Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Frederic Y. Bois"'
Autor:
Liam Curry, Sarah Alrubia, Frederic Y. Bois, Ruth Clayton, Eman El‐Khateeb, Trevor N. Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami‐Hodjegan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1429-1447 (2024)
Abstract The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in vitro d
Externí odkaz:
https://doaj.org/article/769597f4e2694f17b0ec0f0ede76ea59
Autor:
Frederic Y. Bois, Céline Brochot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionIn virtual bioequivalence (VBE) assessments, pharmacokinetic models informed with in vitro data and verified with small clinical trials’ data are used to simulate otherwise unfeasibly large trials. Simulated VBE trials are assessed in a
Externí odkaz:
https://doaj.org/article/ebd1ff65513f461e853c27a5b3332e34
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1284 (2024)
Background/Objectives: Plasma levels of 4β-hydroxycholesterol (4β-OHC), a CYP3A-specific metabolite of cholesterol, are elevated after administration of CYP3A inducers like rifampicin and carbamazepine. To simulate such plasma 4β-OHC increase, we
Externí odkaz:
https://doaj.org/article/196f7ff56933489ebead894d0428330a
Autor:
Janak R. Wedagedera, Anthonia Afuape, Siri Kalyan Chirumamilla, Hiroshi Momiji, Robert Leary, Mike Dunlavey, Richard Matthews, Khaled Abduljalil, Masoud Jamei, Frederic Y. Bois
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 755-765 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo extrapolation. However, such extrapolations can be uncertain and may benefit from inclusio
Externí odkaz:
https://doaj.org/article/b22a6cafc47a40658b0d29adf692a9fc
Autor:
Chunyan Han, Tiancheng Sun, Siri Kalyan Chirumamilla, Frederic Y. Bois, Mandy Xu, Amin Rostami-Hodjegan
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2237 (2023)
The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration–time profiles in the systemic circulation, as a surrogate to the site of action. However, similarity of profiles from two formulations in the
Externí odkaz:
https://doaj.org/article/f7821e2ed5894eadb52805257af7eb9e
Autor:
Hiba Khalidi, Anthonia Onasanwo, Barira Islam, Heeseung Jo, Ciarán Fisher, Rich Aidley, Iain Gardner, Frederic Y. Bois
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
SimRFlow is a high-throughput physiologically based pharmacokinetic (PBPK) modelling tool which uses Certara’s Simcyp® simulator. The workflow is comprised of three main modules: 1) a Data Collection module for automated curation of physicochemica
Externí odkaz:
https://doaj.org/article/05e627da92eb40dba6a8e07ee9f1ec40
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 420-427 (2021)
Abstract As model‐informed drug development becomes an integral part of modern approaches to the discovery of new therapeutic entities and showing their safety and effectiveness, modalities of incorporating the paradigm into widespread practice req
Externí odkaz:
https://doaj.org/article/66e53f992c3f4325b9fdd7b5a482137d
Autor:
Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/5fb5ce51373249bfb13ca22770f6b10e
Autor:
Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Toxicological responses to chemical insult are largely regulated by transcriptionally activated pathways that may be independent, correlated and partially or fully overlapping. Investigating the dynamics of the interactions between stress responsive
Externí odkaz:
https://doaj.org/article/c18d3b58a931460a896ffcf06e513c59
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Traditionally, the solution to reduce parameter dimensionality in a physiologically-based pharmacokinetic (PBPK) model is through expert judgment. However, this approach may lead to bias in parameter estimates and model predictions if important param
Externí odkaz:
https://doaj.org/article/451ce9eea4274785a73d21ade58fe6bb