Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Frederick E. Tan"'
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109517- (2021)
Summary: RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best know
Externí odkaz:
https://doaj.org/article/3e63499391674b86a95fc19b3b9041b2
Autor:
En-Ching Luo, Anthony Q. Vu, Eric Kofman, Sandra L Leibel, Aaron F. Carlin, Eric L. Van Nostrand, Jonathan C. Schmok, Elizabeth M. Kwong, Danielle Schafer, Brian A. Yee, Gene W. Yeo, Jasmine R. Mueller, Frederick E. Tan, Joy Shengnan Xiang, Yan Song, Kristopher W. Brannan, Alexandra T. Tankka, Yanhua Li, Phuong Le, Kevin D. Dong, Hsuan-Lin Her, Samuel S. Park, Krysten Leigh Jones, Rachael N. McVicar, Chun-Yuan Chen, Wenhao Jin
Publikováno v:
SSRN Electronic Journal.
The COVID-19 pandemic was caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs. SARS-CoV-2 proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8325d3972ef205518f90d9b11f87cc
https://doi.org/10.2139/ssrn.3867726
https://doi.org/10.2139/ssrn.3867726
Autor:
Sebastian Markmiller, Joshua L. Schwartz, David E. Hill, Gene W. Yeo, Archana Shankar, Jonathan C. Schmok, Gabriel A. Pratt, Duy B. Scaletta, Brian A. Yee, Stefan Aigner, Frederick E. Tan, Shashank Sathe, Jason L. Nathanson, Yuanchi Ha, En-Ching Luo
Publikováno v:
Nature structural & molecular biology, vol 27, iss 10
Nat Struct Mol Biol
Nat Struct Mol Biol
The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c24a6237dec4ffeb782ed4b0b5f261
https://escholarship.org/uc/item/5kd0v4kq
https://escholarship.org/uc/item/5kd0v4kq
Autor:
Shenghong Ma, Kun-Liang Guan, Kimberly C. Lin, Bing Ren, Zhen Ye, Jerrell L. Moore rd, Yunjiang Qiu, Frederick E. Tan, Steven W. Plouffe
Publikováno v:
The Journal of biological chemistry, vol 293, iss 28
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the transcriptional co-activators Yes-associated protein (YAP) and WW domain-containing transcription regulator 1 (WWTR1 or TAZ), are responsible for media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb535a497645e92d539b1e31757cfa5
https://doi.org/10.1074/jbc.ra118.002715
https://doi.org/10.1074/jbc.ra118.002715
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109517-(2021)
Cell reports
Cell reports
SUMMARY RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cb277fc0d59adcd30c11b6ababb011
https://doi.org/10.1016/j.celrep.2021.109517
https://doi.org/10.1016/j.celrep.2021.109517
Autor:
Shashank Sathe, Gene W. Yeo, Frederick E. Tan, Julia K. Nussbacher, Samson Peter, Emily C. Wheeler
LIN28 RNA binding proteins are dynamically expressed throughout mammalian development and during disease. However, it remains unclear how changes in LIN28 expression define patterns of post-transcriptional gene regulation. Here we show that LIN28 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da5f4c49562e1dfbdca568929539a3e
https://europepmc.org/articles/PMC6338497/
https://europepmc.org/articles/PMC6338497/
Autor:
David Bakhshinyan, Marc Remke, En-Ching Luo, Kristin Hope, Provias John, Sansi Xing, Raymond G. Fox, Jason Moffat, Gene W. Yeo, Yu Lu, Frederick E. Tan, Ashley Adile, Chitra Venugopal, Helen He Zhu, Kevin R. Brown, Brian A. Yee, Minomi Subapanditha, Jüri Reimand, Agata Xella, Tannishitha Reya, Adam Fleming, Michelle Kameda-Smith, Robert J. Wechsler-Reya, Daniel Picard, Sheila K. Singh
Publikováno v:
Neuro-Oncology
Medulloblastoma (MB) is the most common solid malignant pediatric brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d62f398119b5f1086b87754a1af009
http://europepmc.org/articles/PMC7715904
http://europepmc.org/articles/PMC7715904
Publikováno v:
Bioconjugate Chemistry. 15:931-941
We designed and synthesized new dextran-peptide-methotrexate conjugates for tumor-targeted delivery of chemotherapeutics via the mediation of matrix metalloproteinase II (MMP-2) and matrix metalloproteinase IX (MMP-9), both being widely known tumor-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e873ef282876d7bfad9c33b50807ea
https://doi.org/10.1021/bc0499174
https://doi.org/10.1021/bc0499174
Autor:
Frederick E. Tan, Gene W. Yeo
Publikováno v:
Molecular Cell. 61(1):1-2
Lin28, a well-known RNA-binding protein, regulates diverse cellular properties. All physiological functions of Lin28A characterized so far have been attributed to its repression of let-7 miRNA biogenesis or modulation of mRNA translational efficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecb2c70f258fcc2a61b67bafca8d8dd
Autor:
Frederick E. Tan, Michael B. Elowitz
AU-rich element mRNA-binding proteins (AUBPs) are key regulators of development, but how they are controlled and what functional roles they play depends on cellular context. Here, we show that Brf1 (zfp36l1), an AUBP from the Zfp36 protein family, op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7823bf75201854f486b84cdafb83df1f
https://resolver.caltech.edu/CaltechAUTHORS:20140421-105002893
https://resolver.caltech.edu/CaltechAUTHORS:20140421-105002893