Výsledky vyhledávání - "Frederick C W, Wu"

Akademický článek

The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort

Autor: Richard Ivell, Kee Heng, Katie Severn, Leen Antonio, Gyorgy Bartfai, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Aleksander Giwercman, Mario Maggi, Daryl B. O’Connor, Terence W. O’Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick C. W. Wu, Ravinder Anand-Ivell

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

BackgroundInsulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation statu

Externí odkaz: https://doaj.org/article/9827f7c591bb40f0b21cc1259e706eb3

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Akademický článek

Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

Autor: Nicholas J. W. Rattray, Drupad K. Trivedi, Yun Xu, Tarani Chandola, Caroline H. Johnson, Alan D. Marshall, Krisztina Mekli, Zahra Rattray, Gindo Tampubolon, Bram Vanhoutte, Iain R. White, Frederick C. W. Wu, Neil Pendleton, James Nazroo, Royston Goodacre

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Risk of age-related chronic disorders and decrease in resilience is associated with ageing. Here the authors analyse the human blood metabolome and identify metabolites associated with frailty.

Externí odkaz: https://doaj.org/article/f8a8be46f83b45fc975dd3c54a72ffd7

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Akademický článek

Androgens In Men Study (AIMS): protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men

Publikováno v: BMJ Open, Vol 10, Iss 5 (2020)

Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality

Externí odkaz: https://doaj.org/article/946e5b4343624bf48139c7ae6a59d260

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Serum testosterone and sex hormone–binding globulin are inversely associated with leucocyte telomere length in men: a cross-sectional analysis of the UK Biobank study

Autor: Ross J Marriott, Kevin Murray, Charley A Budgeon, Veryan Codd, Jennie Hui, Gillian M Arscott, John P Beilby, Graeme J Hankey, Gary A Wittert, Frederick C W Wu, Bu B Yeap

Publikováno v: European Journal of Endocrinology. 188

ObjectiveOlder men on an average have lower testosterone concentrations, compared with younger men, and more age-related comorbidities. Whether lower testosterone concentrations contribute to biological ageing remains unclear. Shorter telomeres are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50953abbf8dfc5b18a123146ad6c9021
https://doi.org/10.1093/ejendo/lvad015

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Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism

Autor: Finlay MacKenzie, Julian H Barth, Neil Smith, Frederick C. W. Wu, Sofia Llahana, Channa N. Jayasena, Richard A Anderson, Scott Wilkes, Sukhbinder Minhas, Prasanna Sooriakumaran, Jeremy W. Tomlinson, Richard Quinton

Publikováno v: Clinical Endocrinology. 96:200-219

Male hypogonadism (MH) is a common endocrine disorder. However, uncertainties and variations in its diagnosis and management exist. There are several current guidelines on testosterone replacement therapy that have been driven predominantly by single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d76cb4ed03288015cef228dac2a385
https://doi.org/10.1111/cen.14633

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Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40–79 years)

Autor: Ilpo Huhtaniemi, Frederick C. W. Wu, Lenore Dedeyne, Gyorgy Bartfai, Aleksander Giwercman, Jos Tournoy, Evelien Gielen, Terence W O'Neill, Giulia Rastrelli, Leen Antonio, Margus Punab, Felipe F. Casanueva, Jolanta Słowikowska-Hilczer, Mario Maggi, Jolan Dupont, Katrien Koppo, Dirk Vanderschueren

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1818-1831 (2021)
Dupont, J, Antonio, L, Dedeyne, L, O'Neill, T W, Vanderschueren, D, Rastrelli, G, Maggi, M, Bártfai, G, Casanueva, F F, Giwercman, A, Słowikowska-Hilczer, J, Punab, M, Huhtaniemi, I T, Wu, F C W, Tournoy, J, Koppo, K & Gielen, E 2021, ' Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years) ', Journal of cachexia, sarcopenia and muscle . https://doi.org/10.1002/jcsm.12785

BACKGROUND: Age-related chronic low-grade inflammation (inflammaging) is one of the proposed mechanisms behind sarcopenia. However, findings regarding inflammatory markers in sarcopenic older adults are conflicting. This study aimed to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3967eb6e70b6b717df2bf9ed042271e4
http://europepmc.org/articles/PMC8718046

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Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone–binding globulin in men from UK Biobank

Autor: Alvin M. Matsumoto, Frederick C. W. Wu, Bu B. Yeap, Claes Ohlsson, Leon Flicker, Shalender Bhasin, Christopher M. Reid, Leen Antonio, Kevin Murray, Adrian S. Dobs, Gary A. Wittert, Ross J. Marriott, Suchitra Raj, Girish Dwivedi, Eric S. Orwoll, Dirk Vanderschueren

Publikováno v: Clinical Endocrinology. 94:290-302

OBJECTIVE Serum testosterone concentrations are affected by factors unrelated to hypothalamo-pituitary-testicular axis pathology. We evaluated the impact of sociodemographic, lifestyle and medical factors, on serum testosterone and sex hormone-bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6ce96209710bd986a144275944c213
https://doi.org/10.1111/cen.14342

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Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men

Autor: Bu B Yeap, Ross J Marriott, Laurens Manning, Girish Dwivedi, Graeme J Hankey, Frederick C W Wu, Jeremy K Nicholson, Kevin Murray

Publikováno v: European journal of endocrinology. 187(1)

Objective Men are at greater risk from COVID-19 than women. Older, overweight men, and those with type 2 diabetes, have lower testosterone concentrations and poorer COVID-19-related outcomes. We analysed the associations of premorbid serum testostero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a94a14314270d5129e7a3e42f87cff8
https://pubmed.ncbi.nlm.nih.gov/35536887

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