Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frederic Knoflach"'
Autor:
Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionSocial behavioral changes are a hallmark of several neurodevelopmental and neuropsychiatric conditions, nevertheless the underlying neural substrates of such dysfunction remain poorly understood. Building evidence points to the prefrontal
Externí odkaz:
https://doaj.org/article/e37f651846634462bb07b6af09bb1c64
Autor:
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinic
Externí odkaz:
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying
Externí odkaz:
https://doaj.org/article/2b44f2781de8400fa51141e60c25aa5b
Autor:
Eva C. Thoma, Claudia Merkl, Tobias Heckel, Rachel Haab, Frederic Knoflach, Corinne Nowaczyk, Nicholas Flint, Ravi Jagasia, Sannah Jensen Zoffmann, Hoa Hue Truong, Pascal Petitjean, Sebastian Jessberger, Martin Graf, Roberto Iacone
Publikováno v:
Stem Cell Reports, Vol 3, Iss 4, Pp 539-547 (2014)
Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects. Her
Externí odkaz:
https://doaj.org/article/1054ea04b2084c33907b36fc606bc3c8
Autor:
Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy
Social behavioral changes are a hallmark of several neurodevelopmental and neuropsychiatric conditions, nevertheless the underlying neural substrates of such dysfunction remain poorly understood. Building evidence points to the prefrontal cortex (PFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5517d0992a4a1b80793242e33bfdd738
https://doi.org/10.1101/2022.11.08.515590
https://doi.org/10.1101/2022.11.08.515590
Autor:
Uwe Gunther, Bernhard Lüscher, Frederic Knoflach, Horst Bluethmann, Michelle Arigoni, Guadalupe Reyes, Yolande Lang, Florence Crestani, Jean-Marc Fritschy, Adriano Aguzzi, Jack A. Benson, Dietmar Benke, Hanns Möhler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(17)
Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors. In vivo, BZ sites are potential targets for endogenous ligands regulating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c317929394c22bb7239084c1d01398a9
https://pubmed.ncbi.nlm.nih.gov/7644489
https://pubmed.ncbi.nlm.nih.gov/7644489
Autor:
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frédéric Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 86-95 (2016)
Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes
Externí odkaz:
https://doaj.org/article/c453283d07954edc80795548e6cfa550
Publikováno v:
PeerJ, Vol 6, p e5543 (2018)
Dysfunction of the N-methyl-d-aspartate receptor (NMDAR) is thought to play a role in the pathophysiology of neurodevelopmental diseases like schizophrenia. To study the effects of NMDAR dysfunction on synaptic transmission and network oscillations,
Externí odkaz:
https://doaj.org/article/f2a503c6a3574737861f007372473108
Autor:
Desirée Loreth, Laurence Ozmen, Florent G. Revel, Frédéric Knoflach, Philine Wetzel, Michael Frotscher, Friedrich Metzger, Oliver Kretz
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 1, Pp 1-12 (2012)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by brain accumulation of amyloid-β peptide and neurofibrillary tangles, which are believed to initiate a pathological cascade that results in progressive impairment of cognitive
Externí odkaz:
https://doaj.org/article/4326d00f10c448618d2448f3727060a1
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 2, Pp 386-393 (2010)
Long-term potentiation (LTP) and neurogenesis in the dentate gyrus (DG) are correlated forms of hippocampal plasticity which share, under physiological conditions, common regulatory mechanisms. In Alzheimer's disease (AD), their alterations are poten
Externí odkaz:
https://doaj.org/article/66ea42ae04944e69b7e158b67e603708