Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Frederic Gachon"'
Autor:
Ludmila Gaspar, Cedric Howald, Konstantin Popadin, Bert Maier, Daniel Mauvoisin, Ermanno Moriggi, Maria Gutierrez-Arcelus, Emilie Falconnet, Christelle Borel, Dieter Kunz, Achim Kramer, Frederic Gachon, Emmanouil T Dermitzakis, Stylianos E Antonarakis, Steven A Brown
Publikováno v:
eLife, Vol 6 (2017)
The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic
Externí odkaz:
https://doaj.org/article/07095c76ca49459584a75d993cfa78bf
Autor:
Irene Miguel-Aliaga, Gordana Vunjak-Novakovic, Erin J. Stephenson, Frederic Gachon, Inês Milagre, Evanna Mills, Joshua B. Rubin, Iva Kelava
Publikováno v:
Developmental cell. 57(24)
Researchers are exploring sex differences in experimental models of both development and disease—but are we doing enough? In this collection of Voices, we celebrate researchers who are asking this question and starting to offer mechanistic clues on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838b9ddbd8c4f09e1fe952b6e63b8558
https://pubmed.ncbi.nlm.nih.gov/36538892
https://pubmed.ncbi.nlm.nih.gov/36538892
Autor:
Sachini Fonseka, Benjamin D. Weger, Meltem Weger, Nick Martel, Thomas E. Hall, Shayli Varasteh Moradi, Christian H. Gabriel, Achim Kramer, Charles Ferguson, Manuel A. Fernández-Rojo, Kirill Alexandrov, Oliver Rawashdeh, Kerrie-Ann McMahon, Frederic Gachon, Robert G Parton
Caveolae are specialized invaginations of the plasma membrane that are formed by the co-assembly of caveolin integral membrane proteins and a cytoplasmic cavin coat complex. Previous work has proposed an interaction of the cavin coat protein, CAVIN3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3536061fcaaa34d293da444415f349
https://doi.org/10.1101/2022.10.10.511681
https://doi.org/10.1101/2022.10.10.511681
Autor:
Oystein Tronstad, Barbara Zangerl, Sue Patterson, Dylan Flaws, Stephanie Yerkovich, Irene Szollosi, Nicole White, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Benjamin D. Weger, Frédéric Gachon, David Brain, Jayshree Lavana, Carol Hodgson, John F. Fraser
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Intensive care medicine continues to improve, with advances in technology and care provision leading to improved patient survival. However, this has not been matched by similar advances in ICU bedspace design. Environmental factor
Externí odkaz:
https://doaj.org/article/11bde79417264abd8f118de85c0a79d2
Autor:
Lu Ding, Benjamin D. Weger, Jieying Liu, Liyuan Zhou, Yenkai Lim, Dongmei Wang, Ziyan Xie, Jing Liu, Jing Ren, Jia Zheng, Qian Zhang, Miao Yu, Meltem Weger, Mark Morrison, Xinhua Xiao, Frédéric Gachon
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110343- (2024)
Summary: Maternal obesity has long-term effects on offspring metabolic health. Among the potential mechanisms, prior research has indicated potential disruptions in circadian rhythms and gut microbiota in the offspring. To challenge this hypothesis,
Externí odkaz:
https://doaj.org/article/8e36d260e1e04b198d40783de715f116
Autor:
Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D. Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Götz, Mark Ibberson, Sylvain Pradervand, Manfredo Quadroni, Meltem Weger, Francesca Amati, Frédéric Gachon, Dmitri Firsov
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcriptomic, proteo
Externí odkaz:
https://doaj.org/article/9d19b4af4f6f47d69c7af02c26f827e1
Publikováno v:
Cellular Physiology and Biochemistry, Vol 56, Iss S2, Pp 1-11 (2022)
Externí odkaz:
https://doaj.org/article/a2ccd188b9f844ea975cd79b1dddbb7f
Autor:
Meltem Weger, Benjamin D Weger, Andrea Schink, Masanari Takamiya, Johannes Stegmaier, Cédric Gobet, Alice Parisi, Andrei Yu Kobitski, Jonas Mertes, Nils Krone, Uwe Strähle, Gerd Ulrich Nienhaus, Ralf Mikut, Frédéric Gachon, Philipp Gut, Thomas Dickmeis
Publikováno v:
eLife, Vol 9 (2020)
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown o
Externí odkaz:
https://doaj.org/article/3ce0c8c614c1482a8e39f6ec82430ce8
Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability
Autor:
Zhifeng Huang, Florian Atger, Loïc Dayon, Antonio Núñez Galindo, Jingkui Wang, Eva Martin, Laetitia Da Silva, Ivan Montoliu, Sebastiano Collino, Francois-Pierre Martin, Joanna Ratajczak, Carles Cantó, Martin Kussmann, Felix Naef, Frédéric Gachon
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1717-1728 (2017)
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modificatio
Externí odkaz:
https://doaj.org/article/3aa9c1bfec0b4f3d81065c8e401a3545
Autor:
Laurent Perrin, Ursula Loizides-Mangold, Stéphanie Chanon, Cédric Gobet, Nicolas Hulo, Laura Isenegger, Benjamin D Weger, Eugenia Migliavacca, Aline Charpagne, James A Betts, Jean-Philippe Walhin, Iain Templeman, Keith Stokes, Dylan Thompson, Kostas Tsintzas, Maud Robert, Cedric Howald, Howard Riezman, Jerome N Feige, Leonidas G Karagounis, Jonathan D Johnston, Emmanouil T Dermitzakis, Frédéric Gachon, Etienne Lefai, Charna Dibner
Publikováno v:
eLife, Vol 7 (2018)
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchro
Externí odkaz:
https://doaj.org/article/8ea7e67b24d542c897c0de2adf446cbc