Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients

Autor: Rosemary J. Akhurst, Boris C. Bastian, Ervin H. Epstein, Dan H. Moore, Jesus Perez-Losada, Frederic F. Clermont, Elise F. Saunier, Katie Ridd, Kelly A. Harradine

Purpose: Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth factor-β1 (TGF-β1) levels, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d1305de02cb2d765327d16e3d66c22
https://doi.org/10.1158/1078-0432.c.6517639.v1

Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans

Autor: Tom G. W. Letteboer, Ritu Roy, Michael Benzinou, Gaeten Lesca, Dominique S. Meyer, Sophie Dupuis-Girod, Akiko Tochimoto-Okamoto, Frederic F. Clermont, Gloria Wu, Kyoko Kawasaki, Rosemary J. Akhurst, Robert J. Coffey, Johannes Kristian Ploos Van Amstel, Marie Mei Lee, S. Giraud, C.J.J. Westermann, Julia Freimuth

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 21
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcome of TGFβ1 signaling is context dependent and differs between individuals due to germ-line genetic variation. To explore innate genetic variants that determine differential outcome of reduced TGFβ1 signaling, we dissected the modifier locus T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce980d6a9d48217c47c75034501ced81
https://pubmed.ncbi.nlm.nih.gov/24812125

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia

Autor: Silvia Espejel, Michael Benzinou, Sophie Dupuis-Girod, Tom G. W. Letteboer, Bradley E. Aouizerat, Musa Zaid, David A. Quigley, Sophie Giraud, C.J.J. Westermann, Rosemary J. Akhurst, Johannes Kristian Ploos Van Amstel, Jai-Hyun Kim, Juan Arbelaez, Frederic F. Clermont, Gaetan Lesca, Henri Plauchu, Christopher C.W. Hughes, Mamie Nakayama Higgins, Minh Thu Luu, Ritu Roy, Kelly A. Harradine

Publikováno v: Nature Communications. 3

Hereditary haemorrhagic telangiectasia (HHT) [corrected] is a vascular dysplasia syndrome caused by mutations in transforming growth factor-β/bone morphogenetic protein pathway genes, ENG and ACVRL1. HHT [corrected] shows considerable variation in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28eff322369641107410c74860a272c
https://doi.org/10.1038/ncomms1633

Characterization of Tgfbm2 , a genetic modifier of Tgfb1 −/− embryonic lethality

Autor: Mamie Nakayama Higgins, Rosemary J. Akhurst, Frederic F. Clermont, Minh Thu Luu

Publikováno v: The FASEB Journal. 21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86f43a02670e22d8b2e7e363b432d75
https://doi.org/10.1096/fasebj.21.6.lb73-b

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.

Autor: Nittner D; Laboratory for Molecular Cancer Biology, Center for the Biology of Disease, VIB, 3000 Leuven, Belgium., Lambertz I, Clermont F, Mestdagh P, Köhler C, Nielsen SJ, Jochemsen A, Speleman F, Vandesompele J, Dyer MA, Schramm A, Schulte JH, Marine JC

Publikováno v: Nature cell biology [Nat Cell Biol] 2012 Sep; Vol. 14 (9), pp. 958-65. Date of Electronic Publication: 2012 Aug 05.