Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Frederick A. Valeriote"'
Autor:
J. Brian Morgan, Yang Liu, Veena Coothankandaswamy, Fakhri Mahdi, Mika B. Jekabsons, William H. Gerwick, Frederick A. Valeriote, Yu-Dong Zhou, Dale G. Nagle
Publikováno v:
Marine Drugs, Vol 13, Iss 3, Pp 1552-1568 (2015)
The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for
Externí odkaz:
https://doaj.org/article/81c9cdfe74804be6b9ba6bfe82baaec1
Autor:
Sheng Lin, Erin P. McCauley, Nicholas Lorig-Roach, Karen Tenney, Cassandra N. Naphen, Ai-Mei Yang, Tyler A. Johnson, Thalia Hernadez, Ramandeep Rattan, Frederick A. Valeriote, Phillip Crews
Publikováno v:
Marine Drugs, Vol 15, Iss 4, p 98 (2017)
This study began with the goal of identifying constituents from Zyzzya fuliginosa extracts that showed selectivity in our primary cytotoxicity screen against the PANC-1 tumor cell line. During the course of this project, which focused on six Z. fulig
Externí odkaz:
https://doaj.org/article/7f1d624e85c64bfcacc1322bd7873e20
Autor:
Tara Byrum, Lena Gerwick, Jehad Almaliti, William H. Gerwick, Frederick A. Valeriote, Tiago Leao, Ozlem Demirkiran, Gabriel Navarro
Publikováno v:
Journal of Natural Products. 84:2081-2093
Three new compounds, portobelamides A and B (1 and 2), 3-amino-2-methyl-7-octynoic acid (AMOYA) and hydroxyisovaleric acid (Hiva) containing cyclic depsipeptides, and one long chain lipopeptide caciqueamide (3), were isolated from a field-collection
Autor:
Christopher A. Rice, Scott D. Pegan, Joseph Media, Sandeep Dhanju, Kapil Upadhyaya, Frederick A. Valeriote, David Crich
Publikováno v:
Journal of the American Chemical Society. 142:9147-9151
We describe the synthesis of 10-aza-9-oxakalkitoxin, an N,N,O-trisubstituted hydroxylamine-based analog, or hydroxalog, of the cytotoxic marine natural product kalkitoxin in which the -NMe-O- moiety replaces a -CHMe-CH2- unit in the backbone of the n
Autor:
Tyler A. Johnson, David Coppage, Jiajiu Shaw, Phillip Crews, Joseph Media, Marcos A. Ogarrio, Frederick A. Valeriote, Erin P. McCauley, Joseph D. Morris, Lauren N Persi, Mani Maheshwari, Taylor C Garcia, Nicole L. McIntosh, Colon V. Cook
Publikováno v:
ACS Medicinal Chemistry Letters. 11:108-113
Reinvestigation of mycothiazole (1) revealed picomolar potency (IC50 = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α]D data indicating Vanuatu specimen
Autor:
Ozlem, Demirkiran, Jehad, Almaliti, Tiago, Leão, Gabriel, Navarro, Tara, Byrum, Frederick A, Valeriote, Lena, Gerwick, William H, Gerwick
Publikováno v:
Journal of natural products. 84(8)
Three new compounds, portobelamides A and B (
Autor:
Mark T. Hamann, Pankaj Pandey, Clemens Anklin, Yike Zou, Robert J. Doerksen, Bin Wang, Daneel Ferreira, Mitchell A. Avery, James Sims, Frederick A. Valeriote, Michelle Kelly, Colin L Welsh, Robert P. Stone, Xiaojuan Wang
Publikováno v:
Journal of the American Chemical Society. 141:4338-4344
We report here the orchestration of molecular ion networking and a set of computationally assisted structural elucidation approaches in the discovery of a new class of pyrroloiminoquinone alkaloids that possess selective bioactivity against pancreati
Autor:
Bailey W. Miller, C. Benjamin Naman, Jeffrey A. Hanson, Toni Kline, Frederick A. Valeriote, Halina Pietraszkiewicz, Jehad Almaliti, William H. Gerwick, Evgenia Glukhov, Xiaofan Li, Sihong Zhou
Publikováno v:
European Journal of Medicinal Chemistry. 161:416-432
Antibody-drug conjugates (ADCs) represent a new dimension of anticancer chemotherapeutics, with warheads to date generally involving either antitubulin or DNA-directed agents to achieve low-to sub-nanomolar potency. However, other potent cytotoxins w
Autor:
Sandeep, Dhanju, Kapil, Upadhyaya, Christopher A, Rice, Scott D, Pegan, Joseph, Media, Frederick A, Valeriote, David, Crich
Publikováno v:
Journal of the American Chemical Society. 142(20)
We describe the synthesis of 10-aza-9-oxakalkitoxin, an
Autor:
Frederick A. Valeriote, Yogan Khatri, Halina Pietraszkiewicz, David H. Sherman, Scott I Brody, Jennifer J. Schmidt, Catherine Zhu
Publikováno v:
ACS Chem Biol
The cryptophycins are a family of macrocyclic depsipeptide natural products that display exceptionally potent anti-proliferative activity against drug-resistant cancers. Unique challenges facing the synthesis and derivatization of this complex group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863135cc7bacf299bffe1be0fbafef35
https://europepmc.org/articles/PMC7094870/
https://europepmc.org/articles/PMC7094870/