Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Frederick C. Kauffman"'
Autor:
Frederick C. Kauffman, Edna F. R. Pereira, Robert Schwarcz, Michelle C. Potter, Edson X. Albuquerque, Manickavasagom Alkondon
Publikováno v:
Journal of Neurophysiology. 97:1163-1170
Prepulse inhibition (PPI), a measure of sensorimotor gating impaired in patients with schizophrenia, is more sensitive to disruption by apomorphine in prepubertal August Copenhagen Irish (ACI) than Sprague-Dawley (SD) rats. In brain regions including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79922380d7a2be67c2adbbc2f9c9a44
https://doi.org/10.1152/jn.01119.2006
https://doi.org/10.1152/jn.01119.2006
Publikováno v:
Toxicology. 200:103-111
Excess production of H2O2 has been implicated in oncogenesis. The object of the present study was twofold: first, to determine the influence of chronic estradiol (E2) on the activities of selected hepatic antioxidant enzymes in female ACI rats, a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc4200f563ade631d1bfdbc94d795fd
https://doi.org/10.1016/j.tox.2004.03.009
https://doi.org/10.1016/j.tox.2004.03.009
Publikováno v:
Journal of Applied Toxicology. 19:411-419
The effects of sodium cyanide (NaCN) were investigated on the contractile and electrophysiological properties of rat diaphragm muscles in vitro. Sodium cyanide (0.1-1.0 mM) produced an initial potentiation of directly elicited twitch tensions, follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf336bb01a11cea26f3f06abd0c62141
https://doi.org/10.1002/(sici)1099-1263(199911/12)19:6<411::aid-jat597>3.0.co
https://doi.org/10.1002/(sici)1099-1263(199911/12)19:6<411::aid-jat597>3.0.co
Publikováno v:
Toxicology and Applied Pharmacology. 159:109-116
The aromatic retinoid, (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1 -propenyl] benzoic acid (TTNPB) is 1000-fold more teratogenic than all trans-retinoic acid (tRA) in several species. Factors that partially explain the potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a92f33d1294cab232bad3107302c8b
https://doi.org/10.1006/taap.1999.8726
https://doi.org/10.1006/taap.1999.8726
Autor:
Frederick C. Kauffman
Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds
Autor:
Gerald L. Princler, Marie C.M. Lin, Frederick C. Kauffman, Hsiang-Fu Kung, Jian Jian Li, Er Jia Wang
Publikováno v:
The FASEB Journal. 11:1145-1152
Microsomal triglyceride transfer protein (MTP) plays a central role in the assembly and secretion of apoB-containing lipoproteins. In this study, we investigated the effect of ethanol on the expression of the large subunit of MTP in a human liver hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaad60b91fe468b38382b2a29aad312e
https://doi.org/10.1096/fasebj.11.13.9367349
https://doi.org/10.1096/fasebj.11.13.9367349
Publikováno v:
Toxicology and Applied Pharmacology. 142:87-94
The toxicity of allyl alcohol was compared in freshly isolated and cryopreserved hepatocytes that were either placed in suspension or maintained on hydrated collagen gels in a sandwich configuration. The purpose of this study was to evaluate whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa06fe2d9b3710b97b7561a8e02762
https://doi.org/10.1006/taap.1996.8030
https://doi.org/10.1006/taap.1996.8030
Publikováno v:
Polycyclic Aromatic Compounds. 5:259-268
The so-called “reverse metabolism” technique for analysis of polycyclic aromatic hydrocarbon (PAH) metabolites through HI reduction to parent PAH fails for B[a]P. Most of the urinary metabolites of B[a]P are mercapturates. HCl hydrolysis of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5653ab4e3b9ab7dd8e6ccee0f9df3a09
https://doi.org/10.1080/10406639408015179
https://doi.org/10.1080/10406639408015179
Publikováno v:
Toxicology Letters. 74:79-90
This study shows that 1-hydroxybenzo[ a ]pyrene glucuronide and 1-hydroxybenzo[ a ]pyrene sulfate are formed in isolated rat hepatocytes. Formation of these conjugates by hepatocytes incubated with 1-acetoxy-[G- 3 H]benzo[ a ]pyrene (100 μM) as a so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cf467804dc494a0505b340fea65099
https://doi.org/10.1016/0378-4274(94)90076-0
https://doi.org/10.1016/0378-4274(94)90076-0
Publikováno v:
Developmental Pharmacology and Therapeutics. 18:81-88
Marked changes in rates of drug metabolism occur during adolescence; however, biochemical events underlying alterations in drug metabolism in whole hepatocytes during this period of development are not well established. Accordingly, metabolism of 7-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f4a622b48b6d454b790b6fd2a54bfe
https://doi.org/10.1159/000480601
https://doi.org/10.1159/000480601