Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Frederic Feru"'
Autor:
Thomas W. Gero, David E. Heppner, Tyler S. Beyett, Ciric To, Seth C. Azevedo, Jaebong Jang, Thomas Bunnell, Frederic Feru, Zhengnian Li, Bo Hee Shin, Kara M. Soroko, Prafulla C. Gokhale, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck, David A. Scott
Publikováno v:
Bioorganicmedicinal chemistry letters. 68
The C797S mutation confers resistance to covalent EGFR inhibitors used in the treatment of lung tumors with the activating L858R mutation. Isoindolinones such as JBJ-4-125-02 bind in an allosteric pocket and are active against this mutation, with hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bfb1415ffe44876f18b0e35b149a21
https://pubmed.ncbi.nlm.nih.gov/35378251
https://pubmed.ncbi.nlm.nih.gov/35378251
Autor:
Theresa L. Johnson, Steven Kazmirski, Simon Low, Cyrille Kuhn, Robert V. Stanton, Yuan-Hua Ding, Gayatri D. Deshmukh, Jessie M. English, Haile Tecle, Glen Rennie, Ping Ye, Hu Liu, Joseph Wu, Alan C. Cheng, Suzanne L. Jacques, Rocco Coli, Frederic Feru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4885-4891
By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cbf5efbbf3041f28125e01eba59d8c
https://doi.org/10.1016/j.bmcl.2010.06.073
https://doi.org/10.1016/j.bmcl.2010.06.073
Autor:
Darcy Kohls, Simon Low, Glen Rennie, Yuan-Hua Ding, Cyrille Kuhn, Frederic Feru, Michael Kothe, Rocco Coli
Publikováno v:
Chemical Biology & Drug Design. 70:540-546
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f56f22404ef9e96e6c481d195548de
https://doi.org/10.1111/j.1747-0285.2007.00594.x
https://doi.org/10.1111/j.1747-0285.2007.00594.x
Autor:
Michael, Kothe, Darcy, Kohls, Simon, Low, Rocco, Coli, Glen R, Rennie, Frederic, Feru, Cyrille, Kuhn, Yuan-Hua, Ding
Publikováno v:
Chemical biologydrug design. 70(6)
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b5ead468ecaa06166846290429bfcb1
https://pubmed.ncbi.nlm.nih.gov/18005335
https://pubmed.ncbi.nlm.nih.gov/18005335
Autor:
Eric Auclair, Veronique Fasquelle, Annette M. Doherty, Kam Chan, Stéphane Milano, Emmanuelle Lallier, Bernadette Bertin, Malika Ouagued, Marie-Noelle Rocher, Catherine Burnouf, Christèle Bigot, Brigitte Martin, Roger Wrigglesworth, Marie-Pierre Pruniaux, Richard B. Gilbertsen, Frederic Feru, Jocelyne Puaud, Nadine Avenel, Jacquie Maignel, Yves Pascal, Adel Kebsi, Calvet Alain Pierre, Henry Jacobelli, Christophe Terrasse, Corinne Durand
Publikováno v:
Journal of medicinal chemistry. 43(25)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e0a99010577cf538d277f8e060d10e
https://pubmed.ncbi.nlm.nih.gov/11123995
https://pubmed.ncbi.nlm.nih.gov/11123995