Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Frederic Vigant"'
Autor:
Scott D. Speer, Zhi Li, Sofija Buta, Béatrice Payelle-Brogard, Li Qian, Frederic Vigant, Erminia Rubino, Thomas J. Gardner, Tim Wedeking, Mark Hermann, James Duehr, Ozden Sanal, Ilhan Tezcan, Nahal Mansouri, Payam Tabarsi, Davood Mansouri, Véronique Francois-Newton, Coralie F. Daussy, Marisela R. Rodriguez, Deborah J. Lenschow, Alexander N. Freiberg, Domenico Tortorella, Jacob Piehler, Benhur Lee, Adolfo García-Sastre, Sandra Pellegrini, Dusan Bogunovic
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infect
Externí odkaz:
https://doaj.org/article/26d5278e9a6e4fe9b0df50d459031fb1
Autor:
Shannon M. Beaty, Arnold Park, Sohui T. Won, Patrick Hong, Michael Lyons, Frederic Vigant, Alexander N. Freiberg, Benjamin R. tenOever, W. Paul Duprex, Benhur Lee
Publikováno v:
mSphere, Vol 2, Iss 2 (2017)
ABSTRACT The notoriously low efficiency of Paramyxoviridae reverse genetics systems has posed a limiting barrier to the study of viruses in this family. Previous approaches to reverse genetics have utilized a wide variety of techniques to overcome th
Externí odkaz:
https://doaj.org/article/9ed5da7edaf44f2b8d23894e3de833c7
Autor:
Arnold Park, Tatyana Yun, Frederic Vigant, Olivier Pernet, Sohui T Won, Brian E Dawes, Wojciech Bartkowski, Alexander N Freiberg, Benhur Lee
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005659 (2016)
The budding of Nipah virus, a deadly member of the Henipavirus genus within the Paramyxoviridae, has been thought to be independent of the host ESCRT pathway, which is critical for the budding of many enveloped viruses. This conclusion was based on t
Externí odkaz:
https://doaj.org/article/bfbaab4065724a789412a8a68380ffcd
Autor:
Arnold Park, Patrick Hong, Sohui T Won, Patricia A Thibault, Frederic Vigant, Kasopefoluwa Y Oguntuyo, Justin D Taft, Benhur Lee
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The advent of RNA-guided endonuclease (RGEN)-mediated gene editing, specifically via CRISPR/Cas9, has spurred intensive efforts to improve the efficiency of both RGEN delivery and targeted mutagenesis. The major viral vectors in use for delivery of C
Externí odkaz:
https://doaj.org/article/a47e9ef0babb4529a61546002c818f9a
Autor:
Tobias Cohen, Toni M. Schwarz, Frederic Vigant, Thomas J. Gardner, Rosmel E. Hernandez, Benhur Lee, Domenico Tortorella
Publikováno v:
Viruses, Vol 8, Iss 10, p 295 (2016)
Human cytomegalovirus is a ubiquitous β-herpesvirus that infects many different cell types through an initial binding to cell surface receptors followed by a fusion event at the cell membrane or endocytic vesicle. A recent high-throughput screen to
Externí odkaz:
https://doaj.org/article/6fff204f3207416aa33d2663ff2d2659
Autor:
Frederic Vigant, Jihye Lee, Axel Hollmann, Lukas B Tanner, Zeynep Akyol Ataman, Tatyana Yun, Guanghou Shui, Hector C Aguilar, Dong Zhang, David Meriwether, Gleyder Roman-Sosa, Lindsey R Robinson, Terry L Juelich, Hubert Buczkowski, Sunwen Chou, Miguel A R B Castanho, Mike C Wolf, Jennifer K Smith, Ashley Banyard, Margaret Kielian, Srinivasa Reddy, Markus R Wenk, Matthias Selke, Nuno C Santos, Alexander N Freiberg, Michael E Jung, Benhur Lee
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003297 (2013)
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50 ≤ 0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogeni
Externí odkaz:
https://doaj.org/article/5782a66da0c04ff5a689050288b55985
Autor:
Frederic Vigant, Ani Kundu, Dongming Zhang, Wei Zhang, Ewa Jaruga-Killeen, Michelle Andraza, Gregory Schreiber, Alissa Kerner, Junyi Zhang, John Henkelman, Renata Soares, Ramya Yarlagadda, Gregory I. Frost, Sid P. Kerkar
Publikováno v:
Cancer Research. 82:3294-3294
Introduction: Chimeric antigen receptor therapies (CAR-T) are highly effective against hematologic malignancies but require a lymphodepleting chemotherapy regimen and are faced with many challenges including manufacturing time, scalability, and cost
Autor:
Ani Kundu, Dongming Zhang, Frederic Vigant, Junyi Zhang, Greg Schreiber, Ewa Jaruga-Killeen, Alissa Kerner, Michelle Andraza, Wei Zhang, John Henkelman, Renata Soares, Gregory I. Frost, Sid P. Kerkar
Publikováno v:
Cancer Research. 82:560-560
Background: We have previously established the ability of CD3-directed lentiviral vectors encoding for CD19 or CD22 CARs to mediate robust anti-tumor immunity in humanized lymphoreplete mouse models. We now present additional mechanistic data for thi
Autor:
Gregory I. Frost, Qun He, Michelle Andraza, Wei Zhang, Anirban Kundu, Ewa Jaruga-Killeen, Frederic Vigant, Gregory Schreiber, Hongliang Zong, Alissa R. Kerner
Publikováno v:
Regular and young investigator award abstracts.
Background Adoptive cellular therapy with chimeric antigen receptor (CAR)-T cells has demonstrated remarkable clinical activity in a number of hematologic malignancies, but product chain of custody, individualized manufacturing, preparative chemother
Autor:
Qun He, Sid P. Kerkar, Hongliang Zong, Ewa Jaruga-Killeen, Michelle Andraza, Wei Zhang, Gregory Schreiber, Anirban Kundu, Gregory I. Frost, Dongming Zhang, Frederic Vigant, Alissa R. Kerner
Publikováno v:
Cancer Research. 81:1511-1511
Background: Adoptive cell therapies using Chimeric Antigen Receptors (CARs) show durable clinical benefit for patients with hematologic malignancies, however, challenges remain for enabling this personalized treatment to be delivered in a timely, cos