Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Frederick A. Mann"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Understanding how genes function to heal wounds and restore lost tissue is essential for studying regeneration. Whole-mount in situ hybridization (WISH) is a powerful and widely used technique to visualize the expression patterns
Externí odkaz:
https://doaj.org/article/8bbec81549374ddcb7eaed0d6ce9ba30
Autor:
Christopher P. Arnold, Analí Migueles Lozano, Frederick G. Mann, Stephanie H. Nowotarski, Julianna O. Haug, Jeffrey J. Lange, Chris W. Seidel, Alejandro Sánchez Alvarado
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Hox genes are highly conserved and well-known for their role in segmental patterning during early development. Here, the authors identify an unreported role for Hox genes in the adult tissue patterning and fission behavior required for asexual reprod
Externí odkaz:
https://doaj.org/article/47e7a1a8e18d4eb2b1c276c8243bea15
Autor:
Stephanie H. Nowotarski, Christopher P. Arnold, Chris Seidel, Jeffrey J. Lange, Analí Migueles Lozano, Alejandro Sánchez Alvarado, Frederick G. Mann, Julianna O. Haug
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Hox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of the embryonic anterior-posterior (A/P) axis. We report functions for Hox genes in A/P tissue segmentation and transverse fission behavior und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03e7454c3f5234ce733cc5f84a9b28e
https://doaj.org/article/47e7a1a8e18d4eb2b1c276c8243bea15
https://doaj.org/article/47e7a1a8e18d4eb2b1c276c8243bea15
SummarySuccessful regeneration of missing tissues requires seamless integration of positional information along the body axes. Planarians, which regenerate from almost any injury, use conserved, developmentally important signaling pathways to pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba0b02f3bdfdfcfb3499170a77e71fe9
https://doi.org/10.1101/2022.07.14.500084
https://doi.org/10.1101/2022.07.14.500084
Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005956 (2016)
To understand the molecular processes underlying aging, we screened modENCODE ChIP-seq data to identify transcription factors that bind to age-regulated genes in C. elegans. The most significant hit was the GATA transcription factor encoded by elt-2,
Externí odkaz:
https://doaj.org/article/96798d3d795840328d6a650b02344878
Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration
Autor:
Blair W. Benham-Pyle, Frederick G. Mann, Carolyn E. Brewster, Enya R. Dewars, Dung M. Vuu, Stephanie H. Nowotarski, Carlos Guerrero-Hernández, Seth Malloy, Kate E. Hall, Lucinda E. Maddera, Shiyuan Chen, Jason A. Morrison, Sean A. McKinney, Brian D. Slaughter, Anoja Perera, Alejandro Sánchez Alvarado
SUMMARYStem cells enable regeneration by self-renewing and differentiating as instructed by a local microenvironment called a niche1–3. In most cases, the repair or replacement of tissues is fueled by tissue-specific or lineage-restricted stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6fe71249aa08d7bdc970f0808b7b7b5
https://doi.org/10.1101/2022.03.20.485025
https://doi.org/10.1101/2022.03.20.485025
Whole-mount in situ hybridization (WISH) is a powerful and widely used technique to visualize the expression pattern of genes in different biological systems. Here we describe a new protocol for ISH and immunostaining in the planarian Schmidtea medit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2f7c5ae7daf3f3d66abd19a9f1eb78
https://doi.org/10.1101/2021.11.01.466817
https://doi.org/10.1101/2021.11.01.466817
Autor:
Viraj Doddihal, Carlos Guerrero-Hernández, Laurence Florens, Alejandro Sánchez Alvarado, Michaella J. Levy, Ekasit Sonpho, Frederick G. Mann, Eric D. Ross, Puey Ounjai, Anita Saraf
Publikováno v:
Molecular & Cellular Proteomics : MCP
The extracellular matrix (ECM) is a three-dimensional network of macromolecules that provides a microenvironment capable of supporting and regulating cell functions. However, only a few research organisms are available for the systematic dissection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb97b36d5a16de5adc932446416d0e7f
http://europepmc.org/articles/PMC8503668
http://europepmc.org/articles/PMC8503668
Autor:
Jeffrey J. Lange, Christopher P. Arnold, Chris Seidel, A. Sanchez Alvarado, A. Migueles-Lozano, Frederick G. Mann
SummaryHox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of the embryonic anterior-posterior (A/P) axis1. Emerging evidence for Hox gene expression and function in postnatally derived structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9772716052a0d57a8ffa5d334b6d0b5d
https://doi.org/10.1101/2021.01.24.427972
https://doi.org/10.1101/2021.01.24.427972
Autor:
Viraj Doddihal, Carlos Guerrero-Hernández, Puey Ounjai, Ekasit Sonpho, Alejandro Sánchez Alvarado, Eric D. Ross, Michaella J. Levy, Frederick G. Mann, Laurence Florens, Anita Saraf
The extracellular matrix (ECM) is a three-dimensional network of macromolecules that provides a microenvironment capable of supporting and regulating cell functions. However, only a few research organisms are available for the systematic dissection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ae1ba3487dc64beb9dd7beb78fa8ab
https://doi.org/10.1101/2020.09.11.293936
https://doi.org/10.1101/2020.09.11.293936