioritize available immune therapeutics, immune profiling across glioma grades was conducted, followed by preclinical determinations of therapeutic effect in immune-competent mice harboring gliomas. T cells and myeloid cells were isolate
Externí odkaz:
https://doaj.org/article/bd19fbd424ce488a8909a2a850262eae