Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Frederic Mallein‐Gerin"'
Autor:
Anne-Laure Durand, Alexandre Dufour, Elisabeth Aubert-Foucher, Christine Oger-Desfeux, Marielle Pasdeloup, Sebastien Lustig, Elvire Servien, Gualter Vaz, Emeline Perrier-Groult, Frederic Mallein-Gerin, Jerome E. Lafont
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6322 (2020)
Osteoarthritis (OA) is a degenerative disease of the joints which is associated with an impaired production of the cartilage matrix by the chondrocytes. Here, we investigated the role of Lysine-Specific Demethylase-1 (LSD1), a chromatin remodeling en
Externí odkaz:
https://doaj.org/article/e8e8c4b21cbb466881f959eb5d96acd3
Autor:
Cathrine Nordgaard, Anna Constance Vind, Amy Stonadge, Rasmus Kjøbsted, Goda Snieckute, Pedro Antas, Melanie Blasius, Marie Sofie Reinert, Ana Martinez Del Val, Dorte Breinholdt Bekker‐Jensen, Peter Haahr, Yekaterina A Miroshnikova, Abdelghani Mazouzi, Sarah Falk, Emeline Perrier‐Groult, Christopher Tiedje, Xiang Li, Jens Rithamer Jakobsen, Nicolas Oldenburg Jørgensen, Jørgen FP Wojtaszewski, Frederic Mallein‐Gerin, Jesper Løvind Andersen, Cristian Pablo Pennisi, Christoffer Clemmensen, Moustapha Kassem, Abbas Jafari, Thijn Brummelkamp, Vivian SW Li, Sara A Wickström, Jesper Velgaard Olsen, Gonzalo Blanco, Simon Bekker‐Jensen
Publikováno v:
EMBO Journal
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. How
Autor:
Frederic Mallein-Gerin, Martine Cohen-Solal, Marielle Pasdeloup, Eric Haÿ, Hang-Korng Ea, S. Moustaghfir, R. Schuele, Jérôme E. Lafont
Publikováno v:
Revue du Rhumatisme. 88:A156
Autor:
A. Dufour, Marielle Pasdeloup, Christine Oger-Desfeux, Elisabeth Aubert-Foucher, Frederic Mallein-Gerin, Elvire Servien, Emeline Perrier-Groult, Jérôme E. Lafont, G. Vaz, Sébastien Lustig, A. Durand
Publikováno v:
Revue du Rhumatisme. 87:A208
Introduction L’arthrose est une pathologie degenerative des articulations qui est associee a une alteration de la production de la matrice du cartilage par les chondrocytes. Nous avons etudie le role de la Lysine-Specific Demethylase-1 (LSD1), une
Autor:
Magali Demoor, Thibaud Jacquel, Sandrine Jacquet, Fabrice Audigié, Thomas Branly, Philippe Galéra, Romain Contentin, Mélanie Desancé, Jean-Marie Denoix, Frederic Mallein-Gerin, Lélia Bertoni
Publikováno v:
International Journal of Molecular Sciences; Volume 19; Issue 2; Pages: 435
International Journal of Molecular Sciences, Vol 19, Iss 2, p 435 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2018, 19 (2), pp.435. ⟨10.3390/ijms19020435⟩
International Journal of Molecular Sciences, Vol 19, Iss 2, p 435 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2018, 19 (2), pp.435. ⟨10.3390/ijms19020435⟩
International audience; Articular cartilage is a tissue characterized by its poor intrinsic capacity for self-repair. This tissue is frequently altered upon trauma or in osteoarthritis (OA), a degenerative disease that is currently incurable. Similar
Autor:
Emeline Perrier-Groult, Shérine Moustaghfir, Marielle Pasdeloup, Jean-Daniel Malcor, Jérôme Lafont, Frédéric Mallein-Gerin
Publikováno v:
Matrix Biology Plus, Vol 18, Iss , Pp 100130- (2023)
Type II collagen is the major fibrillar collagen in cartilage. It is synthesized in the form of precursors (procollagens) containing N- and C-terminal propeptides. The two main isoforms of type II procollagen protein are type IIA and type IIB procoll
Externí odkaz:
https://doaj.org/article/42d7056f7cbe47ea9ef8e0682d56cdbc
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Epigenetics defines the modifications of the genome that do not involve a change in the nucleotide sequence of DNA. These modifications constitute a mechanism of gene regulation poorly explored in the context of cartilage physiology. They are now int
Externí odkaz:
https://doaj.org/article/f3da471a4f974190921ac2923e6604bf
Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK
Publikováno v:
Osteoarthritis and cartilage. 24(5)
Summary Objective Since the biological effect of cartilage mediators is generally studied in a non-physiologic environment of 21% O 2 , we investigated the effects of a chronic hypoxia on the capability of articular chondrocytes to respond to one ana
Autor:
Safa Moslemi, Frederic Mallein-Gerin, David Ollitrault, Emmanuelle Renard, Florence Legendre, Christos Chadjichristos, Laure Maneix, Nicolas Bigot, Magali Demoor, Magdalini Kypriotou, Karim Boumediene, Benoît Porée, Benoit de Crombrugghe, Philippe Galéra
Publikováno v:
Journal of Molecular Medicine
Journal of Molecular Medicine, 2012, 90 (6), pp.649-666. ⟨10.1007/s00109-011-0842-3⟩
Journal of Molecular Medicine, 2012, 90 (6), pp.649-666. ⟨10.1007/s00109-011-0842-3⟩
Type II collagen is a marker of articular cartilage encoded by the COL2A1 gene. The nature of the trans factors involved in the upregulation of this gene by insulin-like growth factor-I (IGF-I) remains unclear. We found that IGF-I increased type II c
Autor:
Bjorn R. Olsen, Frederic Mallein-Gerin
Publikováno v:
Proceedings of the National Academy of Sciences. 90:3289-3293
We have infected primary embryonic mouse limb chondrocytes with a retrovirus carrying simian virus 40 early regions and have obtained a monoclonal mouse chondrocyte line, MC615, that was able to grow on culture dishes for at least 7 months and 20 pas