Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Frederick Cohen"'
Autor:
Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, Rami N Hannoush, Christine D Pozniak, Frederick Cohen, Xianrui Zhao, Emile Plise, Joseph W Lewcock, Christopher E Heise
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30376 (2012)
Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention. A greater understanding of the role of caspase-6 in disease has b
Externí odkaz:
https://doaj.org/article/de49ec19875a41d9aa52b7a1c4028046
Autor:
Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50864 (2012)
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase
Externí odkaz:
https://doaj.org/article/86e58beea90d4df59b4e81e29a6f24b6
Autor:
Marilena Gallotta, Jennifa Gosling, Austin Tenn-McClellan, Serena Ranucci, Jose Gomez Romo, Frederick Cohen, Gwenn Hansen, Arthur Sands, Cristiana Guiducci, Ryan Rountree
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Marilena Gallotta, Jose Gomez Romo, Serena Ranucci, Austin Tenn-McClellan, Frederick Cohen, Gwenn Hansen, Arthur Sands, Ryan Rountree, Cristiana Guiducci
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Afroza Akhtar, Xueji Zhang, Sacco, Sophie E. Darch, Yu Chen, Kyle G. Kroeck, Logan D. Andrews, John E. Knox, D. Shoun, Frederick Cohen, Emmanuel W. Smith
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
The lipid A biosynthesis pathway is essential in Pseudomonas aeruginosa. LpxA and LpxD are the first and third enzymes in this pathway respectively, and are regarded as promising antibiotic targets. The unique structural similarities between these tw
Autor:
Frederick Cohen, James B. Aggen, Logan D. Andrews, Zahra Assar, Jen Boggs, Taylor Choi, Paola Dozzo, Ashton N. Easterday, Cat M. Haglund, Darin J. Hildebrandt, Melissa C. Holt, Kristin Joly, Adrian Jubb, Zeeshan Kamal, Timothy R. Kane, Andrei W. Konradi, Kevin M. Krause, Martin S. Linsell, Timothy D. Machajewski, Olga Miroshnikova, Heinz E. Moser, Vincent Nieto, Thu Phan, Craig Plato, Alisa W. Serio, Julie Seroogy, Anton Shakhmin, Adam J. Stein, Alex D. Sun, Serguei Sviridov, Zhan Wang, Kenneth Wlasichuk, Wen Yang, Xiaoming Zhou, Hai Zhu, Ryan T. Cirz
Publikováno v:
ChemMedChem. 14:1560-1572
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a Zn
Autor:
Lee Swem, Alisa W Serio, Chris M. Pillar, Amanda Burek, Danielle Hall, Frederick Cohen, Ryan Cirz, Kevin M. Krause, Eliana Saxon Armstrong, Christy M. Hebner, Adrian Jubb, Lynn Miesel, Grace Lee, Vincent Nieto, Mary Thwaites, Darrin Hildebrandt, Cat M. Haglund, Machajewski Timothy D, Timothy R. Kane, Meredith Hackel, Logan D. Andrews
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of
Autor:
Frederick Cohen, Jennifa Gosling, Monisha Mani, Austin Tenn-McClellan, Janine Powers, Whelan Sarah Anne, Arthur T. Sands, Gwenn M. Hansen, Michael T. Lotze
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A107-A107
BackgroundAdoptive cell transfer (ACT) of TIL effects durable responses in patients with melanoma and some epithelial tumors. It is thought that poor in vitro cell expansion and inefficient T-cell migration to the tumor limits the broader application
Autor:
William F. Forrest, Sumit Prakash, Vickie Tsui, Adam R. Renslo, Richard Pastor, Christiaan Klijn, Frank Peale, Mark McCleland, Lorna Kategaya, Carsten Schwerdtfeger, Zachary Stiffler, Matthias Trost, Frederick Cohen, Priyadarshini Jaishankar, Kevin R Clark, Paola Di Lello, Bradley B. Brasher, Florian Gnad, Michael C. M. Kwok, Johanna Heideker, Jeremy Murray, Jason Drummond, Xiaojing Wang, Maria Stella Ritorto, Till Maurer, Maureen Beresini, Matthew T. Chang, James A. Ernst, Taylur P. Ma, Robert A. Blake, Elizabeth Blackwood, Dario R. Alessi, Michelle R. Arkin, Lionel Rouge, Kebing Yu, Brian R. Hearn, Travis W. Bainbridge, Eva Lin, Tracy Kleinheinz, Yinyan Tang, Chudi Ndubaku, Scott E. Martin, John-Paul Upton, Ingrid E. Wertz
Publikováno v:
Nature. 550:534-538
The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7. Deubiquitinating
Autor:
Arthur T. Sands, Alexandra Borodovsky, Chris Karim, Austin Tenn-McClellan, Jose Gomez Romo, Gwenn M. Hansen, Jennifa Gosling, Jennifer Stokes, Ryan Rountree, Cristiana Guiducci, Marilena Gallotta, Frederick Cohen
Publikováno v:
Cancer Research. 81:1595-1595
The E3 ubiquitin ligase Casitas B-lineage lymphoma b (CBL-B) is expressed in T cells where it functions as an important negative regulator of immune activation. CBL-B d attenuates T-cell activation initiated by TCR engagement in part by mediating the