Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Frederick C, Nucifora"'
Autor:
Hanna Jaaro-Peled, Melissa A. Landek-Salgado, Nicola G. Cascella, Frederick C. Nucifora, Jennifer M. Coughlin, Gerald Nestadt, Thomas W. Sedlak, Joelle Lavoie, Sarah De Silva, Somin Lee, Katsunori Tajinda, Hideki Hiyama, Koko Ishizuka, Kun Yang, Akira Sawa
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Under the hypothesis that olfactory neural epithelium gene expression profiles may be useful to look for disease-relevant neuronal signatures, we examined microarray gene expression in olfactory neuronal cells and underscored Notch–JAG pat
Externí odkaz:
https://doaj.org/article/46b911597477478da3dec7aec51fc3f1
Publikováno v:
BMC Psychiatry, Vol 21, Iss 1, Pp 1-4 (2021)
Abstract Background Neutropenia, a decrease in total number of neutrophils below 1500/mm3 and particularly severe neutropenia, defined as neutrophils less than 500/mm3, is a potential adverse effect of antipsychotic medications that can lead to incre
Externí odkaz:
https://doaj.org/article/2ca25869295149eba6e266ad51db494d
Publikováno v:
Neurobiology of Disease, Vol 131, Iss , Pp - (2019)
Treatment resistant schizophrenia (TRS) refers to the significant proportion of schizophrenia patients who continue to have symptoms and poor outcomes despite treatment. While many definitions of TRS include failure of two different antipsychotics as
Externí odkaz:
https://doaj.org/article/928e6e1de24e40429bd6cd16a6465b15
Autor:
Brian J. Lee, Robert O. Cotes, Ramin Mojtabai, Russell L. Margolis, Frederick C. Nucifora, Paul S. Nestadt
Publikováno v:
J Clin Psychiatry
OBJECTIVE: Clozapine is the most efficacious antipsychotic medication, but it is underutilized and its mechanism of action is still poorly understood. One aspect of its unique efficacy that requires further study is its effect on suicidality. A rando
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc579bb3af7664f7fe694ee73e8be781
https://europepmc.org/articles/PMC10069951/
https://europepmc.org/articles/PMC10069951/
Autor:
Frederick C. Nucifora, Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani, Simone Engelender, Dong Wei, Xiao-Fang Wang, Tianxia Li, Darren J. Moore, Olga Pletnikova, Juan C. Troncoso, Akira Sawa, Ted M. Dawson, Wanli Smith, Kah-Leong Lim, Christopher A. Ross
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages.
Externí odkaz:
https://doaj.org/article/0422154ec8e94aaeacb24bc6f49b8afd
Autor:
Min Wang, Peter B. Barker, Nicola G. Cascella, Jennifer M. Coughlin, Gerald Nestadt, Frederick C. Nucifora, Thomas W. Sedlak, Alexandra Kelly, Laurent Younes, Donald Geman, Lena Palaniyappan, Akira Sawa, Kun Yang
Publikováno v:
Molecular Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5fea147bc5567c884b590b506701b3d
https://doi.org/10.1038/s41380-023-01969-5
https://doi.org/10.1038/s41380-023-01969-5
Autor:
Alexandra Kelly, Jennifer M. Coughlin, Vidyulata Kamath, Anisha Nagpal, Zui Narita, Pasquale Di Carlo, Anshel Kenkare, Andreia V. Faria, Kun Yang, Nicola G. Cascella, Thomas W. Sedlak, Frederick C. Nucifora, Gerald Nestadt, Luisa Longo, Marina Mihaljevic, Peter B. Barker, Akira Sawa, Min Wang, Mehk Sethi
Publikováno v:
Molecular Psychiatry. 27:1184-1191
Treatment resistant (TR) psychosis is considered to be a significant cause of disability and functional impairment. Numerous efforts have been made to identify the clinical predictors of TR. However, the exploration of molecular and biological marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e9015763e18b8bea24b660bce681cd
https://doi.org/10.1038/s41380-021-01331-7
https://doi.org/10.1038/s41380-021-01331-7
Publikováno v:
Frontiers in Psychiatry, Vol 8 (2017)
Atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have utility in treating motor tics, particularly in Tourette syndrome. In rare cases, atypical antipsychotic medications have been associated with adult-onset mot
Externí odkaz:
https://doaj.org/article/81c196839853493c86bd3edc4eeeb3e6
Publikováno v:
Journal of Clinical Psychopharmacology. 41:180-185
Background Clozapine is the only medication with Food and Drug Administration approval for treatment-resistant schizophrenia. However, it is underutilized in the United States because of several life-threatening adverse effects, including clozapine-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d1769448286ce5eee488484b68d470
https://doi.org/10.1097/jcp.0000000000001358
https://doi.org/10.1097/jcp.0000000000001358
Autor:
Tianxia Li, Bingling Dai, Frederick C. Nucifora, Chun Feng Liu, Wanli W. Smith, Leslie G. Nucifora, Joseph M. Thomas, Xiaobo Wang, Gongbo Guo, Zhaohui Liu, Fengtian Xue, Christopher A. Ross
Publikováno v:
J Cell Physiol
Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a09c895302c14c3a3957bd536f8be
https://doi.org/10.1002/jcp.29632
https://doi.org/10.1002/jcp.29632