Zobrazeno 1 - 10
of 6 184
pro vyhledávání: '"Frederic J"'
Publikováno v:
eLife, Vol 13 (2024)
Our understanding of mitochondrial signaling in the nervous system has been limited by the technical challenge of analyzing mitochondrial function in vivo. In the transparent genetic model Caenorhabditis elegans, we were able to manipulate and measur
Externí odkaz:
https://doaj.org/article/fc1339337c274e029099f2ab6ad42094
Autor:
Padmanee Sharma, Asim Amin, Dung T Le, Michael A Morse, Marina Tschaika, Matthew H Taylor, Margaret Callahan, Katriina J Peltola, Frederic J Kaye, Eileen M O'Reilly, Stephanie Meadows Shropshire, Shaun O'Brien
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Pancreatic cancer is one of the deadliest cancer types and represents a major unmet medical need. CheckMate 032 investigated safety and efficacy of nivolumab monotherapy and nivolumab plus ipilimumab with/without cobimetinib in advanced/me
Externí odkaz:
https://doaj.org/article/45a8cb7600f34aa197804f7caa0fc19c
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Camila Caram-Deelder, Hellen McKinnon Edwards, Jarmila A. Zdanowicz, Thomas van den Akker, Camilla Birkegård, Jan Blatný, Johanna G. van der Bom, Giuseppe Colucci, Derek van Duuren, Nan van Geloven, Dacia D. C. A. Henriquez, Marian Knight, Lars Korsholm, Andrea Landorph, Géraldine Lavigne Lissalde, Zoe K. McQuilten, Daniel Surbek, Cameron Wellard, Erica M. Wood, Frederic J. Mercier
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 9, p 2656 (2024)
Background: Despite a range of available treatments, it is still sometimes challenging to treat patients with severe post-partum hemorrhage (sPPH). Objective: This study evaluated the efficacy and safety of recombinant activated factor VIIa (rFVIIa)
Externí odkaz:
https://doaj.org/article/f2fd79a1064749498cbf2a06d9ac1688
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/49d95d507a8d48b09671436fb6e5c625
Autor:
Frederic J. Washburn DO, Conner S. Roggy DO, Britni Tran BS, Casey W. Pyle DO, Thomas G. Harris MD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 8 (2023)
Category: Trauma; Arthroscopy Introduction/Purpose: Deltoid ligament rupture is a common occurrence in the setting of acute ankle fractures. The indications for surgical restoration of the deltoid ligament complex vary considerably throughout the lit
Externí odkaz:
https://doaj.org/article/ee8655a8c7ff405eb2d63a04f9b27ad6
Autor:
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Publikováno v:
Cells, Vol 13, Iss 6, p 528 (2024)
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in p
Externí odkaz:
https://doaj.org/article/a29e79df61604c65a48287af106a045c
Autor:
Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye, Daohong Zhou
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, including BCL-XL and MCL-1. Unfortun
Externí odkaz:
https://doaj.org/article/35172677c9ab498385ddea2d7bbcff21
Autor:
Jorge Parra, Arthie Jeyakumar, Jeffrey Forris Beecham Chick, Caitlin A. Smith, Frederic J. Bertino, Eric J. Monroe
Publikováno v:
Journal of Clinical Interventional Radiology ISVIR, Vol 06, Iss 03, Pp 207-211 (2022)
Techniques for gastrostomy revision to gastrojejunostomy within the pediatric population, who have failed initial tube placement due to obstructive pathologies, have not been well established. Novel techniques are required to improve outcomes for the
Externí odkaz:
https://doaj.org/article/4aa9a4b1463c4f318e6b65e82c3af1b8
Autor:
Janina Rzeznitzeck, Gerhard Breves, Ivan Rychlik, Frederic J. Hoerr, Alexandra von Altrock, Alexandra Rath, Silke Rautenschlein
Publikováno v:
Gut Pathogens, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Campylobacter (C.) species are the most common bacterial cause of foodborne diarrhea in humans. Despite colonization, most animals do not show clinical signs, making recognition of affected flocks and disruption of the infection c
Externí odkaz:
https://doaj.org/article/5476e045c48d4c5a93838b8bef877444