Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Frederic J de Sauvage"'
Autor:
Ganapati V Hegde, Cecile de la Cruz, Jennifer M Giltnane, Lisa Crocker, Avinashnarayan Venkatanarayan, Gabriele Schaefer, Debra Dunlap, Joerg D Hoeck, Robert Piskol, Florian Gnad, Zora Modrusan, Frederic J de Sauvage, Christian W Siebel, Erica L Jackson
Publikováno v:
eLife, Vol 8 (2019)
Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this s
Externí odkaz:
https://doaj.org/article/6f4e75535ef4450d90e11913cada4356
Autor:
Kui Lin, James R Taylor, Thomas D Wu, Johnny Gutierrez, J Michael Elliott, Jean-Michel Vernes, Hartmut Koeppen, Heidi S Phillips, Frederic J de Sauvage, Y Gloria Meng
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18608 (2011)
BACKGROUND: TMEFF2 is a protein containing a single EGF-like domain and two follistatin-like modules. The biological function of TMEFF2 remains unclear with conflicting reports suggesting both a positive and a negative association between TMEFF2 expr
Externí odkaz:
https://doaj.org/article/9a9b90e946d248ae8924316815b18427
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Hadir Marei, Wen-Ting K. Tsai, Yee-Seir Kee, Karen Ruiz, Jieyan He, Chris Cox, Tao Sun, Sai Penikalapati, Pankaj Dwivedi, Meena Choi, David Kan, Pablo Saenz-Lopez, Kristel Dorighi, Pamela Zhang, Yvonne T. Kschonsak, Noelyn Kljavin, Dhara Amin, Ingrid Kim, Andrew G. Mancini, Thao Nguyen, Chunling Wang, Eric Janezic, Alexander Doan, Elaine Mai, Hongkang Xi, Chen Gu, Melanie Heinlein, Brian Biehs, Jia Wu, Isabelle Lehoux, Seth Harris, Laetitia Comps-Agrar, Dhaya Seshasayee, Frederic J. de Sauvage, Matthew Grimmer, Jing Li, Nicholas J. Agard, Felipe de Sousa e Melo
Publikováno v:
Nature. 610:182-189
Most current therapies that target plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. However, typical mammalian proteins comprise multiple domains that execute discrete but coordinated activities. Thus, inhibi
Autor:
Stephen E. Gould, Frederic J. de Sauvage, Robert L. Yauch, Tom Januario, Hank La, Patricia Pacheco, Kristina A. West, Bruno Alicke, Harvey Wong
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a94d3e334ec0722a175a9109310ce0
https://doi.org/10.1158/1078-0432.22442118
https://doi.org/10.1158/1078-0432.22442118
Autor:
Sergey I. Nikolaev, Nicole Basset-Seguin, Lukas Flatz, Nicolas Dumaz, Frederic J. de Sauvage, Jerome Lambert, Florian Herms, Philippe Saiag, Caroline Robert, Caroline Dutriaux, Nicolas Meyer, Laurent Mortier, Sandrine Monestier, Florent Grange, Max Mendez-Lopez, Andrej Besse, Ariel Savina, Fanny Bouquet, Samia Mourah, Maxime Battistella, Nadem Soufir, Antonio Alberti, Marc Delord, Amir Khammari, Brigitte Dreno, Nicolas Poulalhon, Hayley J. Sharpe, Fatemeh Rajabi, Ismael Padioleau, Meriem Ighilahriz, Oltin T. Pop, Andrey A. Yurchenko
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351f6102c14b7c4e17ca3b39ea656edf
https://doi.org/10.1158/1078-0432.22487462.v1
https://doi.org/10.1158/1078-0432.22487462.v1
Autor:
Sergey I. Nikolaev, Nicole Basset-Seguin, Lukas Flatz, Nicolas Dumaz, Frederic J. de Sauvage, Jerome Lambert, Florian Herms, Philippe Saiag, Caroline Robert, Caroline Dutriaux, Nicolas Meyer, Laurent Mortier, Sandrine Monestier, Florent Grange, Max Mendez-Lopez, Andrej Besse, Ariel Savina, Fanny Bouquet, Samia Mourah, Maxime Battistella, Nadem Soufir, Antonio Alberti, Marc Delord, Amir Khammari, Brigitte Dreno, Nicolas Poulalhon, Hayley J. Sharpe, Fatemeh Rajabi, Ismael Padioleau, Meriem Ighilahriz, Oltin T. Pop, Andrey A. Yurchenko
Purpose:Vismodegib is approved for the treatment of locally advanced basal cell carcinoma (laBCC), but some cases demonstrate intrinsic resistance (IR) to the drug. We sought to assess the frequency of IR to vismodegib in laBCC and its underlying gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2b97d45e46bb583500481210757562
https://doi.org/10.1158/1078-0432.c.6532523.v1
https://doi.org/10.1158/1078-0432.c.6532523.v1
Autor:
Frederic J. de Sauvage, Ivor Caro, Ervin H. Epstein, James C. Marsters, Lee L. Rubin, Angela Wu, Elana Shpall, Kris S. Chang, Karen Kotkow, Frank Wang, Robert L. Yauch, Ling Fu, Christopher A. Callahan, Mike Reich, Dongwei Li, Jean Y. Tang, Tracy Tang
Supplementary Materials and Methods; Supplementary Tables S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5843873f54a17988876092c3b15e71ba
https://doi.org/10.1158/1078-0432.22440850.v1
https://doi.org/10.1158/1078-0432.22440850.v1
Autor:
Stephen E. Gould, Frederic J. de Sauvage, Robert L. Yauch, Tom Januario, Hank La, Patricia Pacheco, Kristina A. West, Bruno Alicke, Harvey Wong
Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by mutational or ligand-dependent activation of the Hh pathway. We wished to characterize the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05d826ad700813b04b4e6eb577edae7
https://doi.org/10.1158/1078-0432.c.6518937
https://doi.org/10.1158/1078-0432.c.6518937
Autor:
Frederic J. de Sauvage, Ivor Caro, Ervin H. Epstein, James C. Marsters, Lee L. Rubin, Angela Wu, Elana Shpall, Kris S. Chang, Karen Kotkow, Frank Wang, Robert L. Yauch, Ling Fu, Christopher A. Callahan, Mike Reich, Dongwei Li, Jean Y. Tang, Tracy Tang
Purpose: Inappropriate activation of the Hedgehog (Hh) signaling pathway in skin is critical for the development of basal cell carcinomas (BCC). We have investigated the anti-BCC efficacy of topically-applied CUR61414, an inhibitor of the Hh signal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd72233859bb4f53ad71624a49cc6b3
https://doi.org/10.1158/1078-0432.c.6518113
https://doi.org/10.1158/1078-0432.c.6518113