Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Frederick A. Dick"'
Autor:
Trevor G. Shepherd, Frederick A. Dick
Publikováno v:
Cell Division, Vol 17, Iss 1, Pp 1-11 (2022)
Abstract In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy. Dormancy was first described in breast cancer where disease can remain undetected for d
Externí odkaz:
https://doaj.org/article/c63c33b94dcf4743a7ad5ec8b4ab60d4
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background The use of RNA-sequencing (RNA-seq) in molecular biology research and clinical settings has increased significantly over the past decade. Despite its widespread adoption, there is a lack of simple and interactive tools to analyze
Externí odkaz:
https://doaj.org/article/7269a9b37d414747a82cdb5a24ab146e
Autor:
Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster, Eugene Wong
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain metastases and small
Externí odkaz:
https://doaj.org/article/fdb6e5473117484daf7628971ef8cbef
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010551 (2022)
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPy
Externí odkaz:
https://doaj.org/article/20d6ff3165f54718b5c7480b0f8a536c
SummaryIn mammalian cells expression of repetitive genomic sequences is repressed by heterochromatin, underscoring the potential threat of repeat expression to cellular homeostasis. However, the specific consequences of ectopic repeat expression rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::461b6bcc65ab6eb207a161a13b2df242
https://doi.org/10.1101/2023.05.08.539798
https://doi.org/10.1101/2023.05.08.539798
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0203577 (2019)
RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression from G1 to S-phase in response to growth factor stimulation. Despite this role, it is genetically dispensable for cell cycle exit in primary fibroblast
Externí odkaz:
https://doaj.org/article/43ee85ef5b7d4cba9f4e255f17daa515
Autor:
Frederick A. Dick, Gabriel E. DiMattia, Larissa Litovchick, Pirunthan Perampalam, Yudith Ramos-Valdes, James MacDonald
S1. Cumulative viability score of siRNA knockdowns. S2. Spheroid morphology of control and gene knock down cells. S3. Reattachment of control and gene knockdown spheroid cells after 72 hours. S4. Relative protein expression levels of Dyrk1A and Dyrk1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b857915fc051fee607f9e791f43323
https://doi.org/10.1158/1541-7786.22511245.v1
https://doi.org/10.1158/1541-7786.22511245.v1
Autor:
Frederick A. Dick, Grant W. Brown, Paul C. Boutros, Ian Welch, Vanessa Percy, Alison L. Martens, Matthew J. Cecchini, Jianxin Wang, Srikanth Talluri, Aren Marshall, David Gallo, Charles A. Ishak, Courtney H. Coschi
PDF fie 148K, Description of additional genotypes of cells analyzed for gammaH2AX distribution and detailed instability phenotypes of heterozygous cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226390837fe1927a4626327b86ffb2d9
https://doi.org/10.1158/2159-8290.22529607
https://doi.org/10.1158/2159-8290.22529607
Autor:
Frederick A. Dick, Grant W. Brown, Paul C. Boutros, Ian Welch, Vanessa Percy, Alison L. Martens, Matthew J. Cecchini, Jianxin Wang, Srikanth Talluri, Aren Marshall, David Gallo, Charles A. Ishak, Courtney H. Coschi
PDF file 3766K, Analysis of gammaH2AX distribution, chromosomal instability phenotypes in heterozygous cells, and verification of genotypes in human cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2807682369f3681775b9ae11441ffe16
https://doi.org/10.1158/2159-8290.22529601.v1
https://doi.org/10.1158/2159-8290.22529601.v1